815
Views
17
CrossRef citations to date
0
Altmetric
Review

Misconceptions and issues regarding allometric scaling during the drug development process

Pages 843-854 | Received 02 Mar 2018, Accepted 09 Jul 2018, Published online: 19 Jul 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Karel Allegaert, Mohammad Yaseen Abbasi, Pieter Annaert & Olusola Olafuyi. (2022) Current and future physiologically based pharmacokinetic (PBPK) modeling approaches to optimize pharmacotherapy in preterm neonates. Expert Opinion on Drug Metabolism & Toxicology 18:5, pages 301-312.
Read now
Anne van Rongen, Elke HJ Krekels, Elisa AM Calvier, Saskia N de Wildt, An Vermeulen & Catherijne AJ Knibbe. (2022) An Update on the Use of Allometric and Other Scaling Methods to Scale Drug Clearance in Children: Towards Decision Tables. Expert Opinion on Drug Metabolism & Toxicology 18:2, pages 99-113.
Read now

Articles from other publishers (15)

Zhuo Li, Qing Zhang, Huan He, Ning Sun, Rui Zhang, Chang-Qing Yang & Li-Bo Zhao. (2022) Population pharmacokinetics of ruxolitinib in children with hemophagocytic lymphohistiocytosis: focus on the drug–drug interactions. Cancer Chemotherapy and Pharmacology 91:2, pages 121-132.
Crossref
Kyung Mi Kim, Byung-Moon Choi & Gyu-Jeong Noh. (2022) Population pharmacokinetic and pharmacodynamic model of propofol externally validated in Korean elderly subjects. Journal of Pharmacokinetics and Pharmacodynamics.
Crossref
Douglas S. Glazier. (2022) Variable metabolic scaling breaks the law: from ‘Newtonian’ to ‘Darwinian’ approaches. Proceedings of the Royal Society B: Biological Sciences 289:1985.
Crossref
Hyun‐Uk Kang, Kyung Mi Kim, Jae Moon Choi, Eun‐Kyung Lee, Byung‐Moon Choi, Gyu‐Jeong Noh & Seok Hwan Lee. (2022) Predictive performance of pharmacokinetic models for target concentration‐controlled infusion of cefoxitin as a prophylactic antibiotic in patients with colorectal surgery. Clinical and Experimental Pharmacology and Physiology 49:10, pages 1126-1135.
Crossref
Iftekhar Mahmood. (2022) A Simple Method for the Prediction of Human Concentration–Time Profiles and Pharmacokinetics of Antibody–Drug Conjugates (ADC) from Rats or Monkeys. Antibodies 11:2, pages 42.
Crossref
Douglas J. Eleveld, Jeroen V. Koomen, Anthony R. Absalom, Hong Su, Laura N. Hannivoort & Michel M. R. F. Struys. (2022) Allometric Scaling in Pharmacokinetic Studies in Anesthesiology. Anesthesiology 136:4, pages 609-617.
Crossref
Mandy Wan, Bruce Green, Arpana Aprameya Iyengar, Nivedita Kamath, Hamsa V. Reddy, Jyoti Sharma, Jyoti Singhal, Susan Uthup, Sudha Ekambaram, Sumithra Selvam, Greta Rait, Rukshana Shroff & Jignesh P. Patel. (2021) Population pharmacokinetics and dose optimisation of colecalciferol in paediatric patients with chronic kidney disease. British Journal of Clinical Pharmacology 88:3, pages 1223-1234.
Crossref
Karen-Margrethe Pedersen, Anna Katrina Jógvansdóttir Gradel, Trine Pagh Ludvigsen, Berit Østergaard Christoffersen, Caroline Amalie Fuglsang-Damgaard, Kristian Moss Bendtsen, Suzi Høgh Madsen, Valentina Manfé & Hanne Hoffmann Frølund Refsgaard. (2022) Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir. Translational Research 239, pages 71-84.
Crossref
Kyung Mi Kim, Sung‐Hoon Kim, Ho‐Yong Yun, Jiwon Jung, Ji‐Yeon Bang, Eun‐Kyung Lee, Byung‐Moon Choi & Gyu‐Jeong Noh. (2021) Development of a new pharmacokinetic model for target‐concentration controlled infusion of cefoxitin as a prophylactic antibiotic in colorectal surgical patients. British Journal of Clinical Pharmacology 87:12, pages 4648-4657.
Crossref
A. Parra-Coca, A. Boix-Montañés, A.C. Calpena-Campmany & H. Colom. (2021) In vivo pharmacokinetic evaluation of carprofen delivery from intra-articular nanoparticles in rabbits: A population modelling approach. Research in Veterinary Science 137, pages 235-242.
Crossref
Iftekhar Mahmood. (2021) Clinical Pharmacology of Antibody-Drug Conjugates. Antibodies 10:2, pages 20.
Crossref
Jayyoung Bae, Miyoung Kwon, Yong-Hun Lee, Eun-Kyung Lee, Byung-Moon Choi & Gyu-Jeong Noh. (2020) An allometric pharmacokinetic model and minimum effective analgesic concentration of fentanyl in patients undergoing major abdominal surgery. British Journal of Anaesthesia 125:6, pages 976-985.
Crossref
Donald M. Lamkin & Theodore GarlandJr.Jr.. (2020) Translating Preclinical Research for Exercise Oncology: Take It to the VO2max. Frontiers in Oncology 10.
Crossref
Jean Delbeke, Sebastian Haesler & Dimiter Prodanov. 2020. Neural Interface Engineering. Neural Interface Engineering 123 172 .
Janneke M. Brussee, Elke H. J. Krekels, Elisa A. M. Calvier, Semra Palić, Amin Rostami-Hodjegan, Meindert Danhof, Jeffrey S. Barrett, Saskia N. de Wildt & Catherijne A. J. Knibbe. (2019) A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children. The AAPS Journal 21:5.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.