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Nanotoxicology Volume 14, 2020 - Issue 2
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A multi-omics approach reveals mechanisms of nanomaterial toxicity and structure–activity relationships in alveolar macrophages

Anne BannuscherDepartment of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany; View further author information
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Isabel KarkossaDepartment of Molecular Systems Biology, UFZ, Helmholtz-Centre for Environmental Research, Leipzig, Germany; ORCID Iconhttp://orcid.org/0000-0003-2781-1877View further author information
ORCID Icon,
Sophia BuhsResearch Institute Children’s Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ;Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; View further author information
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Peter NollauResearch Institute Children’s Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ;Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; View further author information
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Katja KettlerDepartment of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany; View further author information
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Mihaela BalasDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Bucharest, Romania; View further author information
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Anca DinischiotuDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Bucharest, Romania; View further author information
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Bryan HellackInstitute of Energy and Environmental Technology (IUTA) e.V, Duisburg, Germany; ;German Environment Agency, Dessau, Germany; View further author information
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Martin WiemannIBE R&D gGmbH Institute for Lung Health, Münster, Germany; View further author information
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Andreas LuchDepartment of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany; View further author information
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Martin von BergenDepartment of Molecular Systems Biology, UFZ, Helmholtz-Centre for Environmental Research, Leipzig, Germany; ;Institute of Biochemistry, Leipzig University, Leipzig, GermanyORCID Iconhttp://orcid.org/0000-0003-2732-2977View further author information
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Andrea HaaseDepartment of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany; View further author information
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Kristin SchubertDepartment of Molecular Systems Biology, UFZ, Helmholtz-Centre for Environmental Research, Leipzig, Germany; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-4365-084XView further author information
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Pages 181-195 | Received 19 Jul 2019, Accepted 21 Oct 2019, Published online: 27 Nov 2019

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Kaiwen Li, Zhongwei Wang, Hui Zeng, Jing Sun, Yue Wang, Qixing Zhou & Xiangang Hu. (2021) Surface atomic arrangement of nanomaterials affects nanotoxicity. Nanotoxicology 15:1, pages 114-130.
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Theresa Streidl, Isabel Karkossa, Rafael R. Segura Muñoz, Claudia Eberl, Alex Zaufel, Johannes Plagge, Robert Schmaltz, Kristin Schubert, Marijana Basic, Kai Markus Schneider, Mamdouh Afify, Christian Trautwein, René Tolba, Bärbel Stecher, Heidi L. Doden, Jason M. Ridlon, Josef Ecker, Tarek Moustafa, Martin von Bergen, Amanda E. Ramer-Tait & Thomas Clavel. (2021) The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice. Gut Microbes 13:1.
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Anne Bannuscher, Bryan Hellack, Aileen Bahl, Julie Laloy, Hildegard Herman, Miruna S. Stan, Anca Dinischiotu, Anna Giusti, Benjamin-Christoph Krause, Jutta Tentschert, Marcel Roșu, Cornel Balta, Anca Hermenean, Martin Wiemann, Andreas Luch & Andrea Haase. (2020) Metabolomics profiling to investigate nanomaterial toxicity in vitro and in vivo. Nanotoxicology 14:6, pages 807-826.
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Giulia Mancardi, Alicja Mikolajczyk, Vigneshwari K. Annapoorani, Aileen Bahl, Kostas Blekos, Jaanus Burk, Yarkın A. Çetin, Konstantinos Chairetakis, Sutapa Dutta, Laura Escorihuela, Karolina Jagiello, Ankush Singhal, Rianne van der Pol, Miguel A. Bañares, Nicolae-Viorel Buchete, Monica Calatayud, Verónica I. Dumit, Davide Gardini, Nina Jeliazkova, Andrea Haase, Effie Marcoulaki, Benjamí Martorell, Tomasz Puzyn, G.J. Agur Sevink, Felice C. Simeone, Kaido Tämm & Eliodoro Chiavazzo. (2023) A computational view on nanomaterial intrinsic and extrinsic features for nanosafety and sustainability. Materials Today.
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Mohammad Awashra & Piotr Młynarz. (2023) The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective . Nanoscale Advances 5:10, pages 2674-2723.
