639
Views
31
CrossRef citations to date
0
Altmetric
Review

Inhaled gene delivery: a formulation and delivery approach

, , , , & ORCID Icon
Pages 319-330 | Received 29 May 2016, Accepted 15 Jul 2016, Published online: 05 Aug 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Conor A. Ruzycki, Derek Montoya, Hammad Irshad, Jason Cox, Yue Zhou, Jacob D. McDonald & Philip J. Kuehl. (2023) Inhalation delivery of nucleic acid gene therapies in preclinical drug development. Expert Opinion on Drug Delivery 20:8, pages 1097-1113.
Read now
Javier Garcia Gonzalez & Frank J. Hernandez. (2022) Nuclease activity: an exploitable biomarker in bacterial infections. Expert Review of Molecular Diagnostics 22:3, pages 265-294.
Read now
Larissa Gomes dos Reis & Daniela Traini. (2020) Advances in the use of cell penetrating peptides for respiratory drug delivery. Expert Opinion on Drug Delivery 17:5, pages 647-664.
Read now
Larissa Gomes dos Reis, Wing-Hin Lee, Maree Svolos, Lyn M. Moir, Rima Jaber, Andrea Engel, Norbert Windhab, Paul M. Young & Daniela Traini. (2020) Delivery of pDNA to lung epithelial cells using PLGA nanoparticles formulated with a cell-penetrating peptide: understanding the intracellular fate. Drug Development and Industrial Pharmacy 46:3, pages 427-442.
Read now
Peter Riddell, Jennifer L. Gilbert, Emer L. Molloy, Shane Finnegan, Jim J. Egan & Shirley O’Dea. (2018) Delivery of nucleic acids to ex vivo porcine airways using electrospray. Experimental Lung Research 44:8-9, pages 405-416.
Read now

Articles from other publishers (26)

