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Nanotoxicology Volume 10, 2016 - Issue 9
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Original Article

Impact of polymer-modified gold nanoparticles on brain endothelial cells: exclusion of endoplasmic reticulum stress as a potential risk factor

Laura AnspachREPAIR-Lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Mainz, Germany,
,
Ronald E. UngerREPAIR-Lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Mainz, Germany,
,
Christoph BrochhausenREPAIR-Lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Mainz, Germany,
,
Matthew I. GibsonDepartment of Chemistry, University of Warwick, Coventry, UK, and
,
Harm-Anton KlokÉcole Polytechnique Fédérale De Lausanne (EPFL), Institut Des Matériaux and Institut Des Sciences Et Ingénierie Chimiques, Laboratoire Des Polymères, Bâtiment MXD, Lausanne, Switzerland
,
C. James KirkpatrickREPAIR-Lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Mainz, Germany,
&
Christian FreeseREPAIR-Lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Mainz, Germany, Correspondence[email protected]
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Pages 1341-1350 | Received 05 Jun 2015, Accepted 13 Jun 2016, Published online: 05 Aug 2016

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Maria Enea, Miguel Peixoto de Almeida, Peter Eaton, Diana Dias da Silva, Eulália Pereira, Maria Elisa Soares, Maria de Lourdes Bastos & Helena Carmo. (2019) A multiparametric study of gold nanoparticles cytotoxicity, internalization and permeability using an in vitro model of blood–brain barrier. Influence of size, shape and capping agent. Nanotoxicology 13:7, pages 990-1004.
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Jeff Ji, Alexandre Moquin, Franck Bertorelle, Philip KY Chang, Rodolphe Antoine, Julia Luo, R. Anne McKinney & Dusica Maysinger. (2019) Organotypic and primary neural cultures as models to assess effects of different gold nanostructures on glia and neurons. Nanotoxicology 13:3, pages 285-304.
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Articles from other publishers (18)

Binjing Li, Ting Zhang & Meng Tang. (2022) Toxicity mechanism of nanomaterials: Focus on endoplasmic reticulum stress. Science of The Total Environment 834, pages 155417.
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Soudeh F. Tehrani, Jean-Michel Rabanel, Samuel Legeay, Jérôme Cayon, Jérémie Riou, Patrick Saulnier, Sylvie Marleau, V. Gaëlle Roullin, Patrice Hildgen & Guillaume Bastiat. (2022) Tailoring PEGylated nanoparticle surface modulates inflammatory response in vascular endothelial cells. European Journal of Pharmaceutics and Biopharmaceutics 174, pages 155-166.
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Iman Zare, Mohammad Tavakkoli Yaraki, Giorgio Speranza, Alireza Hassani Najafabadi, Alireza Shourangiz-Haghighi, Amirala Bakhshian Nik, Bella B. Manshian, Cláudia Saraiva, Stefaan J. Soenen, Marcelo J. Kogan, Jee Woong Lee, Nicholas V. Apollo, Liliana Bernardino, Eyleen Araya, Dirk Mayer, Guangzhao Mao & Michael R. Hamblin. (2022) Gold nanostructures: synthesis, properties, and neurological applications. Chemical Society Reviews 51:7, pages 2601-2680.
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Aniela Bittner, Fabien Gosselet, Emmanuel Sevin, Lucie Dehouck, Angélique D. Ducray, Véronique Gaschen, Michael H. Stoffel, Hansang Cho & Meike Mevissen. (2021) Time-Dependent Internalization of Polymer-Coated Silica Nanoparticles in Brain Endothelial Cells and Morphological and Functional Effects on the Blood-Brain Barrier. International Journal of Molecular Sciences 22:4, pages 1657.
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Atsuto Onoda, Takayasu Kawasaki, Koichi Tsukiyama, Ken Takeda & Masakazu Umezawa. (2020) Carbon nanoparticles induce endoplasmic reticulum stress around blood vessels with accumulation of misfolded proteins in the developing brain of offspring. Scientific Reports 10:1.
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Loutfy H. Madkour. 2020. Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms. Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms 343 372 .
Loutfy H. MadkourLoutfy H. Madkour. 2020. Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses. Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses 403 450 .
Na Liu & Meng Tang. (2019) Toxic effects and involved molecular pathways of nanoparticles on cells and subcellular organelles. Journal of Applied Toxicology 40:1, pages 16-36.
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Dana M. Samhadaneh, Khalid A. Alqarni, Adam Smart, Mohuizi Kuang, Ossama Moujaber, Dusica Maysinger & Ursula Stochaj. (2019) Gold nanourchins induce cellular stress, impair proteostasis and damage RNA. Nanomedicine: Nanotechnology, Biology and Medicine 22, pages 102083.
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Mattaka Khongkow, Teerapong Yata, Suwimon Boonrungsiman, Uracha Rungsardthong Ruktanonchai, Duncan Graham & Katawut Namdee. (2019) Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood–brain barrier penetration. Scientific Reports 9:1.
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Yanbo Li, Ru Ma, Xiaoying Liu, Yi Qi, Alimire Abulikemu, Xinying Zhao, Huawei Duan, Xianqing Zhou, Caixia Guo & Zhiwei Sun. (2019) Endoplasmic reticulum stress-dependent oxidative stress mediated vascular injury induced by silica nanoparticles in vivo and in vitro. NanoImpact 14, pages 100169.
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Yubin Li, Jiajun Fan & Dianwen Ju. 2019. Brain Targeted Drug Delivery System. Brain Targeted Drug Delivery System 377 408 .
Marzieh Mohammadi, Sahar Taghavi, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani & Mona Alibolandi. (2018) Hybrid Vesicular Drug Delivery Systems for Cancer Therapeutics. Advanced Functional Materials 28:36, pages 1802136.
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Caixia Guo, Ru Ma, Xiaoying Liu, Tian Chen, Yang Li, Yang Yu, Junchao Duan, Xianqing Zhou, Yanbo Li & Zhiwei Sun. (2018) Silica nanoparticles promote oxLDL-induced macrophage lipid accumulation and apoptosis via endoplasmic reticulum stress signaling. Science of The Total Environment 631-632, pages 570-579.
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Gerardo González De La Cruz, Patricia Rodríguez-Fragoso, Jorge Reyes-Esparza, Anahí Rodríguez-López, Rocío Gómez-Cansino & Lourdes Rodriguez-Fragoso. 2018. Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications. Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications.
Yi Cao, Jimin Long, Liangliang Liu, Tong He, Leying Jiang, Chunxue Zhao & Zhen Li. (2017) A review of endoplasmic reticulum (ER) stress and nanoparticle (NP) exposure. Life Sciences 186, pages 33-42.
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C. Freese, L. Anspach, R. C. Deller, S.-J. Richards, M. I. Gibson, C. J. Kirkpatrick & R. E. Unger. (2017) Gold nanoparticle interactions with endothelial cells cultured under physiological conditions. Biomaterials Science 5:4, pages 707-717.
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M.I. Hermanns, C. Freese, L. Anspach, V. Grützner, C. Pohl, R.E. Unger & C.J. Kirkpatrick. 2017. Comprehensive Biomaterials II. Comprehensive Biomaterials II 295 334 .

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