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Original Articles

Low sensitivity of a-defensin (Synovasure) test for intra­operative exclusion of prosthetic joint infection

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Pages 357-359 | Received 19 Dec 2017, Accepted 16 Jan 2018, Published online: 06 Mar 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Eric Senneville, Olivier Robineau, Caroline Loiez, Benoit de Saint Vincent, Julien Dartus & Henri Migaud. (2020) A profile on the Synovasure alpha defensin test for the detection of periprosthetic infections. Expert Review of Molecular Diagnostics 20:9, pages 895-904.
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Atsushi Narita, Akemi Suzuki, Taku Nakajima, Yuya Takakubo, Juji Ito, Akiko Sasaki & Michiaki Takagi. (2020) Assessing an alpha-defensin lateral flow device for diagnosing septic arthritis: reporting on a false-negative case and a false-positive case. Modern Rheumatology Case Reports 4:1, pages 156-160.
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Articles from other publishers (15)

A Felstead, P Kundasamy, G Penfold, K Whiting, J Buck, S Sturridge & M Meda. (2022) The combined measurement of synovial markers in the diagnosis of periprosthetic joint infection. The Annals of The Royal College of Surgeons of England 104:5, pages 334-339.
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Annemarie Goud, Don Nützinger, Akke van der Bij, Kevin Jenniskens, Joel Groenewold, Arthur de Gast & Joris E.J. Bekkers. (2022) Synovial-Based Tests Outperform Serum Markers to Rule Out Infection in Total Knee Arthroplasty and Total Hip Arthroplasty: A Systematic Review and Meta-Analysis. The Journal of Arthroplasty 37:4, pages 802-808.e5.
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Lucy C Walker, Nick D Clement, Munawar Hashmi, Stephen Green, Lee Longstaff & David J Deehan. (2021) The alpha defensin lateral flow test is effective in predicting eradication of periprosthetic joint infection after surgical debridement. Acta Orthopaedica Belgica 87:3, pages 563-569.
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Michael D. Ries. (2021) CORR Insights®: Plasma D-dimer Does Not Anticipate the Fate of Reimplantation in Two-stage Exchange Arthroplasty for Periprosthetic Joint Infection: A Preliminary Investigation. Clinical Orthopaedics & Related Research 479:7, pages 1469-1470.
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Yu‐qing Zeng, Shu Deng, Xing‐yang Zhu, Xiao‐bo Sun, Wen‐jun Feng, Jian‐chun Zeng, Hai‐tao Zhang & Yi‐rong Zeng. (2021) Diagnostic Accuracy of the Synovial Fluid α‐Defensin Lateral Flow Test in Periprosthetic Joint Infection: A Meta‐analysis. Orthopaedic Surgery 13:3, pages 708-718.
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Carl Deirmengian, John Madigan, Sujith Kallur Mallikarjuna, Janet Conway, Carlos Higuera & Robin Patel. (2021) Validation of the Alpha Defensin Lateral Flow Test for Periprosthetic Joint Infection. Journal of Bone and Joint Surgery 103:2, pages 115-122.
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J. LOUDA, P. KUBÁT & J. PILNÝ. (2020) Complications after Revision Total Knee Arthroplasties. Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca 87:1, pages 28-31.
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Ellis BernsCaitlin BarrettMursal GardeziCarole SpakeJillian GlasserValentin AntociChristopher T. BornDioscaris R. Garcia. (2020) Current Clinical Methods for Detection of Peri-Prosthetic Joint Infection. Surgical Infections 21:8, pages 645-653.
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Andrea Petrucca, Iolanda Santino, Giovanna Gentile, Daniele Mazza, Edoardo Viglietta, Raffaele Iorio, Maurizio Simmaco, Andrea Ferretti & Marina Borro. (2020) Detection of α‐defensin in synovial fluids by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry as an innovative and cost‐effective assay for improved definition of periprosthetic joint infections. Rapid Communications in Mass Spectrometry 34:11.
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Jesse W. P. Kuiper, Steven J. Verberne, Stan J. Vos & Pim W. van Egmond. (2020) Does the Alpha Defensin ELISA Test Perform Better Than the Alpha Defensin Lateral Flow Test for PJI Diagnosis? A Systematic Review and Meta-analysis of Prospective Studies. Clinical Orthopaedics & Related Research 478:6, pages 1333-1344.
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Jesse WP Kuiper, Pieter Pander & Stan J Vos. (2020) Good accuracy of the alpha-defensin lateral flow test for hip periprosthetic joint infection: A pilot study in a retrospective cohort of 52 patients. World Journal of Orthopedics 11:1, pages 236-46.
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Pavel Melicherčík, Eva Klapková, Karel Kotaška, David Jahoda, Ivan Landor & Václav Čeřovský. (2020) High-Performance Liquid Chromatography as a Novel Method for the Determination of α-Defensins in Synovial Fluid for Diagnosis of Orthopedic Infections. Diagnostics 10:1, pages 33.
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Yisheng Chen, Xueran Kang, Jie Tao, Yunpeng Zhang, Chenting Ying & Weiwei Lin. (2019) Reliability of synovial fluid alpha-defensin and leukocyte esterase in diagnosing periprosthetic joint infection (PJI): a systematic review and meta-analysis. Journal of Orthopaedic Surgery and Research 14:1.
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Xuequan Han, Kai Xie, Xu Jiang, Liao Wang, Haishan Wu, Xinhua Qu & Mengning Yan. (2019) Synovial fluid α-defensin in the diagnosis of periprosthetic joint infection: the lateral flow test is an effective intraoperative detection method. Journal of Orthopaedic Surgery and Research 14:1.
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Raju Vaishya, Raman Sardana, Hena Butta & Leena Mendiratta. (2019) Laboratory diagnosis of Prosthetic Joint Infections: Current concepts and present status. Journal of Clinical Orthopaedics and Trauma 10:3, pages 560-565.
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