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Expert Opinion on Drug Metabolism & Toxicology Volume 16, 2020 - Issue 8
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Review

New clinical targets of d-chiro-inositol: rationale and potential applications

Antonio Simone Laganàa Department of Obstetrics and Gynecology, “Filippo Del Ponte” Hospital, University of Insubria, Varese, Italy;b The Experts Group on Inositol in Basic and Clinical Research (EGOI): https://www.inositolgroup.comCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1543-2802View further author information
ORCID Icon,
Simone Garzona Department of Obstetrics and Gynecology, “Filippo Del Ponte” Hospital, University of Insubria, Varese, ItalyORCID Iconhttps://orcid.org/0000-0002-5840-699XView further author information
ORCID Icon &
Vittorio Unferb The Experts Group on Inositol in Basic and Clinical Research (EGOI): https://www.inositolgroup.com;c Systems Biology Group Lab, “Sapienza” University, Piazza Biroldi 1, 21100 Varese, ItalyORCID Iconhttps://orcid.org/0000-0002-1805-3181View further author information
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Pages 703-710 | Received 04 Apr 2020, Accepted 17 Jun 2020, Published online: 09 Jul 2020

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Antonio Cianci & Salvatore Giovanni Vitale. (2022) D-Chiro-inositol and PCOS: between myth and reality. The never-ending story. International Journal of Food Sciences and Nutrition 73:5, pages 565-570.
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Antonio Simone Laganà, Gianpiero Forte, Mariano Bizzarri, Zdravko A. Kamenov, Bianca Bianco, Cihan Kaya, Georgios Gitas, Ibrahim Alkatout, Milan Terzic & Vittorio Unfer. (2022) Inositols in the ovaries: activities and potential therapeutic applications. Expert Opinion on Drug Metabolism & Toxicology 18:2, pages 123-133.
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Articles from other publishers (11)

Giuseppina Porcaro, Gabriele Bilotta, Elena Capoccia, Maria Salomé Bezerra Espinola & Cesare Aragona. (2023) D-Chiro-Inositol in Endometrial Hyperplasia: A Pilot Study. International Journal of Molecular Sciences 24:12, pages 10080.
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Giuseppe Gullo, Gaspare Cucinella, Vito Chiantera, Miriam Dellino, Eliano Cascardi, Péter Török, Tünde Herman, Simone Garzon, Stefano Uccella & Antonio Simone Laganà. (2023) Fertility-Sparing Strategies for Early-Stage Endometrial Cancer: Stepping towards Precision Medicine Based on the Molecular Fingerprint. International Journal of Molecular Sciences 24:1, pages 811.
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Vittorio Unfer, Dinicola Simona, Radici Sara & Gerli Sandro. (2022) Adjuvant treatment with D-chiro-inositol: A possible therapeutic strategy for insulin resistant and obese women with endometrial hyperplasia?. Medical Hypotheses 164, pages 110860.
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Gulzhanat Aimagambetova, Sanja Terzic, Antonio Simone Laganà, Gauri Bapayeva, Philip la Fleur & Milan Terzic. (2021) Contemporary Fertility-Sparing Management Options of Early Stage Endometrioid Endometrial Cancer in Young Nulliparous Patients. Journal of Clinical Medicine 11:1, pages 196.
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Giovanni Monastra, Mónica Vazquez-Levin, Maria Salome Bezerra Espinola, Gabriele Bilotta, Antonio Simone Laganà & Vittorio Unfer. (2021) D-chiro-inositol, an aromatase down-modulator, increases androgens and reduces estrogens in male volunteers: a pilot study. Basic and Clinical Andrology 31:1.
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Simona Dinicola, Vittorio Unfer, Fabio Facchinetti, Christophe O. Soulage, Nicholas D. Greene, Mariano Bizzarri, Antonio Simone Laganà, Shiao-Yng Chan, Arturo Bevilacqua, Lali Pkhaladze, Salvatore Benvenga, Annarita Stringaro, Daniele Barbaro, Marialuisa Appetecchia, Cesare Aragona, Maria Salomè Bezerra Espinola, Tonino Cantelmi, Pietro Cavalli, Tony T. Chiu, Andrew J. Copp, Rosario D’Anna, Didier Dewailly, Cherubino Di Lorenzo, Evanthia Diamanti-Kandarakis, Imelda Hernández Marín, Moshe Hod, Zdravko Kamenov, Eleni Kandaraki, Giovanni Monastra, Mario Montanino Oliva, John E. Nestler, Maurizio Nordio, Ali C. Ozay, Olga Papalou, Giuseppina Porcaro, Nikos Prapas, Scott Roseff, Monica Vazquez-Levin, Ivana Vucenik & Artur Wdowiak. (2021) Inositols: From Established Knowledge to Novel Approaches. International Journal of Molecular Sciences 22:19, pages 10575.
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Maria Nunzia De Luca, Marisa Colone, Riccardo Gambioli, Annarita Stringaro & Vittorio Unfer. (2021) Oxidative Stress and Male Fertility: Role of Antioxidants and Inositols. Antioxidants 10:8, pages 1283.
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Feier Cheng, Shao-jun Yun, Jin-ling Cao, Ming-chang Chang, Jun-long Meng, Jing-yu Liu, Yan-fen Cheng & Cui-ping Feng. (2021) Differential Gene Expression and Biological Analyses of Primary Hepatocytes Following D-Chiro-Inositol Supplement. Frontiers in Endocrinology 12.
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Giovanni Monastra, Ivana Vucenik, Abdel Halim Harrath, Saleh H. Alwasel, Zdravko A. Kamenov, Antonio Simone Laganà, Noemi Monti, Valeria Fedeli & Mariano Bizzarri. (2021) PCOS and Inositols: Controversial Results and Necessary Clarifications. Basic Differences Between D-Chiro and Myo-Inositol. Frontiers in Endocrinology 12.
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Jie Zhou, Yong Tan, Xudong Wang & Meihong Zhu. (2021) Paeoniflorin attenuates DHEA-induced polycystic ovary syndrome via inactivation of TGF-β1/Smads signaling pathway in vivo. Aging 13:5, pages 7084-7095.
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Agnese Filippello, Alessandra Scamporrino, Stefania Di Mauro, Roberta Malaguarnera, Antonino Di Pino, Roberto Scicali, Francesco Purrello & Salvatore Piro. (2020) Direct Effects of D-Chiro-Inositol on Insulin Signaling and Glucagon Secretion of Pancreatic Alpha Cells. Biomolecules 10:10, pages 1404.
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