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Review

Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage

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Pages 1695-1708 | Received 30 Mar 2016, Accepted 07 Jun 2016, Published online: 24 Jun 2016

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Mariano Bizzarri, Patrizia Logoteta, Giovanni Monastra & Antonio Simone Laganà. (2022) An innovative approach to polycystic ovary syndrome. Journal of Obstetrics and Gynaecology 42:4, pages 546-556.
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Hadise Aslfalah, Mehri Jamilian & Ali Khosrowbeygi. (2019) Elevation of the adiponectin/leptin ratio in women with gestational diabetes mellitus after supplementation with alpha-lipoic acid. Gynecological Endocrinology 35:3, pages 271-275.
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Babatunde Fasipe, Andre Faria & Ismail Laher. (2023) Potential for Novel Therapeutic Uses of Alpha Lipoic Acid. Current Medicinal Chemistry 30:35, pages 3942-3954.
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Xi-Zi Zhu, Zhi-Min Deng, Fang-Fang Dai, Hua Liu & Yan-Xiang Cheng. (2023) The impact of early pregnancy metabolic disorders on pregnancy outcome and the specific mechanism. European Journal of Medical Research 28:1.
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M. Di Lorenzo, N. Cacciapuoti, M. S. Lonardo, G. Nasti, C. Gautiero, A. Belfiore, B. Guida & M. Chiurazzi. (2023) Pathophysiology and Nutritional Approaches in Polycystic Ovary Syndrome (PCOS): A Comprehensive Review. Current Nutrition Reports.
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Ramanachary Namoju & Naga Kavitha Chilaka. (2022) Maternal supplementation of α-lipoic acid attenuates prenatal cytarabine exposure-induced oxidative stress, steroidogenesis suppression and testicular damage in F1 male rat fetus. Beni-Suef University Journal of Basic and Applied Sciences 11:1.
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Megan Pagan, Joshua Monson, Ryan Strebeck, Sarah Edwards & Everett F. Magann. (2022) Subchorionic Hemorrhage in the Second and Third Trimesters of Pregnancy: A Review. Obstetrical & Gynecological Survey 77:12, pages 745-752.
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Demet Aydogan Kirmizi, Emre Baser, Aslı Okan & Zuleyha Doganyigit. (2022) Receptivity, autophagy, and implantation in endometriosis; does antioxidant work? An experimental study. Journal of Food Biochemistry 46:10.
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Cristina Esposito, Emanuele Ugo Garzarella, Cristina Santarcangelo, Alessandro Di Minno, Marco Dacrema, Roberto Sacchi, Gaetano Piccinocchi, Roberto Piccinocchi & Maria Daglia. (2021) Safety and efficacy of alpha-lipoic acid oral supplementation in the reduction of pain with unknown etiology: A monocentric, randomized, double-blind, placebo-controlled clinical trial. Biomedicine & Pharmacotherapy 144, pages 112308.
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Eun Hui Joo, Young Ran Kim, Nari Kim, Jae Eun Jung, Seon Ha Han & Hee Young Cho. (2021) Effect of Endogenic and Exogenic Oxidative Stress Triggers on Adverse Pregnancy Outcomes: Preeclampsia, Fetal Growth Restriction, Gestational Diabetes Mellitus and Preterm Birth. International Journal of Molecular Sciences 22:18, pages 10122.
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Neha Sharma, Oliver C. Watkins, Anne H.Y. Chu, W. Cutfield, Keith M. Godfrey, Hannah E. J. Yong & Shiao-Yng Chan. (2021) Myo -inositol: a potential prophylaxis against premature onset of labour and preterm birth . Nutrition Research Reviews, pages 1-9.
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Aida Petca, Mihaela Bot, Nicoleta Maru, Ioana Calo, Andreea Borislavschi, Mihai Dumitrascu, Razvan-Cosmin Petca, Florica Sandru & Mona Zvanca. (2021) Benefits of α‑lipoic acid in high‑risk pregnancies (Review). Experimental and Therapeutic Medicine 22:5.
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Ramanachary Namoju & Naga Kavitha Chilaka. (2020) Alpha-lipoic acid ameliorates cytarabine-induced developmental anomalies in rat fetus. Human & Experimental Toxicology 40:5, pages 851-868.
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Tingxu Yan, Bing Liu, Nizhi Wang, Zhengzheng Liao, Bo Wu, Bosai He & Ying Jia. (2021) The flavonoids of okra insulates against oxidative stress, neuroinflammation and restores BDNF levels in Aβ1–42 induced mouse model of Alzheimer's disease. Experimental Gerontology 147, pages 111263.
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Lingjing Lu, Juan Li, Yu Zhou, Hongxia Ma & Min Hu. (2021) Complementary and Alternative Medicine for Threatened Miscarriage: Advantages and Risks. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-26.
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Khaled A. Abdelrahman, Abdelrady S. Ibrahim, Ayman M. Osman, Mohamed G. Aly, Abdelhady S. Ali & Waleed S. Farrag. (2021) Alpha lipoic acid with pulsed radiofrequency in treatment of chronic lumbosacral radicular pain. Medicine 100:24, pages e26344.
