4,226
Views
25
CrossRef citations to date
0
Altmetric
Review

The role of IL-6 and IL-6 blockade in COVID-19

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Pages 601-618 | Received 24 Feb 2021, Accepted 15 Apr 2021, Published online: 27 May 2021

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Blanka Wolszczak-Biedrzycka, Justyna Dorf, Marzena Wojewódzka-Żelezniakowicz, Małgorzata Żendzian-Piotrowska, Violetta Joanna Dymicka-Piekarska, Joanna Matowicka-Karna & Mateusz Maciejczyk. (2023) Unveiling COVID-19 Secrets: Harnessing Cytokines as Powerful Biomarkers for Diagnosis and Predicting Severity. Journal of Inflammation Research 16, pages 6055-6070.
Read now
Bahareh Sadri, Atena Tamimi, Shirin Nouraein, Abolfazl Bagheri Fard, Javad Mohammadi, Mehdi Mohammadpour, Mohammad Hassanzadeh, Amir Bajouri, Hoda Madani, Maryam Barekat, Shahedeh Karimi Torshizi, Mahrooz Malek, Maede Ghorbani Liastani, Alireza Beheshti Maal, Maryam Niknejadi & Massoud Vosough. (2022) Clinical and laboratory findings following transplantation of allogeneic adipose-derived mesenchymal stromal cells in knee osteoarthritis, a brief report. Connective Tissue Research 63:6, pages 663-674.
Read now

Articles from other publishers (23)

