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Expert Opinion on Drug Metabolism & Toxicology Volume 16, 2020 - Issue 3
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Review

Recent advances in understanding the hepatotoxicity associated with protein kinase inhibitors

Qiang ShiDivision of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USACorrespondence[email protected]
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,
Xi YangDivision of Cardiovascular and Renal Products, Office of New Drugs I, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USAView further author information
,
Lijun RenDivision of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USAView further author information
&
William B. MattesDivision of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USAView further author information
Pages 217-226 | Received 19 Nov 2019, Accepted 06 Feb 2020, Published online: 12 Feb 2020

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Miao Yan, Wenqun Li, Wen-Bo Li, Qi Huang, Jing Li, Hua-Lin Cai, Hui Gong, Bi-Kui Zhang & Yi-Kun Wang. (2023) Metabolic activation of tyrosine kinase inhibitors: recent advance and further clinical practice. Drug Metabolism Reviews 55:1-2, pages 94-106.
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Jiangxia Du, Hao Yan, Zhifei Xu, Bo Yang, Qiaojun He, Xiaohong Wang & Peihua Luo. (2021) Cutaneous toxicity of FDA-approved small-molecule kinase inhibitors. Expert Opinion on Drug Metabolism & Toxicology 17:11, pages 1311-1325.
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Haochen Jiang, Ying Jin, Hao Yan, Zhifei Xu, Bo Yang, Qiaojun He & Peihua Luo. (2021) Hepatotoxicity of FDA-approved small molecule kinase inhibitors. Expert Opinion on Drug Safety 20:3, pages 335-348.
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Articles from other publishers (8)

Tugce Boran, Ozge Sultan Zengin, Zehra Seker, Aysenur Gunaydin Akyildiz, Ezgi Oztas & Gül Özhan. (2024) The cyclin-dependent kinase inhibitor abemaciclib-induced hepatotoxicity: Insight on the molecular mechanisms in HepG2/THP-1 co-culture model. Toxicology Letters 391, pages 1-12.
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Paige H. Parrack, Stephen D. Zucker & Lei Zhao. (2023) Liver Pathology Related to Onco-Therapeutic Agents. Surgical Pathology Clinics 16:3, pages 499-518.
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Alf Claesson & Kevin Parkes. (2022) Non-innocuous Consequences of Metabolic Oxidation of Alkyls on Arenes. Journal of Medicinal Chemistry 65:17, pages 11433-11453.
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Manuel Ramos-Casals, Alejandra Flores-Chávez, Pilar Brito-Zerón, Olivier Lambotte & Xavier Mariette. (2022) Immune-related adverse events of cancer immunotherapies targeting kinases. Pharmacology & Therapeutics 237, pages 108250.
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Shaoxing Guan, Xi Chen, Youhao Chen, Guohui Wan, Qibiao Su, Heng Liang, Yunpeng Yang, Wenfeng Fang, Yan Huang, Hongyun Zhao, Wei Zhuang, Shu Liu, Fei Wang, Wei Feng, Xiaoxu Zhang, Min Huang, Xueding Wang & Li Zhang. (2022) FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy. Acta Pharmaceutica Sinica B 12:9, pages 3639-3649.
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Huiqun Dong, Jia You, Yu Zhao, Danhua Zheng, Yi Zhong, Gaozheng Li, Zuquan Weng, Heng Luo & Shan Jiang. (2022) Study on the Characteristics of Small-Molecule Kinase Inhibitors-Related Drug-Induced Liver Injury. Frontiers in Pharmacology 13.
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Lin Guo, Tingli Tang, Dongmei Fang, Hui Gong, Bikui Zhang, Yueyin Zhou, Leiyi Zhang & Miao Yan. (2022) An Insight on the Pathways Involved in Crizotinib and Sunitinib Induced Hepatotoxicity in HepG2 Cells and Animal Model. Frontiers in Oncology 12.
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Moran Grossman & Elaine Adler. 2021. Protein Kinases - Promising Targets for Anticancer Drug Research. Protein Kinases - Promising Targets for Anticancer Drug Research.

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