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Nanotoxicology Volume 13, 2019 - Issue 5
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Articles

miRNA-378a as a key regulator of cardiovascular health following engineered nanomaterial inhalation exposure

Quincy A. HathawayDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV, USA; ;Mitochondria, Metabolism & Bioenergetics Working Group, West Virginia University School of Medicine, Morgantown, WV, USA; ;Toxicology Working Group, West Virginia University School of Medicine, Morgantown, WV, USA; View further author information
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Andrya J. DurrDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV, USA; ;Mitochondria, Metabolism & Bioenergetics Working Group, West Virginia University School of Medicine, Morgantown, WV, USA; View further author information
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Danielle L. ShepherdDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV, USA; ;Mitochondria, Metabolism & Bioenergetics Working Group, West Virginia University School of Medicine, Morgantown, WV, USA; View further author information
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Mark V. PintiDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV, USA; ;Mitochondria, Metabolism & Bioenergetics Working Group, West Virginia University School of Medicine, Morgantown, WV, USA; View further author information
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Ashley N. BrandeburaRockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV, USA; ;Department of Biochemistry, West Virginia University School of Medicine, Morgantown, WV, USA; View further author information
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Cody E. NicholsImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; View further author information
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Amina KunovacDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV, USA; ;Mitochondria, Metabolism & Bioenergetics Working Group, West Virginia University School of Medicine, Morgantown, WV, USA; View further author information
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William T. GoldsmithToxicology Working Group, West Virginia University School of Medicine, Morgantown, WV, USA; ;Department of Physiology, Pharmacology & Neuroscience, West Virginia University School of Medicine, Morgantown, WV, USA; View further author information
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Sherri A. FriendCDC, National Institute for Occupational Safety and Health, Morgantown, WV, USAView further author information
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Alaeddin B. AbukabdaToxicology Working Group, West Virginia University School of Medicine, Morgantown, WV, USA; ;Department of Physiology, Pharmacology & Neuroscience, West Virginia University School of Medicine, Morgantown, WV, USA; View further author information
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Garrett K. FinkDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV, USA; View further author information
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Timothy R. NurkiewiczToxicology Working Group, West Virginia University School of Medicine, Morgantown, WV, USA; ;Department of Physiology, Pharmacology & Neuroscience, West Virginia University School of Medicine, Morgantown, WV, USA; View further author information
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John M. HollanderDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV, USA; ;Mitochondria, Metabolism & Bioenergetics Working Group, West Virginia University School of Medicine, Morgantown, WV, USA; Correspondence[email protected]
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Pages 644-663 | Received 31 Jul 2018, Accepted 12 Dec 2018, Published online: 01 Feb 2019

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Amina Kunovac, Quincy A. Hathaway, Mark V. Pinti, Andrya J. Durr, Andrew D. Taylor, William T. Goldsmith, Krista L. Garner, Timothy R. Nurkiewicz & John M. Hollander. (2021) Enhanced antioxidant capacity prevents epitranscriptomic and cardiac alterations in adult offspring gestationally-exposed to ENM. Nanotoxicology 15:6, pages 812-831.
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Articles from other publishers (18)

