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Expert Review of Clinical Immunology Volume 15, 2019 - Issue 10
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Review

Autoantibodies to protein-arginine deiminase (PAD) 4 in rheumatoid arthritis: immunological and clinical significance, and potential for precision medicine

Anti-PAD4 antibodies in RA

Laura Martinez-Prata Research and Development, Inova Diagnostics, San Diego, CA, USA;b Department of Experimental Science, Francisco de Vitoria University, Madrid, SpainView further author information
,
Boaz Paltererc specialist in Allergy and Clinical Immunology, Experimental and Clinical Medicine Department, University of Florence, Florence, ItalyView further author information
,
Gianfranco Vitiellod resident in Allergy and Clinical Immunology, Experimental and Clinical Medicine Department, University of Florence, Florence, ItalyView further author information
,
Paola Parronchie (Allergy and Clinical Immunology), Laboratory Head, Experimental and Clinical Medicine Department, University of Florence, Florence, ItalyView further author information
,
William H. Robinsonf (Immunology and Rheumatology), Division of Immunology and Rheumatology, Stanford University, Stanford, CA, USA;g Geriatric Research Education and Clinical [GRECC] Division, VA Palo Alto Health Care System, Palo Alto, CA, USAView further author information
&
Michael Mahlera Research and Development, Inova Diagnostics, San Diego, CA, USACorrespondence[email protected]
View further author information
Pages 1073-1087 | Received 01 May 2019, Accepted 13 Sep 2019, Published online: 13 Oct 2019

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Mohammed F. Alghamdi & Elrashdy M. Redwan. (2021) Advances in the diagnosis of autoimmune diseases based on citrullinated peptides/proteins. Expert Review of Molecular Diagnostics 21:7, pages 685-702.
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Articles from other publishers (18)

