Advanced search
Publication Cover
Expert Opinion on Drug Metabolism & Toxicology Volume 17, 2021 - Issue 3
Submit an article Journal homepage
2,049
Views
55
CrossRef citations to date
0
Altmetric
Review

The role of non-coding RNAs in ABC transporters regulation and their clinical implications of multidrug resistance in cancer

Yu WangInstitution of Drug Metabolism and Pharmaceutical Analysis, Cancer Center of Zhejiang University,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaView further author information
,
Yingying WangInstitution of Drug Metabolism and Pharmaceutical Analysis, Cancer Center of Zhejiang University,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaView further author information
,
Zhiyuan QinInstitution of Drug Metabolism and Pharmaceutical Analysis, Cancer Center of Zhejiang University,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaORCID Iconhttps://orcid.org/0000-0003-0824-5638View further author information
ORCID Icon,
Sheng CaiInstitution of Drug Metabolism and Pharmaceutical Analysis, Cancer Center of Zhejiang University,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaView further author information
,
Lushan YuInstitution of Drug Metabolism and Pharmaceutical Analysis, Cancer Center of Zhejiang University,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaView further author information
,
Haihong HuInstitution of Drug Metabolism and Pharmaceutical Analysis, Cancer Center of Zhejiang University,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaCorrespondence[email protected]
View further author information
&
Su ZengInstitution of Drug Metabolism and Pharmaceutical Analysis, Cancer Center of Zhejiang University,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaView further author information
 show all
Pages 291-306 | Received 23 Nov 2020, Accepted 04 Feb 2021, Published online: 22 Feb 2021

Citations (55)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Yunchun Zhao, Shuya Ye, Yao Zhu, Yue Chen, Shan Yang, Fengmei Wang, Rong Wang, Dongxu Qin, Dongli Sun & Caihong Zheng. (2023) Advancement in transporter-oriented nanoplatforms for cancer therapy. Journal of Drug Targeting 31:5, pages 456-470.
Read now
Dongdong Xue, Jingzhao Han, Ze Liang, Lin Jia, Yifan Liu, Hongfang Tuo & Yanhui Peng. (2022) Current Perspectives on the Unique Roles of Exosomes in Drug Resistance of Hepatocellular Carcinoma. Journal of Hepatocellular Carcinoma 9, pages 99-112.
Read now
Qilai Cheng, Shanshan Zhang, Bing Zhong, Zhixi Chen & Fang Peng. (2022) Asiatic acid re-sensitizes multidrug-resistant A549/DDP cells to cisplatin by down regulating long non-coding RNA metastasis associated lung adenocarcinoma transcript 1/β-catenin signaling. Bioengineered 13:5, pages 12972-12984.
Read now

Articles from other publishers (52)

Yong-Qiang Ao, Jian Gao, Jia-Hao Jiang, Hai-Kun Wang, Shuai Wang & Jian-Yong Ding. (2023) Comprehensive landscape and future perspective of long noncoding RNAs in non-small cell lung cancer: it takes a village. Molecular Therapy 31:12, pages 3389-3413.
Crossref
Jiangjun Cao, Zhe Zhang, Li Zhou, Maochao Luo, Lei Li, Bowen Li, Edouard C. Nice, Weifeng He, Shaojiang Zheng & Canhua Huang. (2023) Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy. MedComm 4:6.
Crossref
Yaomin Luo, Xintong Lu, Wenrong Ma, Yang Xiao, Chen Wei, Xiaoxia Yuan, Yueyue Wu, Yunlin Wang, Yiman Xiong, Xin Yu, Xue Wu, Siqi He, Yayudie Liu, Jinjing Wang, Qing Wu, Hui Zhou & Zhen Jiang. (2023) Dampening HOTAIR sensitizes the gastric cancer cells to oxaliplatin through miR ‐195‐5p and ABCG2 pathway . Journal of Cellular and Molecular Medicine 27:22, pages 3591-3600.
