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Expert Review of Clinical Immunology Volume 15, 2019 - Issue 7
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Original Research

Additive immunosuppressive effect of leflunomide and hydroxychloroquine supports rationale for combination therapy for Sjögren’s syndrome

Eefje HM van der HeijdenDepartment of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands;Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsView further author information
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Sarita AY HartgringDepartment of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands;Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsView further author information
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Aike A KruizeLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsView further author information
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Timothy RDJ RadstakeDepartment of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands;Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsCorrespondence[email protected]
View further author information
&
Joel AG van RoonDepartment of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands;Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsView further author information
Pages 801-808 | Received 25 Mar 2019, Accepted 24 May 2019, Published online: 13 Jun 2019

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Robert I. Fox, Carla M. Fox & Sara S. McCoy. (2023) Emerging treatment for Sjögren’s disease: a review of recent phase II and III trials. Expert Opinion on Emerging Drugs 28:2, pages 107-120.
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Emiko Desvaux, Audrey Aussy, Sandra Hubert, Florence Keime-Guibert, Alexia Blesius, Perrine Soret, Mickaël Guedj, Jacques-Olivier Pers, Laurence Laigle & Philippe Moingeon. (2022) Model-based computational precision medicine to develop combination therapies for autoimmune diseases. Expert Review of Clinical Immunology 18:1, pages 47-56.
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Articles from other publishers (11)

P. Sangeetha Vijayan, Joseph Xavier & Mohanan Parayanthala Valappil. (2023) A review of immune modulators and immunotherapy in infectious diseases. Molecular and Cellular Biochemistry.
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Safae Hamkour, Eefje HM van der Heijden, Ana P Lopes, Sofie L M Blokland, Cornelis P J Bekker, Cornelia G Van Helden-Meeuwsen, Marjan A Versnel, Aike A Kruize, Timothy RDJ Radstake, Helen L Leavis, Maarten R Hillen & Joel AG van Roon. (2023) Leflunomide/hydroxychloroquine combination therapy targets type I IFN-associated proteins in patients with Sjögren’s syndrome that show potential to predict and monitor clinical response. RMD Open 9:3, pages e002979.
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Wen-Shuang Fan, Hong-Thai Nguyen, Ching-Yu Wang, Shih-Wun Liang, Yu-Ming Tsao, Fen-Chi Lin & Hsiang-Chen Wang. (2023) Detection of Hydroxychloroquine Retinopathy via Hyperspectral and Deep Learning through Ophthalmoscope Images. Diagnostics 13:14, pages 2373.
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Chao Yu, Jie Zou, Qian-Min Ge, Xu-Lin Liao, Yi-Cong Pan, Jie-Li Wu, Ting Su, Li-Juan Zhang, Rong-Bin Liang & Yi Shao. (2023) Ocular microvascular alteration in Sjögren’s syndrome treated with hydroxychloroquine: an OCTA clinical study. Therapeutic Advances in Chronic Disease 14, pages 204062232311644.
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James C. Barton, J. Clayborn Barton & Luigi F. Bertoli. (2022) Hydroxychloroquine Therapy and Serum Immunoglobulin Levels in Women with IgG Subclass Deficiency and Systemic Lupus Erythematosus, Sjögren Syndrome, and Rheumatoid Arthritis: A Retrospective Study. Archivum Immunologiae et Therapiae Experimentalis 70:1.
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Anneline C. Hinrichs, Aike A. Kruize, Helen L. Leavis & Joel A. G. van Roon. (2022) In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells. Frontiers in Immunology 13.
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Alina Dima, Ciprian Jurcut & Laurent Arnaud. (2021) Hydroxychloroquine dans les maladies systémiques et auto-immunes : où en sommes-nous ?. Revue du Rhumatisme 88:5, pages 346-353.
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Alina Dima, Ciprian Jurcut & Laurent Arnaud. (2021) Hydroxychloroquine in systemic and autoimmune diseases: Where are we now?. Joint Bone Spine 88:3, pages 105143.
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Elodie Rivière, Juliette Pascaud, Nicolas Tchitchek, Saida Boudaoud, Audrey Paoletti, Bineta Ly, Anastasia Dupré, Hua Chen, Alice Thai, Norm Allaire, Bernd Jagla, Michael Mingueneau, Gaetane Nocturne & Xavier Mariette. (2020) Salivary gland epithelial cells from patients with Sjögren’s syndrome induce B-lymphocyte survival and activation. Annals of the Rheumatic Diseases 79:11, pages 1468-1477.
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Jing Wang, Lingyan Zhou & Bin Liu. (2020) Update on disease pathogenesis, diagnosis, and management of primary Sjögren’s syndrome. International Journal of Rheumatic Diseases 23:6, pages 723-727.
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Eefje Hanna Martine van der Heijden, Sofie Liny Marie Blokland, Maarten Reinier Hillen, Ana Paula Pinheiro Lopes, Fréderique Marie van Vliet-Moret, Antoine Johan Wilhelm Peter Rosenberg, Nard Gabriëlle Janssen, Paco Mattheus Jacobus Welsing, Valentina Iannizzotto, Weiyang Tao, Aridaman Pandit, Francesca Barone, Aike Albert Kruize, Timothy Ruben Dirk Jan Radstake & Joel Adrianus Gijsbert van Roon. (2020) Leflunomide–hydroxychloroquine combination therapy in patients with primary Sjögren's syndrome (RepurpSS-I): a placebo-controlled, double-blinded, randomised clinical trial. The Lancet Rheumatology 2:5, pages e260-e269.
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