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Review

Impact of low tacrolimus exposure and high tacrolimus intra-patient variability on the development of de novo anti-HLA donor-specific antibodies in kidney transplant recipients

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Pages 1323-1331 | Received 30 Jul 2019, Accepted 12 Nov 2019, Published online: 27 Nov 2019

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Alexandra L Degraeve, Serge Moudio, Vincent Haufroid, Djamila Chaib Eddour, Michel Mourad, Laure B Bindels & Laure Elens. (2020) Predictors of tacrolimus pharmacokinetic variability: current evidences and future perspectives. Expert Opinion on Drug Metabolism & Toxicology 16:9, pages 769-782.
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Articles from other publishers (20)

Pengpeng Guo, Rui Zhang, Jinping Zhou, Peixia Li, Yani Liu & Shaojun Shi. (2024) Intracellular tacrolimus concentration correlates with impaired renal function through regulation of the IS-AHR-ABC transporter in peripheral blood mononuclear cells. International Immunopharmacology 126, pages 111233.
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Gregory Petrossian, Jorge Ortiz, Alejandro Chiodo Ortiz, Kathryn Addonizio, Alexander Hsiao, Rosy James, Naoru Koizumi, Sunil Patel & Robert Plews. (2023) Increased CMV disease and “severe” BK viremia with belatacept vs. sirolimus three-drug maintenance immunosuppression. Transplant Immunology 79, pages 101857.
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Timna Agur, Ruth Rahamimov, Boris Zingerman, Dana Bielopolski, Shelly Lichtenberg, Eviatar Nesher & Benaya Rozen‐Zvi. (2022) Exposure to tacrolimus trough levels below 6 ng/ml during the first year is associated with inferior kidney graft survival. Clinical Transplantation 37:3.
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Alberto MELLA, Maria C. TORAZZA, Daniela FINOCCHIETTI, Fabrizio FOP, Anna ALLESINA, Caterina DOLLA, Roberta GIRAUDI & Luigi BIANCONE. (2023) Non-adherence assessment to immunosuppressant therapy with a self-report questionnaire and intra-patient variability in renal transplantation: risk factors and clinical correlations. Minerva Urology and Nephrology 75:1.
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Carmen Lefaucheur, Kevin Louis, Anna B. Morris, Jean-Luc Taupin, Peter Nickerson, Anat R. Tambur, Howard M. Gebel, Elaine F. Reed, Jon A. Kobashigawa, Anil Chandraker, Patricia P. Chang, Monica M. Colvin, Ramsey R. Hachem, Laurie D. Snyder, Stuart C. Sweet, Deborah J. Levine, Stuart J. Knechtle, Jacqueline G. O’Leary & Joshua Levitsky. (2023) Clinical recommendations for posttransplant assessment of anti–HLA (Human Leukocyte Antigen) donor-specific antibodies: A Sensitization in Transplantation: Assessment of Risk consensus document. American Journal of Transplantation 23:1, pages 115-132.
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Mercè Brunet & Marçal Pastor-Anglada. (2022) Insights into the Pharmacogenetics of Tacrolimus Pharmacokinetics and Pharmacodynamics. Pharmaceutics 14:9, pages 1755.
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Kevin Louis, Carmen Lefaucheur & Alexandre Loupy. (2022) Immunological Assessment and Monitoring in Kidney Transplantation. Nephrology Self-Assessment Program 21:3, pages 179-188.
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Aleixandra Mendoza Rojas, Dennis A. Hesselink, Nicole M. van Besouw, Marjolein Dieterich, Ronella de Kuiper, Carla C. Baan & Teun van Gelder. (2022) High Tacrolimus Intrapatient Variability and Subtherapeutic Immunosuppression are Associated With Adverse Kidney Transplant Outcomes. Therapeutic Drug Monitoring 44:3, pages 369-376.
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Maral Baghai Arassi, Laura Gauche, Jeremy Schmidt, Britta Höcker, Susanne Rieger, Caner Süsal, Burkhard Tönshoff & Alexander Fichtner. (2022) Association of intraindividual tacrolimus variability with de novo donor-specific HLA antibody development and allograft rejection in pediatric kidney transplant recipients with low immunological risk. Pediatric Nephrology.
