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Review

Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement?

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Pages 995-1035 | Received 18 Apr 2019, Accepted 25 Jun 2019, Published online: 03 Jul 2019

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Bijo Mathew, Veerasamy Ravichandran, Seenivasan Raghuraman, T. M. Rangarajan, Mohamed A. Abdelgawad, Iqrar Ahmad, Harun M. Patel & Hoon Kim. (2023) Two dimensional-QSAR and molecular dynamics studies of a selected class of aldoxime- and hydroxy-functionalized chalcones as monoamine oxidase-B inhibitors. Journal of Biomolecular Structure and Dynamics 41:19, pages 9256-9266.
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Paolo Guglielmi, Simone Carradori, Ilaria D’Agostino, Cristina Campestre & Jacobus P. Petzer. (2022) An updated patent review on monoamine oxidase (MAO) inhibitors. Expert Opinion on Therapeutic Patents 32:8, pages 849-883.
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Fisayo A. Olotu, Monu Joy, Mohamed A. Abdelgawad, Siju E. Narayanan, Mahmoud E. Soliman & Bijo Mathew. (2021) Revealing the role of fluorine pharmacophore in chalcone scaffold for shifting the MAO-B selectivity: investigation of a detailed molecular dynamics and quantum chemical study. Journal of Biomolecular Structure and Dynamics 39:16, pages 6126-6139.
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Paolo Guglielmi, Daniela Secci, Anél Petzer, Donatella Bagetta, Paola Chimenti, Giulia Rotondi, Claudio Ferrante, Lucia Recinella, Sheila Leone, Stefano Alcaro, Gokhan Zengin, Jacobus P. Petzer, Francesco Ortuso & Simone Carradori. (2019) Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1511-1525.
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Yangjing Lv, Zhiyuan Zheng, Renzheng Liu, Jianan Guo, Changjun Zhang & Yuanyuan Xie. (2023) Monoamine oxidase B inhibitors based on natural privileged scaffolds: A review of systematically structural modification. International Journal of Biological Macromolecules 251, pages 126158.
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