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Expert Review of Clinical Immunology Volume 12, 2016 - Issue 11
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Review

Restoring regulation – IL-2 therapy in systemic lupus erythematosus

Jens Y. HumrichDepartment of Rheumatology, University Hospital Schleswig-Holstein, Lübeck, GermanyCorrespondence[email protected]
&
Gabriela RiemekastenDepartment of Rheumatology, University Hospital Schleswig-Holstein, Lübeck, Germany
Pages 1153-1160 | Received 16 Mar 2016, Accepted 07 Jun 2016, Published online: 23 Jun 2016

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Soledad Retamozo, Antoni Sisó-Almirall, Alejandra Flores-Chávez, Manuel Ramos-Casals & Pilar Brito-Zerón. (2021) An update of targeted therapeutic options for primary Sjögren syndrome: current status and future development. Expert Opinion on Pharmacotherapy 22:17, pages 2359-2371.
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Articles from other publishers (33)

Stefan Rosenberger, Reinmar Undeutsch, Reza Akbarzadeh, Justus Ohmes, Philipp Enghard, Gabriela Riemekasten & Jens Y. Humrich. (2023) Regulatory T cells inhibit autoantigen-specific CD4+ T cell responses in lupus-prone NZB/W F1 mice. Frontiers in Immunology 14.
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Lijing Shang, Linfeng He & Mengjiao Li. (2023) What exactly is the relationship between plasma cytokines and the clinical phenotype of primary sjögren's syndrome? a single-centre retrospective study. International Immunopharmacology 122, pages 110567.
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Reza Akbarzadeh, Gabriela Riemekasten & Jens Y. Humrich. (2023) Low-dose interleukin-2 therapy: a promising targeted therapeutic approach for systemic lupus erythematosus. Current Opinion in Rheumatology 35:2, pages 98-106.
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He‐Tong Li, Sheng‐Xiao Zhang, Jia‐Qi Zhang, Ting Cheng, Yan Liu, Hong‐Qi Liu, Min Hao & Jun‐Wei Chen. (2022) A decreased number of circulating regulatory T cells is associated with adverse pregnancy outcomes in patients with systemic lupus erythematosus. Immunity, Inflammation and Disease 10:12.
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Justus Ohmes, Sara Comdühr, Reza Akbarzadeh, Gabriela Riemekasten & Jens Y. Humrich. (2022) Dysregulation and chronicity of pathogenic T cell responses in the pre-diseased stage of lupus. Frontiers in Immunology 13.
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Camelia Frantz, Anne Cauvet, Aurélie Durand, Virginie Gonzalez, Rémi Pierre, Marcio Do Cruzeiro, Karine Bailly, Muriel Andrieu, Cindy Orvain, Jérôme Avouac, Mina Ottaviani, Raphaël Thuillet, Ly Tu, Christophe Guignabert, Bruno Lucas, Cédric Auffray & Yannick Allanore. (2022) Driving Role of Interleukin‐2–Related Regulatory CD4 + T Cell Deficiency in the Development of Lung Fibrosis and Vascular Remodeling in a Mouse Model of Systemic Sclerosis . Arthritis & Rheumatology 74:8, pages 1387-1398.
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Zhan Xu, Xue Jiang, Xueyu Dai & Bin Li. (2022) The Dynamic Role of FOXP3+ Tregs and Their Potential Therapeutic Applications During SARS-CoV-2 Infection. Frontiers in Immunology 13.
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Christie Fanton, Richard Furie, Vishala Chindalore, Robert Levin, Isam Diab, Neha Dixit, Cat Haglund, Jacqueline Gibbons, Nathan Hanan, Daniel Dickerson, Jonathan Zalevsky & Brian L. Kotzin. (2022) Selective expansion of regulatory T cells by NKTR-358 in healthy volunteers and patients with systemic lupus erythematosus. Journal of Translational Autoimmunity 5, pages 100152.
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Ahed J. AlkhatibAhed J. Alkhatib. 2022. The Role of Microbes in Autoimmune Diseases. The Role of Microbes in Autoimmune Diseases 81 103 .
Xinpeng Chen, Xiuxia Luo, Yazhi Wei, Hualin Sun, Liping Dai, Yidou Tangzhou, Huijie Jin & Zhihua Yin. (2021) LncRNA H19 induces immune dysregulation of BMMSCs, at least partly, by inhibiting IL-2 production. Molecular Medicine 27:1.
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Antonios G. A. Kolios, George C. Tsokos & David Klatzmann. (2021) Interleukin-2 and regulatory T cells in rheumatic diseases. Nature Reviews Rheumatology 17:12, pages 749-766.
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Jenny H. Xie, Yifan Zhang, Martine Loubeau, Paul Mangan, Elizabeth Heimrich, Christian Tovar, Xiadi Zhou, Priyanka Madia, Michael Doyle, Shailesh Dudhgaonkar, Anjuman Rudra, Siva Subramani, James Young, Luisa Salter-Cid, Thomas R. Malek & Mary Struthers. (2021) Mouse IL-2/CD25 Fusion Protein Induces Regulatory T Cell Expansion and Immune Suppression in Preclinical Models of Systemic Lupus Erythematosus. The Journal of Immunology 207:1, pages 34-43.
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Hanna Graßhoff, Sara Comdühr, Luisa R. Monne, Antje Müller, Peter Lamprecht, Gabriela Riemekasten & Jens Y. Humrich. (2021) Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases. Frontiers in Immunology 12.
