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Expert Opinion on Drug Discovery Volume 14, 2019 - Issue 9
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Review

Contemporary medicinal-chemistry strategies for discovery of blood coagulation factor Xa inhibitors

Xia HaoDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji’nan, Shandong, PR ChinaView further author information
,
Xiaofang ZuoDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji’nan, Shandong, PR ChinaView further author information
,
Dongwei KangDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji’nan, Shandong, PR ChinaView further author information
,
Jian ZhangDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji’nan, Shandong, PR ChinaView further author information
,
Yuning SongDepartment of Clinical Pharmacy, Qilu Hospital of Shandong University, Jinan, ChinaView further author information
,
Xinyong LiuDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji’nan, Shandong, PR ChinaCorrespondence[email protected]
View further author information
&
Peng ZhanDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji’nan, Shandong, PR ChinaCorrespondence[email protected]
View further author information
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Pages 915-931 | Received 23 Nov 2018, Accepted 30 May 2019, Published online: 07 Jun 2019

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Haijia Lu, Yongqi Wu, Hongyi Zhao & Dongfeng Zhang. (2022) Design and synthesis of tricyclic benzo[1, 3]oxazinyloxazolidinones as blood coagulation factor Xa inhibitors. Synthetic Communications 52:8, pages 1198-1207.
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Atul N. Khadse, Hardik H. Savsani, Rupesh V. Chikhale, Rahul B. Ghuge, Dixit R. Prajapati, Goshiya Kureshi, Prashant R. Murumkar, Kirti V. Patel, Sadhana J. Rajput & Mange Ram Yadav. (2022) Design, synthesis and biological evaluation of Piperazinylanthranilamides as potential factor Xa inhibitors. Journal of Molecular Structure 1270, pages 133974.
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María Isabel Fernández-Bachiller, Songhwan Hwang, María Elena Schembri, Peter Lindemann, Mónica Guberman, Svenja Herziger, Edgar Specker, Hans Matter, David W. Will, Jörg Czech, Michael Wagner, Armin Bauer, Herman Schreuder, Kurt Ritter, Matthias Urmann, Volkmar Wehner, Han Sun & Marc Nazaré. (2022) Probing Factor Xa Protein–Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands. Journal of Medicinal Chemistry 65:19, pages 13013-13028.
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Hossein Hosseinzadeh & Marjan Nassiri-Asl. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 605 633 .
Sibsankar Kundu & Sangwook Wu. (2021) A Structure Based Study of Selective Inhibition of Factor IXa over Factor Xa. Molecules 26:17, pages 5372.
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Shuo Yuan, Bin Yu & Hong-Min Liu. (2020) New drug approvals for 2019: Synthesis and clinical applications. European Journal of Medicinal Chemistry 205, pages 112667.
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