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Hongjian Dai, Zengpeng Lv, Chenhui Hu, Zhicheng Shi, Xihui Wei, Song Jin, Yunwei Yuan, Debing Yu & Fangxiong Shi. (2020) Alpha‐lipoic acid improves the reproduction performance of breeder hens during the late egg‐laying period. Journal of Animal Physiology and Animal Nutrition 104:6, pages 1788-1797.
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Elham Asa, Rahim Ahmadi, Minoo Mahmoodi & Abdolreza Mohammadniya. (2020) Supplementation of freezing media with alpha lipoic acid preserves the structural and functional characteristics of sperm against cryodamage in infertile men with asthenoteratozoospermia. Cryobiology 96, pages 166-174.
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Feyyaz Özel, Müge Kiray, Aslı Göker, Selma Aydemir & Serap Cilaker Mıcılı. (2020) Protective effect of alpha lipoic acid on 4-vinylcyclohexene diepoxide induced primary ovarian failure in female rats. Taiwanese Journal of Obstetrics and Gynecology 59:2, pages 293-300.
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Saba Mokhtari, Amir Hossein Mahdavi, Mehdi Hajian, Rasoul Kowsar, Shiva Rouhollahi Varnosfaderani & Mohammad Hossein Nasr-Esfahani. (2020) The attenuation of the toxic effects of LPS on mouse pre-implantation development by alpha-lipoic acid. Theriogenology 143, pages 139-147.
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Beata Skibska & Anna Gorąca. (2019) Perspectives on the use of lipoic acid in the support of disease treatment*. Postępy Higieny i Medycyny Doświadczalnej 73, pages 483-490.
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Fiorella Di Nicuolo, Silvia D'Ippolito, Roberta Castellani, Esther Diana Rossi, Valeria Masciullo, Monia Specchia, Marco Mariani, Alfredo Pontecorvi, Giovanni Scambia & Nicoletta Di Simone. (2019) Effect of alpha‐lipoic acid and myoinositol on endometrial inflammasome from recurrent pregnancy loss women. American Journal of Reproductive Immunology 82:3.
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Gloria Formoso, Maria P.A. Baldassarre, Federica Ginestra, Maria Assunta Carlucci, Ines Bucci & Agostino Consoli. (2019) Inositol and antioxidant supplementation: Safety and efficacy in pregnancy. Diabetes/Metabolism Research and Reviews 35:5.
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Hadise Aslfalah, Mehri Jamilian, Fatemeh Rafiei & Ali Khosrowbeygi. (2019) Reduction in maternal serum values of glucose and gamma-glutamyltransferase after supplementation with alpha-lipoic acid in women with gestational diabetes mellitus. Journal of Obstetrics and Gynaecology Research 45:2, pages 313-317.
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Serap Cilaker Micili, Asli Goker, Kemal Kuscu, Bekir Ugur Ergur & Andrea Fuso. (2019) α-Lipoic Acid Vaginal Administration Contrasts Inflammation and Preterm Delivery in Rats. Reproductive Sciences 26:1, pages 128-138.
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Aleksandra Uskoković, Svetlana Dinić, Jelena Arambašić Jovanović, Goran Poznanović, Melita Vidaković & Mirjana Mihailović. 2019. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 1121 1141 .
D. Fratantonio, A. Speciale, M.S. Molonia, R. Bashllari, M. Palumbo, A. Saija, F. Cimino, G. Monastra & F. Virgili. (2018) Alpha-lipoic acid, but not di-hydrolipoic acid, activates Nrf2 response in primary human umbilical-vein endothelial cells and protects against TNF-α induced endothelium dysfunction. Archives of Biochemistry and Biophysics 655, pages 18-25.
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Usama Ahmed Fahmy & Bader Mubarak Aljaeid. (2018) Tadalafil Transdermal Delivery with Alpha-lipoic Acid Self Nanoemulsion for Treatment of Erectile Dysfunction by Diabetes Mellitus. International Journal of Pharmacology 14:7, pages 945-951.
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Bader Mubarak Aljaeid & Mohamed Ahmed El-Moselhy. (2018) Loading of Gentamicin and Alpha Lipoic Acid on a Biodegradable Polymer for More Effective and Less Nephrotoxic Formula. International Journal of Pharmacology 14:6, pages 796-801.
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Aleksandra Uskoković, Svetlana Dinić, Jelena Arambašić Jovanović, Goran Poznanović, Melita Vidaković & Mirjana Mihailović. 2017. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 1 21 .
Simona Dinicola, Sara Proietti, Alessandra Cucina, Mariano Bizzarri & Andrea Fuso. (2017) Alpha-Lipoic Acid Downregulates IL-1β and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells. Antioxidants 6:4, pages 74.
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Simona Dinicola, Myselis Santiago-Reyes, Rita Canipari, Alessandra Cucina, Mariano Bizzarri & Andrea Fuso. (2017) Alpha-lipoic acid represses IL-1B and IL-6 through DNA methylation in ovarian cells. PharmaNutrition 5:3, pages 77-83.
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Mino Caira, Susan Bourne & Buntubonke Mzondo. (2017) Encapsulation of the Antioxidant R-(+)-α-Lipoic Acid in Permethylated α- and β-Cyclodextrins: Thermal and X-ray Structural Characterization of the 1:1 Inclusion Complexes. Molecules 22:6, pages 866.
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