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Expert Opinion on Drug Metabolism & Toxicology Volume 16, 2020 - Issue 2

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Review

Use of imaging to assess the activity of hepatic transporters

Irene Hernández LozanoDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, AustriaView further author information

Oliver LangerDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria;Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria;Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, AustriaCorrespondence[email protected]
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Pages 149-164 | Received 20 Nov 2019, Accepted 15 Jan 2020, Published online: 23 Jan 2020

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https://doi.org/10.1080/17425255.2020.1718107
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Angela Jeong, Catherine M. Pastor & Kim L. R. Brouwer. (2023) Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers. Pharmaceutical Research.
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Nicola Melillo, Daniel Scotcher, J. Gerry Kenna, Claudia Green, Catherine D. G. Hines, Iina Laitinen, Paul D. Hockings, Kayode Ogungbenro, Ebony R. Gunwhy, Steven Sourbron, John C. Waterton, Gunnar Schuetz & Aleksandra Galetin. (2023) Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug–Drug Interactions in Rats. Pharmaceutics 15:3, pages 896.
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Csilla Özvegy-Laczka, Orsolya Ungvári & Éva Bakos. (2023) Fluorescence-based methods for studying activity and drug-drug interactions of hepatic solute carrier and ATP binding cassette proteins involved in ADME-Tox. Biochemical Pharmacology 209, pages 115448.
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Flavia Storelli, Mengyue Yin, Aditya R. Kumar, Mayur K. Ladumor, Raymond Evers, Paresh P. Chothe, Osatohanmwen J. Enogieru, Xiaomin Liang, Yurong Lai & Jashvant D. Unadkat. (2022) The next frontier in ADME science: Predicting transporter-based drug disposition, tissue concentrations and drug-drug interactions in humans. Pharmacology & Therapeutics 238, pages 108271.
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Anne T. Nies, Elke Schaeffeler & Matthias Schwab. (2022) Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation. Pharmacology & Therapeutics 238, pages 108268.
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Yan Weng, Kari R. Fonseca, Yi-an Bi, Sumathy Mathialagan, Keith Riccardi, Elaine Tseng, Andrew J. Bessire, Mathew A. Cerny, David A. Tess, A. David Rodrigues, Amit S. Kalgutkar, John Litchfield, Li Di & Manthena V. S. Varma. (2022) Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, a First-In-Class Ketohexokinase Inhibitor for Metabolic Disorders and Nonalcoholic Fatty Liver Disease. Drug Metabolism and Disposition 50:9, pages 1312-1321.
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Kazuya Maeda & Yuichi Sugiyama. 2022. Drug Transporters. Drug Transporters 453 474 .

Yusuke Masuo, Azusa Futatsugi & Yukio Kato. 2022. Drug Transporters. Drug Transporters 413 431 .

Catherine M. Pastor & Kim L.R. Brouwer. (2022) New Pharmacokinetic Parameters of Imaging Substrates Quantified from Rat Liver Compartments. Drug Metabolism and Disposition 50:1, pages 58-64.
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Irene Hernández-Lozano, Severin Mairinger, Alexander Traxl, Michael Sauberer, Thomas Filip, Johann Stanek, Claudia Kuntner, Thomas Wanek & Oliver Langer. (2021) Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice. Pharmaceutics 13:8, pages 1286.
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Solène Marie, Irene Hernández-Lozano, Oliver Langer & Nicolas Tournier. (2021) Repurposing 99m Tc-Mebrofenin as a Probe for Molecular Imaging of Hepatocyte Transporters . Journal of Nuclear Medicine 62:8, pages 1043-1047.
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Irene Hernández-Lozano, Thomas Wanek, Michael Sauberer, Thomas Filip, Severin Mairinger, Johann Stanek, Alexander Traxl, Rudolf Karch, John D. Schuetz & Oliver Langer. (2021) Influence of ABC transporters on the excretion of ciprofloxacin assessed with PET imaging in mice. European Journal of Pharmaceutical Sciences 163, pages 105854.
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Solène Marie, Irene Hernández-Lozano, Louise Breuil, Charles Truillet, Shuiying Hu, Alex Sparreboom, Nicolas Tournier & Oliver Langer. (2021) Imaging-Based Characterization of a Slco2b1(-/-) Mouse Model Using [11C]Erlotinib and [99mTc]Mebrofenin as Probe Substrates. Pharmaceutics 13:6, pages 918.
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Solène Marie, Irene Hernández-Lozano, Louise Breuil, Wadad Saba, Anthony Novell, Jean-Luc Gennisson, Oliver Langer, Charles Truillet & Nicolas Tournier. (2020) Validation of Pharmacological Protocols for Targeted Inhibition of Canalicular MRP2 Activity in Hepatocytes Using [99mTc]mebrofenin Imaging in Rats. Pharmaceutics 12:6, pages 486.
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Flavia Storelli, Mengyue Yin, Aditya R. Kumar, Mayur K. Ladumor, Raymond Evers, Paresh P. Chothe, Osatohanmwen J. Enogieru, Xiaomin Liang, Yurong Lai & Jashvant D. Unadkat. (2022) The Next Frontier in ADME Science: Predicting Transporter-Based Drug Disposition, Tissue Concentrations and Drug-Drug Interactions in Humans. SSRN Electronic Journal.
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Use of imaging to assess the activity of hepatic transporters

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