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Expert Opinion on Drug Delivery Volume 17, 2020 - Issue 2
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Original Research

Enhanced oral bioavailability and hepatoprotective activity of thymoquinone in the form of phospholipidic nano-constructs

C. RathoreSchool of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, IndiaView further author information
,
N. UpadhyaySchool of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, IndiaView further author information
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R. KaundalIcahn School of Medicine, Mount Sinai, Hospital and Healthcare, New York, NY, USAView further author information
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R. P. DwivediSchool of Electrical and Computer Science Engineering, Shoolini University of Biotechnology and Management Sciences, Solan, IndiaView further author information
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S. RahatekarCranfield University, Cranfield, UKView further author information
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A. JohnLaboratory of Materials Science, Institute of Chemistry of Natural Resource, University of Talca, Talca, ChileView further author information
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K. DuaDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Australia;School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, Australia;Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Newcastle, AustraliaView further author information
,
Murtaza M. TambuwalaSchool of Pharmacy & Pharmaceutical Sciences, Faculty of Life & Health Sciences, Ulster University, Coleraine, UKORCID Iconhttps://orcid.org/0000-0001-8499-9891View further author information
ORCID Icon,
S. JainDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Centre for Pharmaceutical Nanotechnology, Punjab, IndiaView further author information
,
D. ChaudariDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Centre for Pharmaceutical Nanotechnology, Punjab, IndiaView further author information
&
P. NegiSchool of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, IndiaCorrespondence[email protected]
View further author information
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Pages 237-253 | Received 08 Jul 2019, Accepted 13 Jan 2020, Published online: 31 Jan 2020

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Charul Rathore, Michael J Rathbone, Dinesh K Chellappan, Murtaza M Tambuwala, Terezinha De Jesus A Pinto, Harish Dureja, Chetna Hemrajani, Gaurav Gupta, Kamal Dua & Poonam Negi. (2020) Nanocarriers: more than tour de force for thymoquinone. Expert Opinion on Drug Delivery 17:4, pages 479-494.
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Articles from other publishers (13)

Ambreen Shoaib, Shamama Javed, Shadma Wahab, Lubna Azmi, Mohammad Tabish, Muhammad H. Sultan, Karim Abdelsalam, Saad S. Alqahtani & Md Faruque Ahmad. (2023) Cellular, Molecular, Pharmacological, and Nano-Formulation Aspects of Thymoquinone—A Potent Natural Antiviral Agent. Molecules 28:14, pages 5435.
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Zhanxue Zhao, Linxun Liu, Shuai Li, Xiaofan Hou & Jinyu Yang. (2023) Advances in research on the relationship between thymoquinone and pancreatic cancer. Frontiers in Oncology 12.
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Charul Rathore, Chetna Hemrajani, Abhishek Kumar Sharma, Piyush Kumar Gupta, Niraj Kumar Jha, Alaa A. A. Aljabali, Gaurav Gupta, Sachin Kumar Singh, Jen-Chang Yang, Ram Prakash Dwivedi, Kamal Dua, Dinesh Kumar Chellappan, Poonam Negi & Murtaza M. Tambuwala. (2022) Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies. Drug Delivery and Translational Research 13:1, pages 292-307.
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Gajendran Nithya, Rajasekaran Santhanasabapathy, Manickam Kalappan Vanitha, Pandi Anandakumar & Dhanapalan Sakthisekaran. (2022) Antioxidant, antiproliferative, and apoptotic activity of thymoquinone against benzo( a )pyrene‐induced experimental lung cancer . Journal of Biochemical and Molecular Toxicology 37:1.
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Pratik Kharat, Padakanti Sandeep Chary, Valamla Bhavana, Naveen Rajana, Geetanjali Devabattula, Chandraiah Godugu, Shashi Bala Singh & Neelesh Kumar Mehra. (2022) Thymoquinone-Loaded Essential Oil–Based Emulgel as an Armament for Anti-psoriatic Activity. AAPS PharmSciTech 24:1.
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Keith W. Singletary. (2022) Black Seeds. Nutrition Today 57:6, pages 348-366.
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Monica Butnariu, Cristina Quispe, Jesús Herrera-Bravo, Paweł Helon, Wirginia Kukula-Koch, Víctor López, Francisco Les, Cristian Valdés Vergara, Pedro Alarcón-Zapata, Barbara Alarcón-Zapata, Miquel Martorell, Marius Pentea, Aneta Anca Dragunescu, Ionel Samfira, Zura Yessimsiitova, Sevgi Durna Daştan, Carla Marina Salgado Castillo, Thomas H. Roberts, Javad Sharifi-Rad, Wojciech Koch & William C. Cho. (2022) The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies. Biomedicine & Pharmacotherapy 153, pages 113364.
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Yinghao Zheng, Yun Wang, Mengyu Xia, Ya Gao, Lan Zhang, Yanan Song & Cun Zhang. (2021) The combination of nanotechnology and traditional Chinese medicine (TCM) inspires the modernization of TCM: review on nanotechnology in TCM-based drug delivery systems. Drug Delivery and Translational Research 12:6, pages 1306-1325.
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Poonam Negi, Surbhi Gautam, Aditi Sharma, Charul Rathore, Lalit Sharma, Navneet Upadhyay, Murtaza M Tambuwala, Dinesh Kumar Chellappan, Gaurav Gupta, Parteek Prasher, Kamal Dua, Shweta Agarwal & Uma Ranjan Lal. (2022) Gastric ulcer healing by chebulinic acid solid dispersion-loaded gastroretentive raft systems: preclinical evidence. Therapeutic Delivery 13:2, pages 81-93.
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Min Liu, Qiong Huang, Yan Zhu, Li Chen, Yumei Li, Zhicheng Gong & Kelong Ai. (2022) Harnessing reactive oxygen/nitrogen species and inflammation: Nanodrugs for liver injury. Materials Today Bio 13, pages 100215.
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Md Rizwanullah, Ahmad Perwez, Showkat Rasool Mir, Mohd Moshahid Alam Rizvi & Saima Amin. (2021) Exemestane encapsulated polymer-lipid hybrid nanoparticles for improved efficacy against breast cancer: optimization, in vitro characterization and cell culture studies. Nanotechnology 32:41, pages 415101.
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Md. Abdul Hannan, Md. Ataur Rahman, Abdullah Al Mamun Sohag, Md. Jamal Uddin, Raju Dash, Mahmudul Hasan Sikder, Md. Saidur Rahman, Binod Timalsina, Yeasmin Akter Munni, Partha Protim Sarker, Mahboob Alam, Md. Mohibbullah, Md. Nazmul Haque, Israt Jahan, Md. Tahmeed Hossain, Tania Afrin, Md. Mahbubur Rahman, Md. Tahjib-Ul-Arif, Sarmistha Mitra, Diyah Fatimah Oktaviani, Md Kawsar Khan, Ho Jin Choi, Il Soo Moon & Bonglee Kim. (2021) Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety. Nutrients 13:6, pages 1784.
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Khaled AbouAitah & Witold Lojkowski. (2021) Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy. Pharmaceutics 13:2, pages 143.
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