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Acta Orthopaedica Volume 89, 2018 - Issue 6

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Vancomycin concentrations in the cervical spine after intravenous administration: results from an experimental pig study

Mats BueDepartment of Orthopaedic Surgery, Horsens Regional Hospital, Horsens; ;Orthopaedic Research Unit, Aarhus University Hospital, Aarhus; Correspondence[email protected]

Pelle HanbergDepartment of Orthopaedic Surgery, Horsens Regional Hospital, Horsens; ;Orthopaedic Research Unit, Aarhus University Hospital, Aarhus;

Mikkel TøttrupDepartment of Orthopaedic Surgery, Randers Regional Hospital, Randers; ;Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus;

Maja B ThomassenOrthopaedic Research Unit, Aarhus University Hospital, Aarhus;

Hanne Birke-SørensenOrthopaedic Research Unit, Aarhus University Hospital, Aarhus;

Theis M ThillemannOrthopaedic Research Unit, Aarhus University Hospital, Aarhus; ;Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus;

Torben L AnderssonDepartment of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark

Kjeld SøballeOrthopaedic Research Unit, Aarhus University Hospital, Aarhus; ;Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus;

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Pages 683-688 | Published online: 06 Aug 2018

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https://doi.org/10.1080/17453674.2018.1501548
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Josefine Slater, Maiken Stilling, Pelle Hanberg, Sofus Vittrup, Martin Bruun Knudsen, Sara Kousgaard Tøstesen, Josephine Olsen Kipp & Mats Bue. (2023) Concentrations of Co-Administered Meropenem and Vancomycin in Spinal Tissues Relevant for the Treatment of Pyogenic Spondylodiscitis—An Experimental Microdialysis Study. Antibiotics 12:5, pages 907.
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Johanne Gade Lilleøre, Sofus Vittrup, Sara Kousgaard Tøstesen, Pelle Hanberg, Maiken Stilling & Mats Bue. (2023) Comparison of Intravenous Microdialysis and Standard Plasma Sampling for Monitoring of Vancomycin and Meropenem Plasma Concentrations—An Experimental Porcine Study. Antibiotics 12:4, pages 791.
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Sofus Vittrup, Maiken Stilling, Pelle Hanberg, Sara Kousgaard Tøstesen, Martin Bruun Knudsen, Josephine Olsen Kipp & Mats Bue. (2022) Concentrations of co-administered vancomycin and meropenem in the internal dead space of a cannulated screw and in cancellous bone adjacent to the screw – Evaluated by microdialysis in a porcine model. Injury 53:8, pages 2734-2740.
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Elisabeth Krogsgaard Petersen, Pelle Hanberg, Martin Knudsen, Sara Kousgaard Tøstesen, Andrea René Jørgensen, Kristina Öbrink-Hansen, Kjeld Søballe, Maiken Stilling & Mats Bue. (2022) Intermittent Short-Term Infusion vs. Continuous Infusion of Piperacillin: Steady State Concentrations in Porcine Cervical Spine Tissue Evaluated by Microdialysis. Antibiotics 11:7, pages 910.
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Mathias A. F. Bendtsen, Pelle Hanberg, Josefine Slater, Jakob Hansen, Kristina Öbrink-Hansen, Maiken Stilling & Mats Bue. (2022) Steady-state concentrations of flucloxacillin in porcine vertebral cancellous bone and intervertebral disc following oral and intravenous administration assessed by microdialysis. European Spine Journal 31:6, pages 1508-1514.
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Sofus Ørbæk Vittrup, Pelle Hanberg, Martin Bruun Knudsen, Sara Kousgaard Tøstesen, Josephine Olsen Kipp, Jakob Hansen, Nis Pedersen Jørgensen, Maiken Stilling & Mats Bue. (2022) Tibial bone and soft-tissue concentrations following combination therapy with vancomycin and meropenem – evaluated by microdialysis in a porcine model. Bone & Joint Research 11:2, pages 112-120.
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Scott Marston, Gudrun Mirick Mueller, Arick Sabin, Glen T. Hansen, Bruce Lindgren, Conrado Aparicio, Alexandra R. Armstrong, Ole H. Larsen, Andrew Schmidt, Richard Kyle, Ramon Gustilo, Dean Tsukayama, Joan Bechtold & Mats Bue. (2021) Systemic versus free antibiotic delivery in preventing acute exogenous implant related infection in a rat model. Journal of Orthopaedic Research 40:2, pages 429-438.
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Mats Bue, Maja B. Thomassen, Ole H. Larsen, Andrea R. Jørgensen, Maiken Stilling, Kjeld Søballe & Pelle Hanberg. (2019) Local Vancomycin Concentrations after Intra-articular Injection into the Knee Joint: An Experimental Porcine Study. The Journal of Knee Surgery 34:09, pages 936-940.
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Mathias A. F. Bendtsen, Mats Bue, Pelle Hanberg, Josefine Slater, Maja B. Thomassen, Jakob Hansen, Kjeld Søballe, Kristina Öbrink-Hansen & Maiken Stilling. (2021) Flucloxacillin bone and soft tissue concentrations assessed by microdialysis in pigs after intravenous and oral administration. Bone & Joint Research 10:1, pages 60-67.
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Pelle Hanberg, Mats Bue, Kristina Öbrink-Hansen, Maja Thomassen, Kjeld Søballe & Maiken Stilling. (2020) Timing of Antimicrobial Prophylaxis and Tourniquet Inflation. Journal of Bone and Joint Surgery 102:21, pages 1857-1864.
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Pelle Hanberg, Mats Bue, Andrea René Jørgensen, Maja Thomassen, Kristina Öbrink-Hansen, Kjeld Søballe & Maiken Stilling. (2020) Pharmacokinetics of double-dose cefuroxime in porcine intervertebral disc and vertebral cancellous bone—a randomized microdialysis study. The Spine Journal 20:8, pages 1327-1332.
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Maja B. Thomassen, Pelle Hanberg, Maiken Stilling, Klaus K. Petersen, Kjeld Søballe, Lasse B. Krag, Carsten S. Højskov & Mats Bue. (2020) Local concentrations of gentamicin obtained by microdialysis after a controlled application of a GentaColl sponge in a porcine model. Journal of Orthopaedic Research 38:8, pages 1793-1799.
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Melissa Brooks Peterson, Mindy N. Cohen, Brent R. O’Neill, Sumeet Garg, Jason Child, Thomas K. HenthornJeffrey G. Galinkin. (2020) Preoperative Vancomycin Administration for Surgical Site Prophylaxis: Plasma and Soft-Tissue Concentrations in Pediatric Neurosurgical and Orthopedic Patients. Anesthesia & Analgesia 130:5, pages 1435-1444.
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Marianna A. Tryfonidou, Geert de Vries, Wim E. Hennink & Laura B. Creemers. (2020) “Old Drugs, New Tricks” – Local controlled drug release systems for treatment of degenerative joint disease. Advanced Drug Delivery Reviews 160, pages 170-185.
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Pelle Hanberg, Andrea Lund, Kjeld Søballe & Mats Bue. (2019) Single-dose pharmacokinetics of meropenem in porcine cancellous bone determined by microdialysis. Bone & Joint Research 8:7, pages 342-348.
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Vancomycin concentrations in the cervical spine after intravenous administration: results from an experimental pig study

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Vancomycin concentrations in the cervical spine after intravenous administration: results from an experimental pig study

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