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Review

Discovery methods of coagulation-inhibiting drugs

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Pages 1195-1205 | Received 02 Aug 2017, Accepted 22 Sep 2017, Published online: 27 Sep 2017

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Shuanzhi Wu, Tenghua Wang, Jieyun Li, Zhixin Zhang, Chen Li, Shuangshuang Xiao, Jin He, Xuan Wang, Zhiqin Hu, Xiaole Wang, Sichao Zheng, Xintong Liang, Guiying Chen, Yongmei Li, Xianbo Li, Yaoxuan Zhan, Qinwen Zou, Hongliang Jiang, Qingshan Zheng, Li Ban, Haiyan Liu & Yi Fang. (2023) First-in-human trial of SAR107375E, a novel small molecule anticoagulant with dual inhibition of factor Xa and factor IIa. Expert Opinion on Investigational Drugs 32:11, pages 1085-1094.
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Zeyu Guan, Roxanna Wang, Rawaa H. Hussain, James C. Fredenburgh, Iqbal H. Jaffer & Jeffrey I. Weitz. (2023) Rivaroxaban and apixaban are less effective than enoxaparin for the prevention of catheter-induced clotting in vitro. Journal of Thrombosis and Haemostasis 21:1, pages 76-82.
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Omri Cohen & Walter Ageno. (2022) Coming soon to a pharmacy near you? FXI and FXII inhibitors to prevent or treat thromboembolism. Hematology 2022:1, pages 495-505.
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Tingting Ma, Yanli Dong, Lei Huang, Yuanxun Yang, Yan Geng, Fei Fei, Pinhao Xie, Yu Zhao, Hui Lin, Zeyu Yang, Yun Jin, Xitong Ju, Runbin Sun & Juan Li. (2022) SHR2285, the first selectively oral FXIa inhibitor in China: Safety, tolerability, pharmacokinetics and pharmacodynamics combined with aspirin, clopidogrel or ticagrelor. Frontiers in Pharmacology 13.
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Nayeon Kim, CheLynn Jeon, Chaeyeong Kim, Soo Ho Ryu, Wonhwa Lee & Jong-Sup Bae. (2022) Inhibition of factor Xa activity, platelet aggregation, and experimentally induced thrombosis by Sparstolonin B. Phytomedicine 99, pages 153987.
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Ningning Yao, Zhiping Jia, Yongbin Tian, Shuzeng Hou, Xiaoxiao Yang, Jihong Han, Yajun Duan, Chenzhong Liao, Yi Kong & Zhouling Xie. (2022) Targeting the S2 Subsite Enables the Structure-Based Discovery of Novel Highly Selective Factor XIa Inhibitors. Journal of Medicinal Chemistry 65:5, pages 4318-4334.
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Yu Lei, Bing Zhang, Yan Zhang, Xiwen Dai, Yulin Duan, Qing Mao, Jun Gao, Yuwei Yang, Ziyang Bao, Xuefeng Fu, Kunqi Ping, Chengda Yan, Yanhua Mou & Shaojie Wang. (2021) Design, synthesis and biological evaluation of novel FXIa inhibitors with 2-phenyl-1H-imidazole-5-carboxamide moiety as P1 fragment. European Journal of Medicinal Chemistry 220, pages 113437.
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Yubin Liu, Meixia Wang, Xiaona Dong, Jia He, Lin Zhang, Ying Zhou, Xia Xia, Guifang Dou, Chu‐tse Wu & Jide Jin. (2021) A phase I, single and continuous dose administration study on the safety, tolerability, and pharmacokinetics of neorudin, a novel recombinant anticoagulant protein, in healthy subjects. Pharmacology Research & Perspectives 9:3.
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Kyung‐Min Kim, Jaehong Kim, Moon‐Chang Baek & Jong‐Sup Bae. (2020) Novel factor Xa inhibitor, maslinic acid, with antiplatelet aggregation activity. Journal of Cellular Physiology 235:12, pages 9445-9456.
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Nigel Mackman, Wolfgang Bergmeier, George A. Stouffer & Jeffrey I. Weitz. (2020) Therapeutic strategies for thrombosis: new targets and approaches. Nature Reviews Drug Discovery 19:5, pages 333-352.
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Kenneth A. Bauer. (2020) How Effective and Safe Is Factor XI Inhibition in Preventing Venous Thrombosis?. JAMA 323:2, pages 121.
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Masahiro IEKO, Kazuki KIYOHARA, Akihiro OTSU & Kenji SHIMOSEGAWA. (2020) Current status of anticoagulant therapy and development of coagulation factor XI(a) inhibitors抗凝固療法の現状と凝固第XI(a)因子阻害薬の開発状況. Japanese Journal of Thrombosis and Hemostasis 31:6, pages 619-623.
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Suzanne Murray, Claire McLintock, Patrice Lazure, Morgan Peniuta, Sam Schulman, Suely M. Rezende, James H. Morrissey, Thomas Reiser & Ingrid Pabinger. (2019) Needs and challenges among physicians and researchers in thrombosis and hemostasis: Results from an international study. Research and Practice in Thrombosis and Haemostasis 3:4, pages 626-638.
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Benjamin F. Tillman, Andras Gruber, Owen J.T. McCarty & David Gailani. (2018) Plasma contact factors as therapeutic targets. Blood Reviews 32:6, pages 433-448.
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