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Surrogate markers

The Neurophysiological Index in ALS

Pages 108-110 | Published online: 10 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

. (2022) Theme 08 - Clinical Imaging and Electrophysiology. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 23:sup1, pages 125-132.
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So Young Pyun, Yerim Kim, Seong-Il Oh & Jong Seok Bae. (2020) Differences in nerve excitability properties between isolated bulbar palsy and bulbar-dominant amyotrophic lateral sclerosis. Neurological Research 42:2, pages 133-140.
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Julian Gold, Dominic B. Rowe, Matthew C. Kiernan, Steve Vucic, Susan Mathers, Ruben P. A. van Eijk, Avindra Nath, Marta Garcia Montojo, Gina Norato, Ulisses A. Santamaria, Mary-Louise Rogers, Andrea Malaspina, Vittoria Lombardi, Puja R. Mehta, Henk-Jan Westeneng, Leonard H. van den Berg & Ammar Al-Chalabi. (2019) Safety and tolerability of Triumeq in amyotrophic lateral sclerosis: the Lighthouse trial. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20:7-8, pages 595-604.
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Yu-ichi Noto, Kazumoto Shibuya, Steve Vucic & Matthew C. Kiernan. (2016) Novel therapies in development that inhibit motor neuron hyperexcitability in amyotrophic lateral sclerosis. Expert Review of Neurotherapeutics 16:10, pages 1147-1154.
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James R. Burrell, Steve Vucic & Matthew C. Kiernan. (2011) Isolated bulbar phenotype of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis 12:4, pages 283-289.
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Hua Wang, Kylyana S. Larriviere, Kristen E. Keller, Kathleen A. Ware, Ted M. Burns, Mark A. Conaway, David Lacomis, Gary L. Pattee, Lawrence H. Phillips$suffix/text()$suffix/text(), Nina J. Solenski, Sasa A. Zivkovic & James P. Bennett$suffix/text()$suffix/text(). (2008) R(+) pramipexole as a mitochondrially focused neuroprotectant: Initial early phase studies in ALS. Amyotrophic Lateral Sclerosis 9:1, pages 50-58.
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Articles from other publishers (41)