Crossref
Andaleeb Sajid, Hadiar Rahman & Suresh V. Ambudkar. (2023) Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters. Nature Reviews Cancer 23:11, pages 762-779.
Crossref
Fanbo Jing, Xiao Li, Hui Jiang, Jialin Sun & Qie Guo. (2023) Combating drug resistance in hepatocellular carcinoma: No awareness today, no action tomorrow. Biomedicine & Pharmacotherapy 167, pages 115561.
Crossref
Changqing Liu, Shan Li & Yunlian Tang. (2023) Mechanism of cisplatin resistance in gastric cancer and associated microRNAs. Cancer Chemotherapy and Pharmacology 92:5, pages 329-340.
Crossref
Bihan Xia, Yuzhi Liu, Jin Wang, Qing Lu, Xiuhe Lv, Kai Deng & Jinlin Yang. (2023) Emerging role of exosome-shuttled noncoding RNAs in gastrointestinal cancers: From intercellular crosstalk to clinical utility. Pharmacological Research 195, pages 106880.
Crossref
Hamdoon A. Mohammed, Muhamad Abd-Elraouf, Ghassan M Sulaiman, Suliman A. Almahmoud, Fatma A. Hamada, Riaz A. Khan, Mostafa M. Hegazy, Mohammed F. Abd-El-Wahab, Taha A Kedra & Ahmed Ismail. (2023) Variability in the volatile constituents and biological activities of Achillea millefolium L. essential oils obtained from different plant parts and by different solvents. Arabian Journal of Chemistry 16:9, pages 105103.
Crossref
Jiamin Jin, Jiacheng Cong, Shangbo Lei, Qiujin Zhang, Xinyi Zhong, Yingying Su, Mingchuan Lu, Yifen Ma, Zihe Li, Liyan Wang, Ningxia Zhu & Jinfeng Yang. (2023) Cracking the code: Deciphering the role of the tumor microenvironment in osteosarcoma metastasis. International Immunopharmacology 121, pages 110422.
Crossref
Sayedeh Azimeh Hosseini, Mohammad Hossein Haddadi, Hadis Fathizadeh, Foroogh Nemati, Hooman Mahmoudi Aznaveh, Farima Taraj, AmirArsalan Aghabozorgizadeh, Golmaryam Gandomkar & Elaheh Bazazzadeh. (2023) Long non-coding RNAs and gastric cancer: An update of potential biomarkers and therapeutic applications. Biomedicine & Pharmacotherapy 163, pages 114407.
Crossref
Xiaobin Chi, Zhijian Chen, Yongbiao Chen, Hanyin Hong, Jianda Yu & Lizhi Lv. (2023) Upregulation of lncRNA PTOV1‐AS1 in hepatocellular carcinoma contributes to disease progression and sorafenib resistance through regulating miR‐505. Journal of Biochemical and Molecular Toxicology.
Crossref
Yuan Fang, XiaoLi Zhang, HanFei Huang & Zhong Zeng. (2023) The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little things. Journal of Translational Medicine 21:1.
Crossref
Zi‐Ning Lei, Qin Tian, Qiu‐Xu Teng, John N. D. Wurpel, Leli Zeng, Yihang Pan & Zhe‐Sheng Chen. (2023) Understanding and targeting resistance mechanisms in cancer. MedComm 4:3.
Crossref
Manasi S. Pote & Rajesh N. Gacche. (2023) ATP-binding cassette efflux transporters and MDR in cancer. Drug Discovery Today 28:5, pages 103537.
Crossref
Shulong Shi, Sihao Zhao, Xinchen Tian, Fen Liu, Xiulian Lu, Hengchang Zang, Feng Li, Longquan Xiang, Luning Li & Shulong Jiang. (2023) Molecular and metabolic mechanisms of bufalin against lung adenocarcinoma: New and comprehensive evidences from network pharmacology, metabolomics and molecular biology experiment. Computers in Biology and Medicine 157, pages 106777.