Yunze Tian, Hongyang Shi, Danjie Zhang, Chenfei Wang, Feng Zhao, Liang Li, Zhengshui Xu, Jiantao Jiang & Jianzhong Li. (2023) Nebulized inhalation of LPAE-HDAC10 inhibits acetylation-mediated ROS/NF-κB pathway for silicosis treatment. Journal of Controlled Release 364, pages 618-631.
Crossref
Kyung Hwa Chang, Bong Joo Park & Ki Chang Nam. (2023) Aerosolization Performance of Immunoglobulin G by Jet and Mesh Nebulizers. AAPS PharmSciTech 24:5.
Crossref
Hezhi Wang, Lu Qin, Xin Zhang, Jian Guan & Shirui Mao. (2022) Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery. Journal of Controlled Release 352, pages 970-993.
Crossref
Miftakul Munir, Herlan Setiawan, Rohadi Awaludin & Vicky L. Kett. (2022) Aerosolised micro and nanoparticle: formulation and delivery method for lung imaging. Clinical and Translational Imaging 11:1, pages 33-50.
Crossref
Dimitrios Skoulas, Sarinj Fattah, Dandan Wang, Sally‐Ann Cryan & Andreas Heise. (2022) Systematic Study of Enzymatic Degradation and Plasmid DNA Complexation of Mucus Penetrating Star‐Shaped Lysine/Sarcosine Polypept(o)ides with Different Block Arrangements. Macromolecular Bioscience 22:8, pages 2200175.
Crossref
Miftakul Munir, Vicky L. Kett, Nicholas J. Dunne & Helen O. McCarthy. (2022) Development of a Spray-Dried Formulation of Peptide-DNA Nanoparticles into a Dry Powder for Pulmonary Delivery Using Factorial Design. Pharmaceutical Research 39:6, pages 1215-1232.
Crossref
M. Munir, L. Jena, V.L. Kett, N.J. Dunne & H.O. McCarthy. (2022) Spray drying: Inhalable powders for pulmonary gene therapy. Biomaterials Advances 133, pages 112601.
Crossref
Heidrun Steinle, Josefin Weber, Sandra Stoppelkamp, Katharina Große-Berkenbusch, Sonia Golombek, Marbod Weber, Tuba Canak-Ipek, Sarah-Maria Trenz, Christian Schlensak & Meltem Avci-Adali. (2021) Delivery of synthetic mRNAs for tissue regeneration. Advanced Drug Delivery Reviews 179, pages 114007.
Crossref
Srushti J. Sodha, Manan Patel, Rigved Nagarkar, Irfan A. Mohammed & Hiren Patel. (2021) Translation of pulmonary protein therapy from bench to bedside: Addressing the bioavailability challenges. Journal of Drug Delivery Science and Technology 64, pages 102664.
Crossref
Myriam Sainz-Ramos, Idoia Gallego, Ilia Villate-Beitia, Jon Zarate, Iván Maldonado, Gustavo Puras & Jose Luis Pedraz. (2021) How Far Are Non-Viral Vectors to Come of Age and Reach Clinical Translation in Gene Therapy?. International Journal of Molecular Sciences 22:14, pages 7545.
Crossref
Daiqin Chen, Shuai Liu, Dinghao Chen, Jinhao Liu, Jerry Wu, Han Wang, Yun Su, Gijung Kwak, Xinyuan Zuo, Divya Rao, Honggang Cui, Chunying Shu & Jung Soo Suk. (2021) A Two‐Pronged Pulmonary Gene Delivery Strategy: A Surface‐Modified Fullerene Nanoparticle and a Hypotonic Vehicle. Angewandte Chemie International Edition 60:28, pages 15225-15229.
Crossref
Daiqin Chen, Shuai Liu, Dinghao Chen, Jinhao Liu, Jerry Wu, Han Wang, Yun Su, Gijung Kwak, Xinyuan Zuo, Divya Rao, Honggang Cui, Chunying Shu & Jung Soo Suk. (2021) A Two‐Pronged Pulmonary Gene Delivery Strategy: A Surface‐Modified Fullerene Nanoparticle and a Hypotonic Vehicle. Angewandte Chemie 133:28, pages 15353-15357.
Crossref
Salsabil Elboraie, Konstantinos N. Kafetzis, Rajeev Shrivastava & Aristides D. Tagalakis. 2021. Cystic Fibrosis - Facts, Management and Advances. Cystic Fibrosis - Facts, Management and Advances.
Rachel Yoon Kyung Chang, Michael Y.T. Chow, Dipesh Khanal, Donghao Chen & Hak-Kim Chan. (2021) Dry powder pharmaceutical biologics for inhalation therapy. Advanced Drug Delivery Reviews 172, pages 64-79.
Crossref
Yaseen Hussain, Jing-Hao Cui, Haroon Khan, Pooyan Makvandi & Waqas Alam. (2021) Biomacromolecule-mediated pulmonary delivery of siRNA and anti-sense oligos: challenges and possible solutions. Expert Reviews in Molecular Medicine 23.
Crossref
Huibi Cao, Hong Ouyang, Onofrio Laselva, Claire Bartlett, Zhichang Peter Zhou, Cathleen Duan, Tarini Gunawardena, Julie Avolio, Christine E. Bear, Tanja Gonska, Jim Hu & Theo J. Moraes. (2020) A helper-dependent adenoviral vector rescues CFTR to wild-type functional levels in cystic fibrosis epithelial cells harbouring class I mutations. European Respiratory Journal 56:5, pages 2000205.
Crossref
The-Thien Tran, Nur Amalina, Wean Sin Cheow & Kunn Hadinoto. (2020) Effects of storage on the stability and aerosolization efficiency of dry powder inhaler formulation of plasmid DNA-Chitosan nanoparticles. Journal of Drug Delivery Science and Technology 59, pages 101866.
Crossref
Myriam Sainz-Ramos, Nuseibah AL Qtaish, Idoia Gallego, Ilia Villate- Beitia, Tania López, Gustavo Puras & José Luis Pedraz. 2019. In Vivo and Ex Vivo Gene Therapy for Inherited and Non-Inherited Disorders. In Vivo and Ex Vivo Gene Therapy for Inherited and Non-Inherited Disorders.
Maliheh Ghadiri, Paul Young & Daniela Traini. (2019) Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes. Pharmaceutics 11:3, pages 113.
Crossref
Nazrul Islam & Derek Richard. (2019) Inhaled Micro/Nanoparticulate Anticancer Drug Formulations: An Emerging Targeted Drug Delivery Strategy for Lung Cancers. Current Cancer Drug Targets 19:3, pages 162-178.
Crossref
Larissa Gomes dos Reis, Wing-Hin Lee, Maree Svolos, Lyn Margaret Moir, Rima Jaber, Norbert Windhab, Paul Michael Young & Daniela Traini. (2019) Nanotoxicologic Effects of PLGA Nanoparticles Formulated with a Cell-Penetrating Peptide: Searching for a Safe pDNA Delivery System for the Lungs. Pharmaceutics 11:1, pages 12.
Crossref
Treniece L. Terry, Brittany E. Givens, Victor G. J. Rodgers & Aliasger K. Salem. (2019) Tunable Properties of Poly-DL-Lactide-Monomethoxypolyethylene Glycol Porous Microparticles for Sustained Release of Polyethylenimine-DNA Polyplexes. AAPS PharmSciTech 20:1.
Crossref
Larissa Gomes dos Reis, Maree Svolos, Lyn M Moir, Rima Jaber, Norbert Windhab, Paul M Young & Daniela Traini. (2018) Delivery of pDNA Polyplexes to Bronchial and Alveolar Epithelial Cells Using a Mesh Nebulizer. Pharmaceutical Research 36:1.
Crossref
Jing Chen, Yue Tang, Yun Liu & Yushun Dou. (2018) Nucleic Acid-Based Therapeutics for Pulmonary Diseases. AAPS PharmSciTech 19:8, pages 3670-3680.
Crossref
Stephen P. Newman. (2018) Delivering drugs to the lungs: The history of repurposing in the treatment of respiratory diseases. Advanced Drug Delivery Reviews 133, pages 5-18.
Crossref
Angélique Mottais, Mathieu Berchel, Yann Sibiril, Véronique Laurent, Deborah Gill, Stephen Hyde, Paul-Alain Jaffrès, Tristan Montier & Tony Le Gall. (2018) Antibacterial effect and DNA delivery using a combination of an arsonium-containing lipophosphoramide with an N-heterocyclic carbene-silver complex – Potential benefits for cystic fibrosis lung gene therapy. International Journal of Pharmaceutics 536:1, pages 29-41.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.