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Pharmacogenomics of triazole antifungal agents: implications for safety, tolerability and efficacy

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Pages 1135-1146 | Received 06 Jul 2017, Accepted 09 Oct 2017, Published online: 20 Oct 2017

Keep up to date with the latest research on this topic with citation updates for this article.

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Irene García-García & Alberto M. Borobia. (2021) Current approaches and future strategies for the implementation of pharmacogenomics in the clinical use of azole antifungal drugs. Expert Opinion on Drug Metabolism & Toxicology 17:5, pages 509-514.
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Jamie John, Angela Loo, Shawn Mazur & Thomas J. Walsh. (2019) Therapeutic drug monitoring of systemic antifungal agents: a pragmatic approach for adult and pediatric patients. Expert Opinion on Drug Metabolism & Toxicology 15:11, pages 881-895.
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David Boels, Stéphanie Chhun, Géraldine Meyer, Bénédicte Lelièvre & Vincent Souday. (2019) Clinical consequences related to a defective elimination of clobazam caused by homozygous mutated CYP2C19 allele. Clinical Toxicology 57:8, pages 743-747.
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Dan Lou, Xiao Cui, Su-Su Bao, Wei Sun, Wen-He Pan, Meng-Chun Chen, Yao-Yao Dong, Guo-Xin Hu, Rui-Jie Chen & Zhe Wang. (2019) Effects of ketoconazole, voriconazole, and itraconazole on the pharmacokinetics of apatinib in rats. Drug Development and Industrial Pharmacy 45:4, pages 689-693.
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Guolin Li, Qinhui Li, Changji Zhang, Qin Yu, Qi Li, Xiaoshi Zhou, Rou Yang, Xuerong Yang, Hailin Liu & Yong Yang. (2023) The impact of gene polymorphism and hepatic insufficiency on voriconazole dose adjustment in invasive fungal infection individuals. Frontiers in Genetics 14.
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Domenico Iacopetta, Jessica Ceramella, Alessia Catalano, Elisabetta Scali, Domenica Scumaci, Michele Pellegrino, Stefano Aquaro, Carmela Saturnino & Maria Stefania Sinicropi. (2023) Impact of Cytochrome P450 Enzymes on the Phase I Metabolism of Drugs. Applied Sciences 13:10, pages 6045.
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Amin Rakhshan, Bardia Rahmati Kamel, Ali Saffaei & Maria Tavakoli-Ardakani. (2023) Hepatotoxicity Induced by Azole Antifungal Agents: A Review Study. Iranian Journal of Pharmaceutical Research 22:1.
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Ting Zhao, Hao Shen, Hui-lan Zhang, Jie Feng, Si-ming Liu, Ting-ting Wang, Hong-jian Li & Lu-hai Yu. (2023) Association of CYP2C19 , CYP3A4 and ABCC2 polymorphisms and voriconazole plasma concentrations in Uygur pediatric patients . Pharmacogenomics 24:3, pages 141-151.
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Frederic Lamoth & Thierry Calandra. (2022) Pulmonary aspergillosis: diagnosis and treatment. European Respiratory Review 31:166, pages 220114.
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Jianxing Zhou, Zipeng Wei, Baohua Xu, Maobai Liu, Ruichao Xu & Xuemei Wu. (2022) Pharmacovigilance of triazole antifungal agents: Analysis of the FDA adverse event reporting system (FAERS) database. Frontiers in Pharmacology 13.
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Yishuo Shu, Yinping Shi, Yilei Yang, Zhonghua Dong, Qiaoyan Yi & Haiyan Shi. (2022) Progress of triazole antifungal agent posaconazole in individualized therapy. Journal of Clinical Pharmacy and Therapeutics 47:12, pages 1966-1981.
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Yoshio Takesue, Yuki Hanai, Kazutaka Oda, Yukihiro Hamada, Takashi Ueda, Toshihiko Mayumi, Kazuaki Matsumoto, Satoshi Fujii, Yoshiko Takahashi, Yoshitsugu Miyazaki & Toshimi Kimura. (2022) Clinical Practice Guideline for the Therapeutic Drug Monitoring of Voriconazole in Non-Asian and Asian Adult Patients: Consensus Review by the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring. Clinical Therapeutics 44:12, pages 1604-1623.
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Lu Chen, Lixian Li & Wanyi Chen. (2022) Use of Modeling and Simulation to Predict the Influence of Triazole Antifungal Agents on the Pharmacokinetics of Crizotinib. Clinical Pharmacology in Drug Development 11:6, pages 724-733.
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Bereda Gudisa. (2022) Antimycolytic agents: fungistatic and fungicide. Annals of Dermatological Research 6:1, pages 001-009.