Crossref
Homeyra Seydi, Kosar Nouri, Niloufar Rezaei, Atena Tamimi, Moustapha Hassan, Hamed Mirzaei & Massoud Vosough. (2023) Autophagy orchestrates resistance in hepatocellular carcinoma cells. Biomedicine & Pharmacotherapy 161, pages 114487.
Crossref
Emine Bayraktar, Recep Bayraktar, Hulya Oztatlici, Gabriel Lopez-Berestein, Paola Amero & Cristian Rodriguez-Aguayo. (2023) Targeting miRNAs and Other Non-Coding RNAs as a Therapeutic Approach: An Update. Non-Coding RNA 9:2, pages 27.
Crossref
Yeqin Fu, Qiuhui Yang, Hongjian Yang & Xiping Zhang. (2023) New progress in the role of microRNAs in the diagnosis and prognosis of triple negative breast cancer. Frontiers in Molecular Biosciences 10.
Crossref
Mikhail G. Dozmorov, Maggie A. Marshall, Narmeen S. Rashid, Jacqueline M. Grible, Aaron Valentine, Amy L. Olex, Kavita Murthy, Abhijit Chakraborty, Joaquin Reyna, Daniela Salgado Figueroa, Laura Hinojosa-Gonzalez, Erika Da-Inn Lee, Brittany A. Baur, Sushmita Roy, Ferhat Ay & J. Chuck Harrell. (2023) Rewiring of the 3D genome during acquisition of carboplatin resistance in a triple-negative breast cancer patient-derived xenograft. Scientific Reports 13:1.
Crossref
Po-Shuan Huang, Ling-Yu Wang, Yi-Wen Wang, Ming-Ming Tsai, Tzu-Kang Lin, Chia-Jung Liao, Chau-Ting Yeh & Kwang-Huei Lin. (2023) Evaluation and Application of Drug Resistance by Biomarkers in the Clinical Treatment of Liver Cancer. Cells 12:6, pages 869.
Crossref
Mei-Juan Tu & Ai-Ming Yu. (2023) Recent Advances in Novel Recombinant RNAs for Studying Post-transcriptional Gene Regulation in Drug Metabolism and Disposition. Current Drug Metabolism 24:3, pages 175-189.
Crossref
Quanjin Zhang, Feng Ding, Congcong Zhang, Xu Han & Hui Cheng. (2023) Circ_0001715 Functions as a miR-1249-3p Sponge to Accelerate the Progression of Non-small Cell Lung Cancer via Upregulating the Level of FGF5. Biochemical Genetics.
Crossref
Zimin Li, Junzheng Zheng, Jian Xu & Quan Niu. (2022) Knockdown of Circ_0000798 Impedes Cell Growth and Motility of Renal Cell Carcinoma Cells Through Functioning as miRNA Sponge for miR-589-5p. Biochemical Genetics 61:1, pages 279-298.
Crossref
Yang Liu, Xia Xiao, Jingying Wang, Yitong Wang & Yanhui Yu. (2022) Silencing CircEIF3I/miR-526b-5p Axis Epigenetically Targets HGF/c-Met Signal to Hinder the Malignant Growth, Metastasis and Angiogenesis of Hepatocellular Carcinoma. Biochemical Genetics 61:1, pages 48-68.
Crossref
Yun Lv, Xiaobo Du, Wenqiang Tang, Qian Yang & Feng Gao. (2023) Exosomes: The Role in Tumor Tolerance and the Potential Strategy for Tumor Therapy. Pharmaceutics 15:2, pages 462.
Crossref
Mona Sheta, Eman A. Taha, Yanyin Lu & Takanori Eguchi. (2023) Extracellular Vesicles: New Classification and Tumor Immunosuppression. Biology 12:1, pages 110.
Crossref
Maria Pia Adorni, Maricla Galetti, Silvia La Monica, Matteo Incerti, Alessandro Ruffoni, Lisa Elviri, Ilaria Zanotti, Bianca Papotti, Delia Cavallo, Roberta Alfieri, Pier Giorgio Petronini & Franco Bernini. (2023) A New ABCB1 Inhibitor Enhances the Anticancer Effect of Doxorubicin in Both In Vitro and In Vivo Models of NSCLC. International Journal of Molecular Sciences 24:2, pages 989.