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Bjoern Titz, Oksana Lavrynenko & Nikolai V. Ivanov. 2023. Mass Spectrometry for Lipidomics. Mass Spectrometry for Lipidomics 625 639 .
Alexandra Schaffert, Isabel Karkossa, Elke Ueberham, Rita Schlichting, Katharina Walter, Josi Arnold, Matthias Blüher, John T. Heiker, Jörg Lehmann, Martin Wabitsch, Beate I. Escher, Martin von Bergen & Kristin Schubert. (2022) Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic homeostasis in mature adipocytes. Environment International 164, pages 107279.
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Yinglin Xia & Jun Sun. 2022. Statistical Data Analysis of Microbiomes and Metabolomics. Statistical Data Analysis of Microbiomes and Metabolomics.
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Katharina Walter, Henning Grosskopf, Isabel Karkossa, Martin von Bergen & Kristin Schubert. (2021) Proteomic Characterization of the Cellular Effects of AhR Activation by Microbial Tryptophan Catabolites in Endotoxin-Activated Human Macrophages. International Journal of Environmental Research and Public Health 18:19, pages 10336.
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Alexandra Schaffert, Josi Arnold, Isabel Karkossa, Matthias Blüher, Martin von Bergen & Kristin Schubert. (2021) The Emerging Plasticizer Alternative DINCH and Its Metabolite MINCH Induce Oxidative Stress and Enhance Inflammatory Responses in Human THP-1 Macrophages. Cells 10:9, pages 2367.
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Farooq Ahmad, Asif Mahmood & Tahir Muhmood. (2021) Machine learning-integrated omics for the risk and safety assessment of nanomaterials. Biomaterials Science 9:5, pages 1598-1608.
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Qin Zhang, Xinghang Dai, Hu Zhang, Yujun Zeng, Kui Luo & Weimin Li. (2021) Recent advances in development of nanomedicines for multiple sclerosis diagnosis. Biomedical Materials 16:2, pages 024101.
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Zhipeng Wang, Isabel Karkossa, Henning Großkopf, Ulrike Rolle-Kampczyk, Jörg Hackermüller, Martin von Bergen & Kristin Schubert. (2021) Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology 448, pages 152652.
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Carolina Madeira & Pedro M. Costa. 2021. Proteomics and Systems Biology. Proteomics and Systems Biology 55 91 .
Konstantin Pikula & Kirill Golokhvast. 2021. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure 495 514 .
Evgeny Ogorodnik, Arpad Karsai, Kang-Hsin Wang, Fu-tong Liu, Su Hao Lo, Kent E. Pinkerton, Benjamin Gilbert, Dominik R. Haudenschild & Gang-yu Liu. (2020) Direct Observations of Silver Nanowire-Induced Frustrated Phagocytosis among NR8383 Lung Alveolar Macrophages. The Journal of Physical Chemistry B 124:51, pages 11584-11592.
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Isabel Karkossa, Stefanie Raps, Martin von Bergen & Kristin Schubert. (2020) Systematic Review of Multi-Omics Approaches to Investigate Toxicological Effects in Macrophages. International Journal of Molecular Sciences 21:24, pages 9371.
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Kelly Fraser, Vamsi Kodali, Naveena Yanamala, M. Eileen Birch, Lorenzo Cena, Gary Casuccio, Kristin Bunker, Traci L. Lersch, Douglas E. Evans, Aleksandr Stefaniak, Mary Ann Hammer, Michael L. Kashon, Theresa Boots, Tracy Eye, John Hubczak, Sherri A. Friend, Matthew Dahm, Mary K. Schubauer-Berigan, Katelyn Siegrist, David Lowry, Alison K. Bauer, Linda M. Sargent & Aaron Erdely. (2020) Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities. Particle and Fibre Toxicology 17:1.
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Wei Zou, Xinyu Li, Chonghao Li, Yuanyuan Sun, Xingli Zhang, Caixia Jin, Kai Jiang, Qixing Zhou & Xiangang Hu. (2020) Influence of Size and Phase on the Biodegradation, Excretion, and Phytotoxicity Persistence of Single-Layer Molybdenum Disulfide. Environmental Science & Technology 54:19, pages 12295-12306.
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