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Lorena Santulario Verdú, Elena García-Romero & Carles Díez-López. (2022) Impacto clínico de la variabilidad en la concentración sanguínea de inhibidores de calcineurina en trasplante cardiaco: una espada de doble filo. Revista Española de Cardiología 75:2, pages 112-114.
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Lorena Santulario Verdú, Elena García-Romero & Carles Díez-López. (2022) Clinical impact of variability in blood concentrations of calcineurin inhibitors in heart transplant: a double-edged sword. Revista Española de Cardiología (English Edition) 75:2, pages 112-114.
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Khalil Karen, West-Thielke Patricia, Lichvar Alicia B, Benedetti Enrico, Okoroike Henry & Patel Shree. (2022) Time within therapeutic range: A comparison of three tacrolimus formulations in renal transplant recipients. Journal of Clinical Nephrology 6:1, pages 019-025.
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Nikola Stefanović, Radmila Veličković-Radovanović, Katarina Danković, Ivan Pavlović, Aleksandra Catić-Đorđević, Jelena Bašić, Milena Despotović, Tatjana Jevtović-Stoimenov, Branka Mitić & Tatjana Cvetković. (2021) Effect of the Interrelation between CYP3A5 Genotype, Concentration/Dose Ratio and Intrapatient Variability of Tacrolimus on Kidney Graft Function: Monte Carlo Simulation Approach. Pharmaceutics 13:11, pages 1970.
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Suwasin Udomkarnjananun, Marith I. Francke, Brenda C.M. De Winter, Midas B. Mulder, Carla C. Baan, Herold J. Metselaar, Caroline M. den Hoed & Dennis A. Hesselink. (2021) Therapeutic drug monitoring of immunosuppressive drugs in hepatology and gastroenterology. Best Practice & Research Clinical Gastroenterology 54-55, pages 101756.
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Janaína B. F. Everton, Fernando J. B. Patrício, Manuel S. Faria, Teresa C. A. Ferreira, Elen A. Romao, Gyl E. B. Silva & Marcelo Magalhães. (2021) CYP3A5 and PPARA genetic variants are associated with low trough concentration to dose ratio of tacrolimus in kidney transplant recipients. European Journal of Clinical Pharmacology 77:6, pages 879-886.
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Lauren Schumacher, Abbie D. Leino & Jeong M. Park. (2020) Tacrolimus intrapatient variability in solid organ transplantation: A multiorgan perspective. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 41:1, pages 103-118.
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Nikola Z. Stefanović, Radmila M. Veličković-Radovanović, Katarina S. Danković, Branka P. Mitić, Goran J. Paunović, Mina B. Cvetković & Tatjana P. Cvetković. (2020) Combined Effect of Inter- and Intrapatient Variability in Tacrolimus Exposure on Graft Impairment Within a 3-Year Period Following Kidney Transplantation: A Single-Center Experience. European Journal of Drug Metabolism and Pharmacokinetics 45:6, pages 749-760.
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Teun van Gelder, Soufian Meziyerh, Jesse J. Swen, Aiko P. J. de Vries & Dirk Jan A. R. Moes. (2020) The Clinical Impact of the C0/D Ratio and the CYP3A5 Genotype on Outcome in Tacrolimus Treated Kidney Transplant Recipients. Frontiers in Pharmacology 11.
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Charat Thongprayoon, Panupong Hansrivijit, Karthik Kovvuru, Swetha R. Kanduri, Tarun Bathini, Aleksandra Pivovarova, Justin R. Smith & Wisit Cheungpasitporn. (2020) Impacts of High Intra- and Inter-Individual Variability in Tacrolimus Pharmacokinetics and Fast Tacrolimus Metabolism on Outcomes of Solid Organ Transplant Recipients. Journal of Clinical Medicine 9:7, pages 2193.
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Rachel J. Tyson, Christine C. Park, J. Robert Powell, J. Herbert Patterson, Daniel Weiner, Paul B. Watkins & Daniel Gonzalez. (2020) Precision Dosing Priority Criteria: Drug, Disease, and Patient Population Variables. Frontiers in Pharmacology 11.
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