Crossref
Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Pragya Bradu, Aarthi Sukumar, Megha Patil, Kaviyarasi Renu, Abhijit Dey, Balachandar Vellingiri, Alex George & Raja Ganesan. (2023) Implications of cancer stem cells in diabetes and pancreatic cancer. Life Sciences 312, pages 121211.
Crossref
Nicholas R. Powell, Rebecca M. Silvola, John S. Howard, Sunil Badve, Todd C. Skaar & Joseph Ipe. (2022) Quantification of spatial pharmacogene expression heterogeneity in breast tumors. Cancer Reports 6:1.
Crossref
YINGYING WANG, YING ZHOU, YU WANG, LUSHAN YU & SU ZENG. 2022. Drug Metabolism Handbook. Drug Metabolism Handbook 573 603 .
Jinhui Guo, Junjun Zhao, Qiuran Xu & Dongsheng Huang. (2022) Resistance of Lenvatinib in Hepatocellular Carcinoma. Current Cancer Drug Targets 22:11, pages 865-878.
Crossref
Shuang Qin, Yuting Wang, Peijun Wang & Qi Lv. (2022) Molecular mechanism of circRNAs in drug resistance in renal cell carcinoma. Cancer Cell International 22:1.
Crossref
Xiang Lin, Li Xu, Huicheng Tan, Xinyi Zhang, Huan Shao, Li Yao & Xuan Huang. (2022) The potential effects and mechanisms of Gegen Qinlian Decoction in oxaliplatin-resistant colorectal cancer based on network pharmacology. Heliyon 8:11, pages e11305.
Crossref
Cheng-Zhi Huang, Yue Zhou, Qi-Song Tong, Qi-Jia Duan, Qing Zhang, Jin-Zhi Du & Xue-Qing Yao. (2022) Precision medicine-guided co-delivery of ASPN siRNA and oxaliplatin by nanoparticles to overcome chemoresistance of colorectal cancer. Biomaterials 290, pages 121827.
Crossref
Jing Li, Xiao Li & Qie Guo. (2022) Drug Resistance in Cancers: A Free Pass for Bullying. Cells 11:21, pages 3383.
Crossref
Mahnaz Hashemi & Masoud Golalipour. (2022) ABCC6P1 pseudogene induces ABCC6 upregulation and multidrug resistance in breast cancer. Molecular Biology Reports 49:10, pages 9633-9639.
Crossref
Yixin Yin, Siqi Li, Xinqiang Liang, Kezhi Li, Mingzhi Xie & Bangli Hu. (2022) Construction and Validation of an Oxaliplatin-Resistant Gene Signature in Colorectal Cancer Patients Who Underwent Chemotherapy. Pharmaceuticals 15:9, pages 1139.
Crossref
Sethu Parvathy Pillai Babu, Sivaramakrishnan Venkatabalasubramanian, Sharathkumar R. Munisankar & Anand Thiyagaraj. (2022) Cancer stem cell markers interplay with chemoresistance in triple negative breast cancer: A therapeutic perspective. Bulletin du Cancer 109:9, pages 960-971.
Crossref
Tongkuo Yuan, Jia Hu, Xiaoming Zhu, Huancai Yin & Jian Yin. (2022) Oxidative stress‐mediated up‐regulation of ABC transporters in lung cancer cells. Journal of Biochemical and Molecular Toxicology 36:8.
Crossref
Wei Meng, Yanli Li, Binshu Chai, Xiaomin Liu & Zhongliang Ma. (2022) miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer. International Journal of Molecular Sciences 23:15, pages 8518.
Crossref
Zhimin Xu, Yingxin Zhang, Huanyan Dai & Bing Han. (2022) Epithelial–Mesenchymal Transition-Mediated Tumor Therapeutic Resistance. Molecules 27:15, pages 4750.
