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Study design

ALS trial design: expectation and reality

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Pages 52-54 | Published online: 10 Jul 2009

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Ruben PA van Eijk, Marinus JC Eijkemans, Dimitris Rizopoulos, Leonard H van den Berg & Stavros Nikolakopoulos. (2018) Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis. Clinical Epidemiology 10, pages 333-341.
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Robert Bowser, Merit Cudkowicz & Rima Kaddurah-Daouk. (2006) Biomarkers for amyotrophic lateral sclerosis. Expert Review of Molecular Diagnostics 6:3, pages 387-398.
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Mamede de Carvalho, João Costa & Michael Swash. (2005) Clinical trials in ALS: A review of the role of clinical and neurophysiological measurements. Amyotrophic Lateral Sclerosis 6:4, pages 202-212.
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Articles from other publishers (4)

Boudewijn T.H.M. Sleutjes, Ellen M. Maathuis, Pieter A. van Doorn, Joleen H. Blok & Gerhard H. Visser. (2016) Electrically evoked multiplet discharges are associated with more marked clinical deterioration in motor neuron disease. Muscle & Nerve 53:2, pages 222-226.
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Dan H Moore, Jonathan S Katz & Robert G Miller. (2011) A review of clinical trial designs in amyotrophic lateral sclerosis. Neurodegenerative Disease Management 1:6, pages 481-490.
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Paul H. Gordon, Bin Cheng, Francois Salachas, Pierre-Francois Pradat, Gaelle Bruneteau, Philippe Corcia, Lucette Lacomblez & Vincent Meininger. (2010) Progression in ALS is not linear but is curvilinear. Journal of Neurology 257:10, pages 1713-1717.
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Maria C.N. Marchetto, Alysson R. Muotri, Yangling Mu, Alan M. Smith, Gabriela G. Cezar & Fred H. Gage. (2008) Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells. Cell Stem Cell 3:6, pages 649-657.
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