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Expert Opinion on Drug Delivery Volume 16, 2019 - Issue 6
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Original Research

Polymeric micelle nanocarriers for targeted epidermal delivery of the hedgehog pathway inhibitor vismodegib: formulation development and cutaneous biodistribution in human skin

Somnath G. KandekarSchool of Pharmaceutical Sciences, University of Geneva & University of Lausanne, Geneva, SwitzerlandView further author information
,
Mayank SinghalSchool of Pharmaceutical Sciences, University of Geneva & University of Lausanne, Geneva, SwitzerlandView further author information
,
Kiran B. SonajeSchool of Pharmaceutical Sciences, University of Geneva & University of Lausanne, Geneva, SwitzerlandView further author information
&
Yogeshvar N. KaliaSchool of Pharmaceutical Sciences, University of Geneva & University of Lausanne, Geneva, SwitzerlandCorrespondence[email protected]
View further author information
Pages 667-674 | Received 02 Feb 2019, Accepted 16 Apr 2019, Published online: 26 Apr 2019

Citations (21)

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Yang Chen, Xun Feng & Shengnan Meng. (2019) Site-specific drug delivery in the skin for the localized treatment of skin diseases. Expert Opinion on Drug Delivery 16:8, pages 847-867.
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Articles from other publishers (20)

E.T. Aguayo Frías, D. Maza Vega, M.N. Calienni, C. Lillo, D.S. Vazquez, S.d.V. Alonso & J. Montanari. (2023) Enhanced skin delivery of vismodegib-loaded rigid liposomes combined with ethosomes. OpenNano 14, pages 100186.
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Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Won Sun Park, Jin-Hee Han, Yong-Soo Kwon, Hee-Jae Lee & Wanjoo Chun. (2023) Vismodegib Identified as a Novel COX-2 Inhibitor via Deep-Learning-Based Drug Repositioning and Molecular Docking Analysis. ACS Omega.
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Aditya R. Darade, Maria Lapteva, Vincent Ling & Yogeshvar N. Kalia. (2023) Polymeric micelles for cutaneous delivery of the hedgehog pathway inhibitor TAK-441: Formulation development and cutaneous biodistribution in porcine and human skin. International Journal of Pharmaceutics 644, pages 123349.
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Jiangxiu Niu, Ming Yuan, Jingjing Chen, Liye Wang, Yueheng Qi, Kaiyue Bai, Yanli Fan & Panpan Gao. (2023) L-Cysteine-Modified Transfersomes for Enhanced Epidermal Delivery of Podophyllotoxin. Molecules 28:15, pages 5712.
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Julie Quartier, Maria Lapteva, Younes Boulaguiem, Stéphane Guerrier & Yogeshvar N. Kalia. (2023) Influence of Molecular Structure and Physicochemical Properties of Immunosuppressive Drugs on Micelle Formulation Characteristics and Cutaneous Delivery. Pharmaceutics 15:4, pages 1278.
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Moong Yan Leong, Yeo Lee Kong, Kevin Burgess, Won Fen Wong, Gautam Sethi & Chung Yeng Looi. (2023) Recent Development of Nanomaterials for Transdermal Drug Delivery. Biomedicines 11:4, pages 1124.
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Kristian Kåber Pedersen, Maria Helena Høyer-Hansen, Thomas Litman, Merete Hædersdal & Uffe Høgh Olesen. (2022) Topical Delivery of Hedgehog Inhibitors: Current Status and Perspectives. International Journal of Molecular Sciences 23:22, pages 14191.
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Jiangxiu Niu, Ming Yuan, Zhaowei Zhang, Liye Wang, Yanli Fan, Xianghui Liu, Xianming Liu, Huiyuan Ya, Yansong Zhang & Yang Xu. (2022) Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin. International Journal of Nanomedicine Volume 17, pages 4009-4022.
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Ibrahim A. Aljuffali, Chih-Hung Lin, Shih-Chun Yang, Ahmed Alalaiwe & Jia-You Fang. (2022) Nanoencapsulation of Tea Catechins for Enhancing Skin Absorption and Therapeutic Efficacy. AAPS PharmSciTech 23:6.
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Rupesh Jain, Sunil Kumar Dubey & Gautam Singhvi. (2022) The Hedgehog pathway and its inhibitors: Emerging therapeutic approaches for basal cell carcinoma. Drug Discovery Today 27:4, pages 1176-1183.
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Julie Quartier, Wei Rao, Susan Slade, Frédéric Métral, Maria Lapteva & Yogeshvar N. Kalia. (2021) DESI-MS imaging to visualize spatial distribution of xenobiotics and endogenous lipids in the skin. International Journal of Pharmaceutics 607, pages 120967.
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Natalie Kash & Sirunya Silapunt. (2021) A review of emerging and non-US FDA-approved topical agents for the treatment of basal cell carcinoma. Future Oncology 17:23, pages 3111-3132.
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Julie Quartier, Maria Lapteva, Younes Boulaguiem, Stéphane Guerrier & Yogeshvar N. Kalia. (2021) Polymeric micelle formulations for the cutaneous delivery of sirolimus: A new approach for the treatment of facial angiofibromas in tuberous sclerosis complex. International Journal of Pharmaceutics 604, pages 120736.
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Sevgi Güngör & Emine Kahraman. (2021) Nanocarriers Mediated Cutaneous Drug Delivery. European Journal of Pharmaceutical Sciences 158, pages 105638.
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Maria Natalia Calienni, Daniela Maza Vega, C. Facundo Temprana, María Cecilia Izquierdo, David E. Ybarra, Ezequiel Bernabeu, Marcela Moretton, Fernando C. Alvira, Diego Chiappetta, Silvia del Valle Alonso, María Jimena Prieto & Jorge Montanari. (2021) The Topical Nanodelivery of Vismodegib Enhances Its Skin Penetration and Performance In Vitro While Reducing Its Toxicity In Vivo. Pharmaceutics 13:2, pages 186.
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Uffe Høgh Olesen, Gael Clergeaud, Kristoffer Kjærgaard Hendel, Kelvin Yeung, Catharina Margrethe Lerche, Thomas Lars Andresen & Merete Haedersdal. (2020) Enhanced and Sustained Cutaneous Delivery of Vismodegib by Ablative Fractional Laser and Microemulsion Formulation. Journal of Investigative Dermatology 140:10, pages 2051-2059.
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Pratheeksha Koppa Raghu, Kuldeep K. Bansal, Pradip Thakor, Valamla Bhavana, Jitender Madan, Jessica M. Rosenholm & Neelesh Kumar Mehra. (2020) Evolution of Nanotechnology in Delivering Drugs to Eyes, Skin and Wounds via Topical Route. Pharmaceuticals 13:8, pages 167.
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Christian Gorzelanny, Christian Mess, Stefan W. Schneider, Volker Huck & Johanna M. Brandner. (2020) Skin Barriers in Dermal Drug Delivery: Which Barriers Have to Be Overcome and How Can We Measure Them?. Pharmaceutics 12:7, pages 684.
Crossref
Vasundhara Tyagi, Sergio del Río-Sancho, Maria Lapteva & Yogeshvar N. Kalia. (2019) Topical iontophoresis of buflomedil hydrochloride increases drug bioavailability in the mucosa: A targeted approach to treat oral submucous fibrosis. International Journal of Pharmaceutics 569, pages 118610.
Crossref
Julie Quartier, Ninon Capony, Maria Lapteva & Yogeshvar N. Kalia. (2019) Cutaneous Biodistribution: A High-Resolution Methodology to Assess Bioequivalence in Topical Skin Delivery. Pharmaceutics 11:9, pages 484.
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