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Expert Opinion on Drug Metabolism & Toxicology Volume 16, 2020 - Issue 8
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EDITORIAL

Soft drugs: design principles, success stories, and future perspectives

Peter BuchwaldDiabetes Research Institute and Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2732-8180View further author information
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Pages 645-650 | Received 08 Apr 2020, Accepted 28 May 2020, Published online: 20 Jun 2020

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Hygor M. R. de Souza, Jéssica S. Guedes, Rosana H. C. N. Freitas, Luis G. V. Gelves, Harold H. Fokoue, Carlos Mauricio R. Sant’Anna, Eliezer J. Barreiro & Lidia M. Lima. (2022) Comparative chemical and biological hydrolytic stability of homologous esters and isosteres. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 718-727.
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Seetharaman Balaji. (2023) Metabophore-mediated retro-metabolic (‘MeMeReMe’) approach in drug design. Drug Discovery Today 28:10, pages 103736.
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Patrick Jay B. Garcia, Steven Kuan-Hua Huang, Kathlia A. De Castro-Cruz, Rhoda B. Leron & Po-Wei Tsai. (2023) In Silico Neuroprotective Effects of Specific Rheum palmatum Metabolites on Parkinson’s Disease Targets. International Journal of Molecular Sciences 24:18, pages 13929.
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Piermichele Kobauri, Frank J. Dekker, Wiktor Szymanski & Ben L. Feringa. (2023) Rational Design in Photopharmacology with Molecular Photoswitches. Angewandte Chemie International Edition 62:30.
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Piermichele Kobauri, Frank J. Dekker, Wiktor Szymanski & Ben L. Feringa. (2023) Rational Design in Photopharmacology with Molecular Photoswitches. Angewandte Chemie 135:30.
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Gebhard Thoma, Eric Vangrevelinghe, Alexandre Luneau, Philippe Piechon, Christian Beerli & Hans-Guenter Zerwes. (2023) Novel Concept for Super-Soft Topical Drugs: Deactivation by an Enzyme-Induced Switch into an Inactive Conformation. ACS Medicinal Chemistry Letters 14:6, pages 841-845.
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Ruth Dorel, Alice R. Wong & James J. Crawford. (2023) Trust Your Gut: Strategies and Tactics for Intestinally Restricted Drugs. ACS Medicinal Chemistry Letters 14:3, pages 233-243.
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Yu-Bo Fang, Cheng-Yu Wang, Yu-Qing Gao, Yu-Hang Cai, Jia Chen, Xu-Lin Zhang, Le-Qi Dong, Wang-Ning Shang-Guan & Hua-Cheng Liu. (2023) The safety and efficacy of remimazolam tosylate for induction and maintenance of general anesthesia in pediatric patients undergoing elective surgery: Study protocol for a multicenter, randomized, single-blind, positive-controlled clinical trial. Frontiers in Pharmacology 14.
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Paul W. R. Harris, Andrew Siow, Sung-Hyun Yang, Andrew D. Wadsworth, Lyndia Tan, Yann Hermant, Yubing Mao, Chalice An, Cameron C. Hanna, Alan J. Cameron, Jane R. Allison, Aparajita Chakraborty, Scott A. Ferguson, Sonya Mros, Kiel Hards, Gregory M. Cook, Deborah A. Williamson, Glen P. Carter, Susanna T. S. Chan, Gavin A. Painter, Veronika Sander, Alan J. Davidson & Margaret A. Brimble. (2022) Synthesis, Antibacterial Activity, and Nephrotoxicity of Polymyxin B Analogues Modified at Leu-7, d -Phe-6, and the N-Terminus Enabled by S-Lipidation . ACS Infectious Diseases 8:12, pages 2413-2429.
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Asia Fernández-Carvajal, Gregorio Fernández-Ballester & Antonio Ferrer-Montiel. (2022) TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy. Frontiers in Molecular Neuroscience 15.
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Chaoyi Deng, Jin Liu & Wensheng Zhang. (2022) Structural Modification in Anesthetic Drug Development for Prodrugs and Soft Drugs. Frontiers in Pharmacology 13.
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Ming-Shu Wang, Yi Gong, Lin-Sheng Zhuo, Xing-Xing Shi, Yan-Guang Tian, Chang-Kang Huang, Wei Huang & Guang-Fu Yang. (2022) Distribution- and Metabolism-Based Drug Discovery: A Potassium-Competitive Acid Blocker as a Proof of Concept. Research 2022.
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Jiamin Zheng, Jun Wu, Xiao Ding, Hong C. Shen & Ge Zou. (2021) Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 38, pages 127862.
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