507
Views
14
CrossRef citations to date
0
Altmetric
Review

PXR-mediated idiosyncratic drug-induced liver injury: mechanistic insights and targeting approaches

, , &
Pages 711-722 | Received 09 May 2020, Accepted 04 Jun 2020, Published online: 16 Jun 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Ning Wang, Shaochen Guo, Haiting Liu, Yangming Ding, Rong Yao, Zhongquan Liu, Hui Zhu, Xi Chen, Xinting Yang, Xiaoyou Chen & Yu Lu. (2022) Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity. Xenobiotica 52:5, pages 520-526.
Read now
Emanuel Raschi, Paolo Caraceni, Elisabetta Poluzzi & Fabrizio De Ponti. (2020) Baricitinib, JAK inhibitors and liver injury: a cause for concern in COVID-19?. Expert Opinion on Drug Safety 19:10, pages 1367-1369.
Read now

Articles from other publishers (12)

Andrew D. Huber, Shyaron Poudel, Yongtao Li, Wenwei Lin, Jing Wu, Darcie J. Miller & Taosheng Chen. (2023) Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand. Structure 31:12, pages 1545-1555.e9.
Crossref
Rebecca R. Florke Gee, Andrew D. Huber, Jing Wu, Richa Bajpai, Allister J. Loughran, Shondra M. Pruett-Miller & Taosheng Chen. (2023) The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation. Acta Pharmaceutica Sinica B 13:11, pages 4523-4534.
Crossref
Yuan Liang, Yiyao Gong, Qiuyan Jiang, Yifan Yu & Jie Zhang. (2023) Environmental endocrine disruptors and pregnane X receptor action: A review. Food and Chemical Toxicology 179, pages 113976.
Crossref
Zdeněk Dvořák, Hao Li & Sridhar Mani. (2023) Microbial Metabolites as Ligands to Xenobiotic Receptors: Chemical Mimicry as Potential Drugs of the Future. Drug Metabolism and Disposition 51:2, pages 219-227.
Crossref
Xiuping Zhuang, Li Li, Tianyi Liu, Rui Zhang, Peimin Yang, Xin Wang & Long Dai. (2022) Mechanisms of isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review. Frontiers in Pharmacology 13.
Crossref
Cai Zhang, Jin-Quan Zhao, Jia-Xing Sun & Hui-Jun Li. (2022) Psoralen and isopsoralen from Psoraleae Fructus aroused hepatotoxicity via induction of aryl hydrocarbon receptor-mediated CYP1A2 expression. Journal of Ethnopharmacology 297, pages 115577.
Crossref
Jingjing Huang, Zhaokang Zhang, Chenxia Hao, Yuzhen Qiu, Ruoming Tan, Jialin Liu, Xiaoli Wang, Wanhua Yang & Hongping Qu. (2022) Identifying Drug-Induced Liver Injury Associated With Inflammation-Drug and Drug-Drug Interactions in Pharmacologic Treatments for COVID-19 by Bioinformatics and System Biology Analyses: The Role of Pregnane X Receptor. Frontiers in Pharmacology 13.
Crossref
Meiling Zhang, Jia Zhu, Nannan Wang, Wenpei Liu, Lihuan Lu, Hongqiu Pan, Xiaomin He, Honggang Yi & Shaowen Tang. (2022) The role of the genetic variant FECH rs11660001 in the occurrence of anti‐tuberculosis drug‐induced liver injury . Journal of Clinical Pharmacy and Therapeutics 47:8, pages 1276-1283.
Crossref
Mei Li, Ziyong Xu, Wang Lu, Liping Wang & Yujuan Zhang. (2022) Potential Pharmacokinetic Effect of Chicken Xenobiotic Receptor Activator on Sulfadiazine: Involvement of P-glycoprotein Induction. Antibiotics 11:8, pages 1005.
Crossref
Youhao Chen, Shaoxing Guan, Yanping Guan, Siyuan Tang, Yanying Zhou, Xueding Wang, Huichang Bi & Min Huang. (2022) Novel Clinical Biomarkers for Drug-Induced Liver Injury. Drug Metabolism and Disposition 50:5, pages 671-684.
Crossref
Yuqing Wu, Guangming Xiao, Peilan Zong, Guoqiang Jiang, Yongmei Liao, Zhou Liu & Yanhong Zhou. (2021) Diagnosis of Hypersensitivity Induced by Antituberculosis Drugs. Journal of Healthcare Engineering 2021, pages 1-5.
Crossref
Antonio Segovia-Zafra, Daniel E. Di Zeo-Sánchez, Carlos López-Gómez, Zeus Pérez-Valdés, Eduardo García-Fuentes, Raúl J. Andrade, M. Isabel Lucena & Marina Villanueva-Paz. (2021) Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction. Acta Pharmaceutica Sinica B 11:12, pages 3685-3726.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.