Crossref
Wei Peng, Wei Tang, Jian-Di Li, Rong-Quan He, Jia-Yuan Luo, Zu-Xuan Chen, Jiang-Hui Zeng, Xiao-Hua Hu, Jin-Cai Zhong, Yang Li, Fu-Chao Ma, Tian-Yi Xie, Su-Ning Huang & Lian-Ying Ge. (2022) Downregulation of the enhancer of zeste homolog 1 transcriptional factor predicts poor prognosis of triple-negative breast cancer patients. PeerJ 10, pages e13708.
Crossref
Chengpeng Sang, Dingyu Rao, Caixia Wu, Yao Xia, Maoyan Si & Zhixian Tang. (2022) Role of circular RNAs in the diagnosis, regulation of drug resistance and prognosis of lung cancer (Review). Oncology Letters 24:3.
Crossref
Liangyun Li, Yihui Bi, Shaoxi Diao, Xiaofeng Li, Tong Yuan, Tao Xu, Cheng Huang & Jun Li. (2022) Exosomal LncRNAs and hepatocellular Carcinoma: From basic research to clinical practice. Biochemical Pharmacology 200, pages 115032.
Crossref
Jianyou Gu, Wenjie Huang, Xianxing Wang, Junfeng Zhang, Tian Tao, Yao Zheng, Songsong Liu, Jiali Yang, Zhe-Sheng Chen, Chao-Yun Cai, Jinsui Li, Huaizhi Wang & Yingfang Fan. (2022) Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer. Molecular Cancer 21:1.
Crossref
Lingyan Ding, Lizhi Li & Zhaohui Tang. (2022) Cisplatin resistance and malignant behaviors of lung cancer cells are promoted by circ_0002360 via targeting miR ‐6751‐3p to regulate the expression of ZNF300 . Thoracic Cancer 13:7, pages 986-996.
Crossref
Yue Zhou, Qing Zhang, Minjia Wang, Chengzhi Huang & Xueqing Yao. (2022) Effective Delivery of siRNA-Loaded Nanoparticles for Overcoming Oxaliplatin Resistance in Colorectal Cancer. Frontiers in Oncology 12.
Crossref
Sepideh Mirzaei, Mohammad Hossein Gholami, Farid Hashemi, Amirhossein Zabolian, Mahdi Vasheghani Farahani, Kiavash Hushmandi, Ali Zarrabi, Aaron Goldman, Milad Ashrafizadeh & Gorka Orive. (2022) Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects. Drug Discovery Today 27:2, pages 436-455.
Crossref
Jinjin Chu, Xianzhu Fang, Zhonghou Sun, Linlin Gai, Wenqing Dai, Haibo Li, Xinyi Yan, Jinke Du, Lili Zhang, Lu Zhao, Donghua Xu & Shushan Yan. (2022) Non-Coding RNAs Regulate the Resistance to Anti-EGFR Therapy in Colorectal Cancer. Frontiers in Oncology 11.
Crossref
Po-Shuan Huang, Chia-Jung Liao, Ya-Hui Huang, Chau-Ting Yeh, Cheng-Yi Chen, Hui-Chi Tang, Cheng-Chih Chang & Kwang-Huei Lin. (2021) Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer. Cancers 13:21, pages 5361.
Crossref
Massimo Serra, Claudia Maria Hattinger, Michela Pasello, Chiara Casotti, Leonardo Fantoni, Chiara Riganti & Maria Cristina Manara. (2021) Impact of ABC Transporters in Osteosarcoma and Ewing’s Sarcoma: Which Are Involved in Chemoresistance and Which Are Not?. Cells 10:9, pages 2461.
Crossref
Haihong Hu, Yu Wang, Zhiyuan Qin, Wen Sun, Yanhong Chen, Jiaqi Wang, Yingying Wang, Jing Nie, Lu Chen, Sheng Cai, Lushan Yu & Su Zeng. (2021) Regulation of MRP4 Expression by circHIPK3 via Sponging miR-124-3p/miR-4524-5p in Hepatocellular Carcinoma. Biomedicines 9:5, pages 497.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.