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Expert Opinion on Drug Delivery Volume 16, 2019 - Issue 2
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Review

Subcutaneous delivery of biotherapeutics: challenges at the injection site

Joana A. D. SequeiraDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, PortugalORCID Iconhttps://orcid.org/0000-0002-3654-3862View further author information
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Ana C. SantosDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal;REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, PortugalORCID Iconhttps://orcid.org/0000-0003-2710-6000View further author information
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João SerraTecnimede, Sociedade Técnico-Medicinal, Sintra, PortugalView further author information
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Catarina EstevensTecnimede, Sociedade Técnico-Medicinal, Sintra, PortugalView further author information
,
Raquel SeiçaInstitute of Physiology, Faculty of Medicine, University of Coimbra, Coimbra, PortugalView further author information
,
Francisco VeigaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal;REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, PortugalORCID Iconhttps://orcid.org/0000-0002-1041-0068View further author information
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António J. RibeiroDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal;i3S, Group Genetics of Cognitive Dysfunction, Institute for Molecular and Cell Biology, Porto, PortugalCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1399-8944View further author information
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Pages 143-151 | Received 06 Jul 2018, Accepted 08 Jan 2019, Published online: 24 Jan 2019

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B. Rama & A. J. Ribeiro. (2023) Role of nanotechnology in the prolonged release of drugs by the subcutaneous route. Expert Opinion on Drug Delivery 20:5, pages 559-577.
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Christopher J. Rini, Bruce C. Roberts, Aishwarya Vaidyanathan, Aojun Li, Rick Klug, Douglas B. Sherman & Ronald J. Pettis. (2022) Enabling faster subcutaneous delivery of larger volume, high viscosity fluids. Expert Opinion on Drug Delivery 19:9, pages 1165-1176.
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Simone Esposito, Laura Orsatti & Vincenzo Pucci. (2022) Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations. Xenobiotica 52:8, pages 828-839.
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Salla Valtonen, Emmiliisa Vuorinen, Ville Eskonen, Morteza Malakoutikhah, Kari Kopra & Harri Härmä. (2021) Sensitive, homogeneous, and label-free protein-probe assay for antibody aggregation and thermal stability studies. mAbs 13:1.
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John P. Koulakis, Joshua Rouch, Nhan Huynh, Holden H. Wu, James C. Y. Dunn & Seth Putterman. (2020) Tumescent Injections in Subcutaneous Pig Tissue Disperse Fluids Volumetrically and Maintain Elevated Local Concentrations of Additives for Several Hours, Suggesting a Treatment for Drug Resistant Wounds. Pharmaceutical Research 37:3.
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