Chuang Wei, Zeyu Jiang, Congcong Li, Peifeng Li & Qinrui Fu. (2023) Nanomaterials Responsive to Endogenous Biomarkers for Cardiovascular Disease Theranostics. Advanced Functional Materials 33:26.
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Carlos Wells, Marta Pogribna, Beverly Lyn‐Cook & George Hammons. 2023. Impact of Engineered Nanomaterials in Genomics and Epigenomics. Impact of Engineered Nanomaterials in Genomics and Epigenomics 145 186 .
Andrya J. Durr, Anna S. Korol, Quincy A. Hathaway, Amina Kunovac, Andrew D. Taylor, Saira Rizwan, Mark V. Pinti & John M. Hollander. (2023) Machine learning for spatial stratification of progressive cardiovascular dysfunction in a murine model of type 2 diabetes mellitus. PLOS ONE 18:5, pages e0285512.
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Qinglin Sun, Tianyu Li, Yang Yu, Yang Li, Zhiwei Sun & Junchao Duan. (2022) The critical role of epigenetic mechanisms involved in nanotoxicology. WIREs Nanomedicine and Nanobiotechnology 14:6.
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Xin Zhong, Yu Chen, Xiangdang Long, Hongtian Chen, Zhaofen Zheng, Hongwei Pan, Jianqiang Peng, Yanfu Liu, Haijun Wang & Yongjun Hu. (2022) Ultrasound-targeted microbubble destruction (UTMD)-mediated miR-150-5p attenuates oxygen and glucose deprivation-induced cardiomyocyte injury by inhibiting TTC5 expression. Molecular Biology Reports 49:7, pages 6041-6052.
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Andrya J. Durr, Quincy A. Hathaway, Amina Kunovac, Andrew D. Taylor, Mark V. Pinti, Saira Rizwan, Danielle L. Shepherd, Chris C. Cook, Garrett K. Fink & John M. Hollander. (2022) Manipulation of the miR-378a/mt-ATP6 regulatory axis rescues ATP synthase in the diabetic heart and offers a novel role for lncRNA Kcnq1ot1. American Journal of Physiology-Cell Physiology 322:3, pages C482-C495.
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Quincy A. Hathaway, Nairrita Majumder, William T. Goldsmith, Amina Kunovac, Mark V. Pinti, Jack R. Harkema, Vince Castranova, John M. Hollander & Salik Hussain. (2021) Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction. Particle and Fibre Toxicology 18:1.
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Xiaoting Jin, Haiyi Yu, Ze Zhang, Tenglong Cui, Qi Wu, Xiaolei Liu, Jie Gao, Xingchen Zhao, Jianbo Shi, Guangbo Qu & Guibin Jiang. (2021) Surface charge-dependent mitochondrial response to similar intracellular nanoparticle contents at sublethal dosages. Particle and Fibre Toxicology 18:1.
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Sara B. Fournier, Vincent Lam, Michael J. Goedken, Laura Fabris & Phoebe A. Stapleton. (2021) Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation. Scientific Reports 11:1.
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Dong Li, Yan Yang, Youping Li, Xiaohua Zhu & Zeqin Li. (2021) Epigenetic regulation of gene expression in response to environmental exposures: From bench to model. Science of The Total Environment 776, pages 145998.
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Zonghu Wu. (2021) Role of microRNA-24 Transfection Mediated by Silica Nanoparticles in Apoptosis of Cardiomyocyte. Science of Advanced Materials 13:3, pages 455-462.
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Thiagarajan Raman. 2021. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure 459 477 .
Sara B. Fournier, Jeanine N. D’Errico, Derek S. Adler, Stamatina Kollontzi, Michael J. Goedken, Laura Fabris, Edward J. Yurkow & Phoebe A. Stapleton. (2020) Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy. Particle and Fibre Toxicology 17:1.
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Weiyuan Zhang, Sicheng Liu, Dan Han & Zhiyong He. (2020) Engineered nanoparticle-induced epigenetic changes: An important consideration in nanomedicine. Acta Biomaterialia 117, pages 93-107.
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Zhen Luo, Zhuoqing Li, Zhe Xie, Inna M. Sokolova, Lan Song, Willie J. G. M. Peijnenburg, Menghong Hu & Youji Wang. (2020) Rethinking Nano‐TiO 2 Safety: Overview of Toxic Effects in Humans and Aquatic Animals . Small 16:36, pages 2002019.
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Amina Kunovac, Quincy A. Hathaway, Mark V. Pinti, Andrew D. Taylor & John M. Hollander. (2020) Cardiovascular adaptations to particle inhalation exposure: molecular mechanisms of the toxicology. American Journal of Physiology-Heart and Circulatory Physiology 319:2, pages H282-H305.
Crossref
Amina Kunovac, Quincy A. Hathaway, Mark V. Pinti, William T. Goldsmith, Andrya J. Durr, Garrett K. Fink, Timothy R. Nurkiewicz & John M. Hollander. (2019) ROS promote epigenetic remodeling and cardiac dysfunction in offspring following maternal engineered nanomaterial (ENM) exposure. Particle and Fibre Toxicology 16:1.
Crossref
Quincy A. Hathaway, Skyler M. Roth, Mark V. Pinti, Daniel C. Sprando, Amina Kunovac, Andrya J. Durr, Chris C. Cook, Garrett K. Fink, Tristen B. Cheuvront, Jasmine H. Grossman, Ghadah A. Aljahli, Andrew D. Taylor, Andrew P. Giromini, Jessica L. Allen & John M. Hollander. (2019) Machine-learning to stratify diabetic patients using novel cardiac biomarkers and integrative genomics. Cardiovascular Diabetology 18:1.
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