Guangyue Zhang, Jiayi Xu, Dongru Du, Yi Liu, Lunzhi Dai & Yi Zhao. (2023) Diagnostic values, association with disease activity and possible risk factors of anti-PAD4 in rheumatoid arthritis: a meta-analysis. Rheumatology.
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Boaz Palterer, Gianfranco Vitiello, Marco Del Carria, Bernardo D’Onofrio, Laura Martinez-Prat, Michael Mahler, Daniele Cammelli & Paola Parronchi. (2023) Anti-protein arginine deiminase antibodies are distinctly associated with joint and lung involvement in rheumatoid arthritis. Rheumatology 62:7, pages 2410-2417.
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Esther Sánchez-Tirado, Lourdes Agüí, Marta Sánchez-Paniagua, Araceli González-Cortés, Beatriz López-Ruiz, Paloma Yáñez-Sedeño & José M. Pingarrón. (2023) Serum Autoantibody Biomarkers for Management of Rheumatoid Arthritis Disease. Biosensors 13:3, pages 381.
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Chandru Gajendran, Shoichi Fukui, Naveen M. Sadhu, Mohammed Zainuddin, Sridharan Rajagopal, Ramachandraiah Gosu, Sarah Gutch, Saeko Fukui, Casey E. Sheehy, Long Chu, Santosh Vishwakarma, D. A. Jeyaraj, Gurulingappa Hallur, Denisa D. Wagner & Dhanalakshmi Sivanandhan. (2023) Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4. Scientific Reports 13:1.
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Laura Martinez-Prat, Victor Martinez-Taboada, Cruz Santos, Marcos Lopez-Hoyos & Michael Mahler. (2022) Anti-Protein-Arginine Deiminase 4 IgG and IgA Delineate Severe Rheumatoid Arthritis. Diagnostics 12:9, pages 2187.
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Marek Ciesla, Bogdan Kolarz & Dorota Darmochwal-Kolarz. (2022) The lack of association between PADI4_94 or PADI4_104 polymorphisms and RF, ACPA and anti-PAD4 in patients with rheumatoid arthritis. Scientific Reports 12:1.
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Samuel Asamoah Sakyi, Andy Opoku Boateng, Linda Ahenkorah Fondjo, Kwame Yeboah Mensah, Stephen Opoku, Ebenezer Senu, Tonnies Abeku Buckman & Joseph Entwi Sampson. (2022) Polymorphism of protein tyrosine phosphatase non‐receptor type 22 and protein arginine deiminase 4 gene among Ghanaian rheumatoid arthritis patients: A case–control study. International Journal of Rheumatic Diseases 25:7, pages 781-786.
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Jia He, JiYu Ju & XiaoDong Wang. (2021) The current status of anti-citrullinated protein antibodies and citrullinated protein-reactive B cells in the pathogenesis of rheumatoid arthritis. Molecular Biology Reports 49:3, pages 2475-2485.
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Luigi Cinquanta, Maria Infantino & Nicola Bizzaro. (2022) Detecting Autoantibodies by Multiparametric Assays: Impact on Prevention, Diagnosis, Monitoring, and Personalized Therapy in Autoimmune Diseases. The Journal of Applied Laboratory Medicine 7:1, pages 137-150.
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Elrashdy M. Redwan, Mohammed F. Alghamdi, Tarek Mohamed Abd El-Aziz, Parise Adadi, Alaa A.A. Aljabali, Diksha Attrish, Gajendra Kumar Azad, Wagner Baetas-da-Cruz, Debmalya Barh, Nicolas G. Bazan, Adam M. Brufsky, Gaurav Chauhan, S.K. Sarif Hassan, Ramesh Kandimalla, Amos Lal, Kenneth Lundstrom, Yogendra Kumar Mishra, Pabitra Pal Choudhury, Giorgio Palù, Pritam K. Panda, Damiano Pizzol, Nima Rezaei, Ángel Serrano-Aroca, Samendra P. Sherchan, Murat Seyran, Kazuo Takayama, Murtaza M. Tambuwala, Bruce D. Uhal & Vladimir N. Uversky. (2021) The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19. Autoimmunity Reviews 20:10, pages 102909.
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Chang-Youh Tsai, Song-Chou Hsieh, Chih-Wei Liu, Cheng-Hsun Lu, Hsien-Tzung Liao, Ming-Han Chen, Ko-Jen Li, Cheng-Han Wu, Cheih-Yu Shen, Yu-Min Kuo & Chia-Li Yu. (2021) The Expression of Non-Coding RNAs and Their Target Molecules in Rheumatoid Arthritis: A Molecular Basis for Rheumatoid Pathogenesis and Its Potential Clinical Applications. International Journal of Molecular Sciences 22:11, pages 5689.
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D. A. Dibrov. (2021) New laboratory biomarkers of rheumatoid arthritis. Rheumatology Science and Practice 59:2, pages 201-207.
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Yu Zhang, Yiqiong Yang, Xiuxiu Hu, Zhi Wang, Li Li & Pingsheng Chen. (2021) PADs in cancer: Current and future. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1875:1, pages 188492.
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Jie Li, Rong‐Shuang Tang, Zhou Shi & Jin‐Qi Li. (2020) Nuclear factor‐κB in rheumatoid arthritis. International Journal of Rheumatic Diseases 23:12, pages 1627-1635.
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Timothy J. Bowden, Igor Kraev & Sigrun Lange. (2020) Extracellular vesicles and post-translational protein deimination signatures in haemolymph of the American lobster (Homarus americanus). Fish & Shellfish Immunology 106, pages 79-102.
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Timothy J. Bowden, Igor Kraev & Sigrun Lange. (2020) Post-translational protein deimination signatures and extracellular vesicles (EVs) in the Atlantic horseshoe crab (Limulus polyphemus). Developmental & Comparative Immunology 110, pages 103714.
Crossref
Michael Mahler, Laura Martinez-Prat, Jeffrey A. Sparks & Kevin D. Deane. (2020) Precision medicine in the care of rheumatoid arthritis: Focus on prediction and prevention of future clinically-apparent disease. Autoimmunity Reviews 19:5, pages 102506.
Crossref
Michael F. Criscitiello, Igor Kraev, Lene H. Petersen & Sigrun Lange. (2020) Deimination Protein Profiles in Alligator mississippiensis Reveal Plasma and Extracellular Vesicle-Specific Signatures Relating to Immunity, Metabolic Function, and Gene Regulation. Frontiers in Immunology 11.
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