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Sumaiya Tabassum & Santhosh Govindaraju. (2022) White LED Light-Mediated Eosin Y-Photocatalyzed One-Pot Synthesis of Novel 1,2,4-Triazol-3-Amines By Sequential Addition. Topics in Catalysis.
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Marwa H. El-Wakil, Mohamed Teleb, Marwa.M. Abu-Serie, Sun Huang, Gerald W. Zamponi & Hesham Fahmy. (2021) Structural optimization, synthesis and in vitro synergistic anticancer activities of combinations of new N3-substituted dihydropyrimidine calcium channel blockers with cisplatin and etoposide. Bioorganic Chemistry 115, pages 105262.
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D. Wilmes, E. Coche, H. Rodriguez-Villalobos & N. Kanaan. (2021) Fungal pneumonia in kidney transplant recipients. Respiratory Medicine 185, pages 106492.
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Jianfu Heng, Qi Tang, Xue Chen, Jingjing Bao, Jun Deng, Yong Chen, Jiao Zhao, Songlin Zhu, Xiaobao Liu, Feng Yang, Yun Jiang, Nong Yang & Kunyan Li. (2021) Evaluation of the pharmacokinetic effects of itraconazole on alflutinib (AST2818): an open-label, single-center, single-sequence, two-period randomized study in healthy volunteers. European Journal of Pharmaceutical Sciences 162, pages 105815.
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Chaodi Luo, Xinglong Zheng, Jing Li, Yongjian Zhang, Tao Shi, Yang Yan & Dan Han. (2021) Pharmacological corrections of the mutant hERG channels by posaconazole. Clinical and Experimental Pharmacology and Physiology 48:6, pages 855-868.
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Katharina R. Beck & Alex Odermatt. (2021) Antifungal therapy with azoles and the syndrome of acquired mineralocorticoid excess. Molecular and Cellular Endocrinology 524, pages 111168.
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Vanderlan Nogueira Holanda, Welson Vicente da Silva, Pedro Henrique do Nascimento, Sérgio Ruschi Bergamachi Silva, Paulo Euzébio Cabral Filho, Shalom Porto de Oliveira Assis, César Augusto da Silva, Ronaldo Nascimento de Oliveira, Regina Celia Bressan Queiroz de Figueiredo & Vera Lucia de Menezes Lima. (2020) Antileishmanial activity of 4-phenyl-1-[2-(phthalimido-2-yl)ethyl]-1H-1,2,3-triazole (PT4) derivative on Leishmania amazonensis and Leishmania braziliensis: In silico ADMET, in vitro activity, docking and molecular dynamic simulations. Bioorganic Chemistry 105, pages 104437.
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Guangting Zeng, Linlin Wang, Lihong Shi, Huilan Li, Miaomiao Zhu, Jia Luo & Zanling Zhang. (2020) Variability of voriconazole concentrations in patients with hematopoietic stem cell transplantation and hematological malignancies: influence of loading dose, procalcitonin, and pregnane X receptor polymorphisms. European Journal of Clinical Pharmacology 76:4, pages 515-523.
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Matthew A. Miller & Yee Ming Lee. (2020) Applying Pharmacogenomics to Antifungal Selection and Dosing: Are We There Yet?. Current Fungal Infection Reports 14:1, pages 63-75.
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L. Bernal-Martínez, L. Alcazar Fuoli, B. Miguel-Revilla, A. Carvalho, M. S. Cuétara Garcia, J. Garcia-Rodriguez, C. Cunha, E. Gómez-García de la Pedrosa & A. Gomez-Lopez. (2019) High-Resolution Melting Assay for Genotyping Variants of the CYP2C19 Enzyme and Predicting Voriconazole Effectiveness. Antimicrobial Agents and Chemotherapy 63:6.
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Jarrett R. Amsden & Douglas Slain. (2019) Dosing Antifungals in Obesity: a Literature Review. Current Fungal Infection Reports 13:1, pages 21-32.
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Léa Darnaud, Fabien Lamoureux, Cendrine Godet, Sandrine Pontier, Alexia Debard, Nicolas Venisse, Pauline Martins, Didier Concordet & Peggy Gandia. (2018) Isavuconazole Kinetic Exploration for Clinical Practice. Drugs in R&D 18:4, pages 317-321.
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Claire Calmettes, Frederic Gabriel, Elodie Blanchard, Vincent Servant, Stéphane Bouchet, Nathanael Kabore, Edouard Forcade, Camille Leroyer, Audrey Bidet, Valérie Latrabe, Thibaut Leguay, Stephane Vigouroux, Reza Tabrizi, Dominique Breilh, Isabelle Accoceberry, Manuel Tunon de Lara, Arnaud Pigneux, Noel Milpied & Pierre-Yves Dumas. (2018) Breakthrough invasive aspergillosis and diagnostic accuracy of serum galactomannan enzyme immune assay during acute myeloid leukemia induction chemotherapy with posaconazole prophylaxis. Oncotarget 9:42, pages 26724-26736.
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