Caroline Diorio, David T. Teachey & Scott W. Canna. (2023) Cytokine Storm Syndromes in Pediatric Patients. The Journal of Allergy and Clinical Immunology: In Practice 11:6, pages 1636-1644.
Crossref
Maria Peltola, Pabitra Basnyat, Suvi Liimatainen, Sirpa Rainesalo, Marko Pesu & Jukka Peltola. (2023) The Regulation of Plasma Interleukin-6 Levels Is Modified by Hippocampal Sclerosis and Its Lateralization in Drug-Resistant Temporal Lobe Epilepsy. Acta Neurologica Scandinavica 2023, pages 1-9.
Crossref
Lucrezia Mondini, Francesco Salton, Liliana Trotta, Chiara Bozzi, Riccardo Pozzan, Mariangela Barbieri, Stefano Tavano, Selene Lerda, Michael Hughes, Marco Confalonieri, Paola Confalonieri & Barbara Ruaro. (2023) Host-Based Treatments for Severe COVID-19. Current Issues in Molecular Biology 45:4, pages 3102-3121.
Crossref
Salma Said Zaki, Gamal El Sawaf, Asmaa AbelHameed Ahmed, Ayman Ibrahim Baess, Bassem Nashaat Beshey & Amel ELSheredy. (2023) Pattern of antibiotic use and bacterial co-infection in hospitalized Covid-19 patients. The Egyptian Journal of Bronchology 17:1.
Crossref
Renato Luís Pessôa, Gustavo da Rosa Abreu & Ramatis Birnfeld de Oliveira. (2023) MicroRNA Let-7 Plays an Important Role in the Immunopathology of COVID-19: A Systematic Review. Immuno 3:1, pages 112-121.
Crossref
Andrea T. Obi, Sriganesh B. Sharma, Megan A. Elfline, Catherine E. Luke, Abigail R. Dowling, Qing Cai, Andrew S. Kimball, Mike Hollinstat, Livia Stanger, Bethany B. Moore, Farouc A. Jaffer & Peter K. Henke. (2023) Experimental venous thrombus resolution is driven by IL-6 mediated monocyte actions. Scientific Reports 13:1.
Crossref
Judith M. Minkoff & Benjamin tenOever. (2023) Innate immune evasion strategies of SARS-CoV-2. Nature Reviews Microbiology.
Crossref
Jiayue He, Shuguang Liu, Qi Tan, Zhiying Liu, Jiewen Fu, Ting Li, Chunli Wei, Xiaoyan Liu, Zhiqiang Mei, Jingliang Cheng, Kai Wang & Junjiang Fu. (2022) Antiviral Potential of Small Molecules Cordycepin, Thymoquinone, and N6, N6-Dimethyladenosine Targeting SARS-CoV-2 Entry Protein ADAM17. Molecules 27:24, pages 9044.
Crossref
Mohammad Gholizadeh, Poorya Basafa Roodi, Faezeh Abaj, Sakineh Shab-Bidar, Ahmad Saedisomeolia, Omid Asbaghi & Mahshid lak. (2022) Influence of Vitamin A supplementation on inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials. Scientific Reports 12:1.
Crossref
Laura Beatriz Talarico, Analía Toledano, María Marta Contrini, Lidia E. Torrado, María Paula Martínez, María Isabel Gaillard, Ana Caratozzolo, Alana Brooke Byrne, Florencia Agustina Bonnin, María Soledad Tineo, Eduardo Walter Yfran, Patricio Leandro Acosta & Eduardo Luis López. (2022) Distinct Immune Phenotypes and Cytokine Profiles in Children with Differing Severity of COVID-19. Pediatric Infectious Disease Journal 41:11, pages 919-926.
Crossref
Nicola Potere, Marco Giuseppe Del Buono, Roberto Caricchio, Paul C. Cremer, Alessandra Vecchié, Ettore Porreca, Daniela Dalla Gasperina, Francesco Dentali, Antonio Abbate & Aldo Bonaventura. (2022) Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications. eBioMedicine 85, pages 104299.
Crossref
N. V. Iziurova, A. Yu. Savochkina, A. N. Uzunova & D. Yu. Nokhrin. (2022) Cytokine profile in community-acquired pneumonia in children. Medical Immunology (Russia) 24:5, pages 943-954.
Crossref
Sterre L. Siekman, Tamas Pongracz, Wenjun Wang, Jan Nouta, Peter G. Kremsner, Pedro Vieira da Silva-Neto, Meral Esen, Andrea Kreidenweiss, Jana Held, Átila Alexandre Trapé, Rolf Fendel, Isabel Kinney Ferreira de Miranda Santos & Manfred Wuhrer. (2022) The IgG glycome of SARS-CoV-2 infected individuals reflects disease course and severity. Frontiers in Immunology 13.
Crossref
Mengya Guo, Liwen Zhang, Jiaxin Ye, Xiao He, Pan Cao, Zicheng Zhou & Xiaodan Liu. (2022) Characterization of the pathogenesis and immune response to a highly virulent Edwardsiella tarda strain responsible for mass mortality in the hybrid snakehead (Channa maculate ♀ × Channa argus ♂). Microbial Pathogenesis 170, pages 105689.
Crossref
Ying-Shuang Li, Hua-Cheng Ren & Jian-Hua Cao. (2022) Roles of Interleukin-6-mediated immunometabolic reprogramming in COVID-19 and other viral infection-associated diseases. International Immunopharmacology 110, pages 109005.
Crossref
Yujie Jiang, Tingmei Zhao, Xueyan Zhou, Yu Xiang, Pedro Gutierrez‐Castrellon & Xuelei Ma. (2022) Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions. MedComm 3:3.
Crossref
Gustavo Ramírez-Martínez, Luis Armando Jiménez-ÁlvarezAlfredo Cruz-LagunasSergio Ignacio-CortésItzel Alejandra Gómez-GarcíaTatiana Sofia Rodríguez-ReynaJosé Alberto Choreño-Parra & Joaquín Zúñiga. (2022) Possible Role of Matrix Metalloproteinases and TGF-β in COVID-19 Severity and Sequelae. Journal of Interferon & Cytokine Research 42:8, pages 352-368.
Crossref
Xue Li, Ziqi Zhang, Zhenling Wang, Pedro Gutiérrez-Castrellón & Huashan Shi. (2022) Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19. Signal Transduction and Targeted Therapy 7:1.
Crossref
Guyi Wang, Bing Xiao, Jiayi Deng, Linmei Gong, Yi Li, Jinxiu Li & Yanjun Zhong. (2022) The Role of Cytochrome P450 Enzymes in COVID-19 Pathogenesis and Therapy. Frontiers in Pharmacology 13.
Crossref
Yuri Isaka, Yasutaka Hirasawa, Jiro Terada, Yu Shionoya, Yuichiro Takeshita, Toru Kinouchi, Ken Koshikawa, Hiroshi Tajima, Taku Kinoshita, Yuji Tada, Koichiro Tatsumi & Kenji Tsushima. (2022) Preliminary study regarding the predicted body weight-based dexamethasone therapy in patients with COVID-19 pneumonia. Pulmonary Pharmacology & Therapeutics 72, pages 102108.
Crossref
Bahareh Hafezi, Lily Chan, Jason P. Knapp, Negar Karimi, Kimia Alizadeh, Yeganeh Mehrani, Byram W. Bridle & Khalil Karimi. (2021) Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast Cells. Cells 10:7, pages 1761.
Crossref
Ali A. Rabaan, Shamsah H. Al-Ahmed, Mohammed A. Garout, Ayman M. Al-Qaaneh, Anupam A Sule, Raghavendra Tirupathi, Abbas Al Mutair, Saad Alhumaid, Abdulkarim Hasan, Manish Dhawan, Ruchi Tiwari, Khan Sharun, Ranjan K. Mohapatra, Saikat Mitra, Talha Bin Emran, Muhammad Bilal, Rajendra Singh, Salem A. Alyami, Mohammad Ali Moni & Kuldeep Dhama. (2021) Diverse Immunological Factors Influencing Pathogenesis in Patients with COVID-19: A Review on Viral Dissemination, Immunotherapeutic Options to Counter Cytokine Storm and Inflammatory Responses. Pathogens 10:5, pages 565.
Crossref
Richard McKendry, Nana-Marie Lemm, Loukas Papargyris & Christopher Chiu. 2021.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.