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Expert Opinion on Drug Discovery Volume 12, 2017 - Issue 9
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Review

Approaches for discovering novel bioactive small molecules targeting autophagy

Hui-yun HwangChemical Genomics Global Research Laboratory, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of KoreaView further author information
,
Sung Min ChoChemical Genomics Global Research Laboratory, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of KoreaView further author information
&
Ho Jeong KwonChemical Genomics Global Research Laboratory, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of KoreaCorrespondence[email protected]
View further author information
Pages 909-923 | Received 28 Mar 2017, Accepted 28 Jun 2017, Published online: 30 Jul 2017

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Hui-Yun Hwang, Joong Sup Shim, Dasol Kim & Ho Jeong Kwon. (2021) Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy 17:10, pages 2783-2799.
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Dasol Kim, Hui-Yun Hwang & Ho Jeong Kwon. (2020) Targeting Autophagy In Disease: Recent Advances In Drug Discovery. Expert Opinion on Drug Discovery 15:9, pages 1045-1063.
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Sha Yang, Zhuyang Zhao, Binpan Wang, Liu Feng, Jie Luo, Ruijia Deng, Jing Sheng, Xueping Gao, Shuang Xie, Ming Chen & Kai Chang. (2023) Modular Engineering of a DNA Tetrahedron-Based Nanomachine for Ultrasensitive Detection of Intracellular Bioactive Small Molecules. ACS Applied Materials & Interfaces 15:19, pages 23662-23670.
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Sandeep Vellanki, Alexis E. Garcia & Soo Chan Lee. (2020) Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens. Frontiers in Molecular Biosciences 7.
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Hui‐Yun Hwang, Tae Young Kim, Marcell A. Szász, Balazs Dome, Johan Malm, Gyorgy Marko‐Varga & Ho Jeong Kwon. (2020) Profiling the Protein Targets of Unmodified Bio‐Active Molecules with Drug Affinity Responsive Target Stability and Liquid Chromatography/Tandem Mass Spectrometry. PROTEOMICS 20:9, pages 1900325.
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Hui-Yun Hwang, Yoon Sun Cho, Jin Young Kim, Ki Na Yun, Jong Shin Yoo, Eunhyeong Lee, Injune Kim & Ho Jeong Kwon. (2020) Autophagic Inhibition via Lysosomal Integrity Dysfunction Leads to Antitumor Activity in Glioma Treatment. Cancers 12:3, pages 543.
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T. A. Korolenko, A. B. Shintyapina, A. B. Pupyshev, A. A. Akopyan, G. S. Russkikh, M. A. Dikovskaya, V. A. Vavilin, E. L Zavjalov, M. A. Tikhonova & T. G. Amstislavskaya. (2019) The regulatory role of cystatin C in autophagy and neurodegeneration. Vavilov Journal of Genetics and Breeding 23:4, pages 390-397.
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Jiraporn Paha, Phongthon Kanjanasirirat, Bamroong Munyoo, Patoomratana Tuchinda, Naravut Suvannang, Chanin Nantasenamat, Kanokthip Boonyarattanakalin, Prasat Kittakoop, Sirawit Srikor, Gunganist Kongklad, Noppawan Rangkasenee, Suradej Hongeng, Pongsak Utaisincharoen, Suparerk Borwornpinyo & Marisa Ponpuak. (2019) A novel potent autophagy inhibitor ECDD-S27 targets vacuolar ATPase and inhibits cancer cell survival. Scientific Reports 9:1.
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Kyeong-A KimDonggeun ShinJeong-Hyeon KimYoung-Jun ShinG.K. RajanikantArshad MajidSeung-Hoon BaekOk-Nam Bae. (2018) Role of Autophagy in Endothelial Damage and Blood–Brain Barrier Disruption in Ischemic Stroke. Stroke 49:6, pages 1571-1579.
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