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Amrita Srivastava & Helen P. Makarenkova. (2020) Innate Immunity and Biological Therapies for the Treatment of Sjögren’s Syndrome. International Journal of Molecular Sciences 21:23, pages 9172.
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Bradley G. Phillips, Ye Wang, Suresh Ambati, Ping Ma & Richard B. Meagher. (2020) Airways therapy of obstructive sleep apnea dramatically improves aberrant levels of soluble cytokines involved in autoimmune disease. Clinical Immunology 221, pages 108601.
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Marcela Davoli-Ferreira, Kalil A. de Lima, Miriam M. Fonseca, Rafaela M. Guimarães, Francisco I. Gomes, Maria C. Cavallini, Andreza U. Quadros, Ricardo Kusuda, Fernando Q. Cunha, Jose C. Alves-Filho & Thiago M. Cunha. (2020) Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury. Pain 161:8, pages 1730-1743.
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Geng-He Chang, Yi-Cheng Su, Ko-Ming Lin, Chia-Yen Liu, Yao-Hsu Yang, Pey-Jium Chang, Meng-Hung Lin, Chuan-Pin Lee, Cheng-Ming Hsu, Yao-Te Tsai, Ching-Yuan Wu & Ming-Shao Tsai. (2020) Deep Neck Infection in Systemic Lupus Erythematosus Patients: Real-World Evidence. Scientific Reports 10:1.
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Jonathan G. Pol, Pamela Caudana, Juliette Paillet, Eliane Piaggio & Guido Kroemer. (2020) Effects of interleukin-2 in immunostimulation and immunosuppression. Journal of Experimental Medicine 217:1.
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Maryam Tahvildari & Reza Dana. (2019) Low-Dose IL-2 Therapy in Transplantation, Autoimmunity, and Inflammatory Diseases. The Journal of Immunology 203:11, pages 2749-2755.
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Angelika Rose, Caroline von Spee-Mayer, Lutz Kloke, Kaiyin Wu, Anja Kühl, Philipp Enghard, Gerd-Rüdiger Burmester, Gabriela Riemekasten & Jens Humrich. (2019) IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis. Cells 8:10, pages 1234.
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Richard A. Proctor. 2019. Gram-Positive Pathogens. Gram-Positive Pathogens 766 775 .
Richard A. Proctor. (2019) Immunity to Staphylococcus aureus : Implications for Vaccine Development . Microbiology Spectrum 7:4.
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Dominik Samotij & Adam Reich. (2019) Biologics in the Treatment of Lupus Erythematosus: A Critical Literature Review. BioMed Research International 2019, pages 1-17.
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Jens Y. Humrich & Gabriela Riemekasten. (2019) Low-dose interleukin-2 therapy for the treatment of systemic lupus erythematosus. Current Opinion in Rheumatology 31:2, pages 208-212.
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Anastasia Tsanaktsi, Elena E. Solomou & Stamatis-Nick C. Liossis. (2018) Th1/17 cells, a subset of Th17 cells, are expanded in patients with active systemic lupus erythematosus. Clinical Immunology 195, pages 101-106.
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Paul K. Wallace. (2018) Issue Highlights-May 2018 (94B3). Cytometry Part B: Clinical Cytometry 94:3, pages 387-391.
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Jiakui Zhang, Yanjie Ruan, Xuanxuan Xu, Huiping Wang, Qianshan Tao, Jun Lu, Linhuan Xia, Qiuye Zhang, Jeffrey Wang, Yiping Wang & Zhimin Zhai. (2018) Therapeutic potential of low-dose IL-2 in immune thrombocytopenia: An analysis of 3 cases. Cytometry Part B: Clinical Cytometry 94:3, pages 428-433.
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Masayuki Mizui & George C. Tsokos. (2018) Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus. Frontiers in Immunology 9.
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Soledad Retamozo, Alejandra Flores-Chavez, Marta Consuegra-Fernández, Francisco Lozano, Manuel Ramos-Casals & Pilar Brito-Zerón. (2018) Cytokines as therapeutic targets in primary Sjögren syndrome. Pharmacology & Therapeutics 184, pages 81-97.
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Frank A. Wollheim. (2018) T-regulatory cells—Triumph of perseverance: The Crafoord Prize for Polyarthritis in 2017. Seminars in Arthritis and Rheumatism 47:4, pages 601-603.
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Yovana Pacheco, Julián Barahona-Correa, Diana M. Monsalve, Yeny Acosta-Ampudia, Manuel Rojas, Yhojan Rodríguez, Juliana Saavedra, Mónica Rodríguez-Jiménez, Rubén D. Mantilla, Carolina Ramírez-Santana, Nicolás Molano-González & Juan-Manuel Anaya. (2017) Cytokine and autoantibody clusters interaction in systemic lupus erythematosus. Journal of Translational Medicine 15:1.
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Jens Y. Humrich & Gabriela Riemekasten. (2016) The rise of IL-2 therapy — a novel biologic treatment for SLE. Nature Reviews Rheumatology 12:12, pages 695-696.
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Masayuki Mizui & George C. Tsokos. (2016) Low-Dose IL-2 in the Treatment of Lupus. Current Rheumatology Reports 18:11.
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