Roisin McMackin, Peter Bede, Caroline Ingre, Andrea Malaspina & Orla Hardiman. (2023) Biomarkers in amyotrophic lateral sclerosis: current status and future prospects. Nature Reviews Neurology 19:12, pages 754-768.
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Cláudia Santos Silva, Michael Swash & Mamede de Carvalho. (2023) Exploring the split hand phenomenon with the neurophysiological index. Neurophysiologie Clinique 53:4, pages 102864.
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Stefano Zoccolella, Alessia Giugno & Giancarlo Logroscino. (2023) Split phenomena in amyotrophic lateral sclerosis: Current evidences, pathogenetic hypotheses and diagnostic implications. Frontiers in Neuroscience 16.
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Vivek P. Chavda, Chirag Patel, Dharti Modh, Yavuz Nuri Ertas, Shreya S. Sonak, Nafesa K. Munshi, Krishnan Anand, Arun Soni & Sonal Pande. (2022) Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic. Current Drug Metabolism 23:3, pages 200-222.
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MariaN Zakharova & AnnaA Abramova. (2022) Lower and upper motor neuron involvement and their impact on disease prognosis in amyotrophic lateral sclerosis. Neural Regeneration Research 17:1, pages 65.
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Xuan Kang & Dianna Quan. (2021) Electrodiagnostic Assessment of Motor Neuron Disease. Neurologic Clinics 39:4, pages 1071-1081.
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Andrew Hannaford, Mana Higashihara, Nathan Pavey, Mehdi van den Bos, Nimeshan Geevasinga, Steve Vucic & Parvathi Menon. (2021) Split-hand index: A diagnostic and prognostic marker in amyotrophic lateral sclerosis across varying regions of onset. Clinical Neurophysiology 132:9, pages 2130-2135.
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Mehdi A. J. Bos, Mana Higashihara, Nimeshan Geevasinga, Parvathi Menon, Matthew C. Kiernan & Steve Vucic. (2020) Pathophysiological associations of transcallosal dysfunction in ALS. European Journal of Neurology 28:4, pages 1172-1180.
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Huiyan Yu, Lu Chen, Shuo Zhang, Jing He & Dongsheng Fan. (2021) Early Axonal Dysfunction of the Peripheral Nervous System Influences Disease Progression of ALS: Evidence From Clinical Neuroelectrophysiology. Frontiers in Neurology 12.
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Federico Ranieri, Sara Mariotto, Raffaele Dubbioso & Vincenzo Di Lazzaro. (2021) Brain Stimulation as a Therapeutic Tool in Amyotrophic Lateral Sclerosis: Current Status and Interaction With Mechanisms of Altered Cortical Excitability. Frontiers in Neurology 11.
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Liu-Qing Xu, Wei Hu, Qi-Fu Guo, Lu-Lu Lai, Guo-Rong Xu, Wan-Jin Chen, Ning Wang & Qi-Jie Zhang. (2020) Median Nerve-Neurophysiological Index Correlates With the Survival of Patients With Amyotrophic Lateral Sclerosis. Frontiers in Neurology 11.
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Mamede de Carvalho. (2020) Needling the future in ALS. Clinical Neurophysiology 131:8, pages 1973-1974.
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Mamede de Carvalho. (2020) Electrodiagnosis of Amyotrophic Lateral Sclerosis: A Review of Existing Guidelines. Journal of Clinical Neurophysiology 37:4, pages 294-298.
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Emel Oguz Akarsu, Nermin Gorkem Sirin, Elif Kocasoy Orhan, Bahar Erbas, Hava Ozlem Dede, Mehmet Baris Baslo, Halil Atilla Idrisoglu & Ali Emre Oge. (2020) Repeater F-waves in amyotrophic lateral sclerosis: Electrophysiologic indicators of upper or lower motor neuron involvement?. Clinical Neurophysiology 131:1, pages 96-105.
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Michael Swash & Mamede de Carvalho. (2019) The ‘neurophysiological index’ predicts survival in amyotrophic lateral sclerosis. Clinical Neurophysiology 130:9, pages 1684-1685.
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Bei Cao, Qianqian Wei, Ruwei Ou, Lingyu Zhang, Yanbing Hou, Yongping Chen & Huifang Shang. (2019) Neurophysiological index is associated with the survival of patients with amyotrophic lateral sclerosis. Clinical Neurophysiology 130:9, pages 1730-1733.
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David LacomisClifton Gooch. (2019) Upper motor neuron assessment and early diagnosis in ALS. Neurology 92:6, pages 255-256.
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William Huynh, Thanuja Dharmadasa, Steve Vucic & Matthew C. Kiernan. (2019) Functional Biomarkers for Amyotrophic Lateral Sclerosis. Frontiers in Neurology 9.
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Ileana M. Howard & Nassim Rad. (2018) Electrodiagnostic Testing for the Diagnosis and Management of Amyotrophic Lateral Sclerosis. Physical Medicine and Rehabilitation Clinics of North America 29:4, pages 669-680.
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Steve Vucic & Seward B. Rutkove. (2018) Neurophysiological biomarkers in amyotrophic lateral sclerosis. Current Opinion in Neurology 31:5, pages 640-647.
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Marcio Luiz Escorcio‐Bezerra, Agessandro Abrahao, Karlo Faria Nunes, Nadia Iandoli De Oliveira Braga, Acary Souza Bulle Oliveira, Lorne Zinman & Gilberto Mastrocola Manzano. (2018) Motor unit number index and neurophysiological index as candidate biomarkers of presymptomatic motor neuron loss in amyotrophic lateral sclerosis. Muscle & Nerve 58:2, pages 204-212.
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Kazumoto Shibuya, Neil G. Simon, Nimeshan Geevasinga, Parvathi Menon, James Howells, Susanna B. Park, William Huynh, Yu-ichi Noto, Steve Vucic & Matthew C. Kiernan. (2017) The evolution of motor cortical dysfunction in amyotrophic lateral sclerosis. Clinical Neurophysiology 128:6, pages 1075-1082.
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Kevin B. Boylan, Mark A. Ross & Eric J. Sorenson. 2017. Neurodegeneration. Neurodegeneration 137 160 .
Kazumoto Shibuya, Susanna B. Park, James Howells, William Huynh, Yu-ichi Noto, Nortina Shahrizaila, José M. Matamala, Steve Vucic & Matthew C. Kiernan. (2017) Laterality of motor cortical function measured by transcranial magnetic stimulation threshold tracking. Muscle & Nerve 55:3, pages 424-427.
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Robert D. Henderson & Pamela A. McCombe. (2016) Assessment of Motor Units in Neuromuscular Disease. Neurotherapeutics 14:1, pages 69-77.
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Jean-Pascal Lefaucheur & Mamede de Carvalho. (2016) New insights into the clinical neurophysiological assessment of ALS. Neurophysiologie Clinique/Clinical Neurophysiology 46:3, pages 157-163.
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Kazumoto Shibuya, Susanna B. Park, Nimeshan Geevasinga, William Huynh, Neil G. Simon, Parvathi Menon, James Howells, Steve Vucic & Matthew C. Kiernan. (2016) Threshold tracking transcranial magnetic stimulation: Effects of age and gender on motor cortical function. Clinical Neurophysiology 127:6, pages 2355-2361.
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Michael Benatar, Kevin Boylan, Andreas Jeromin, Seward B. Rutkove, James Berry, Nazem Atassi & Lucie Bruijn. (2016) ALS biomarkers for therapy development: State of the field and future directions. Muscle & Nerve 53:2, pages 169-182.
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Susanna B. Park, Steve Vucic, Benjamin C. Cheah, Cindy S.-Y. Lin, Adrienne Kirby, Kristy P. Mann, Margie C. Zoing, Jennica Winhammar & Matthew C. Kiernan. (2015) Flecainide in Amyotrophic Lateral Sclerosis as a Neuroprotective Strategy (FANS): A Randomized Placebo-Controlled Trial. EBioMedicine 2:12, pages 1916-1922.
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Atsuko Mori, Hiroyuki Nodera, Naoko Takamatsu, Yoshimitsu Shimatani, Keiko Maruyama, Masaya Oda, Yuishin Izumi & Ryuji Kaji. (2015) Focal nerve enlargement is not the cause for increased distal motor latency in ALS: Sonographic evaluation. Clinical Neurophysiology 126:8, pages 1632-1637.
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Seward B. Rutkove. (2015) Clinical Measures of Disease Progression in Amyotrophic Lateral Sclerosis. Neurotherapeutics 12:2, pages 384-393.
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Eric J. Sorenson. (2012) The Electrophysiology of the Motor Neuron Diseases. Neurologic Clinics 30:2, pages 605-620.
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Jeban Ganesalingam & Robert Bowser. (2010) The application of biomarkers in clinical trials for motor neuron disease. Biomarkers in Medicine 4:2, pages 281-297.
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Martin R Turner, Matthew C Kiernan, P Nigel Leigh & Kevin Talbot. (2009) Biomarkers in amyotrophic lateral sclerosis. The Lancet Neurology 8:1, pages 94-109.
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Per M. Roos, Olof Vesterberg & Monica Nordberg. (2016) Metals in Motor Neuron Diseases. Experimental Biology and Medicine 231:9, pages 1481-1487.
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