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Expert Opinion on Drug Discovery Volume 15, 2020 - Issue 3: Women in Drug Discovery
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Review

Recent progress and challenges in drug development to fight hand, foot and mouth disease

Ze Qin LimDepartment of Microbiology&Immunology, Yong Loo Lin School of Medicine, Immunology program, Life Sciences Institute, National University of Singapore, Singapore, SingaporeView further author information
,
Qing Yong NgDepartment of Microbiology&Immunology, Yong Loo Lin School of Medicine, Immunology program, Life Sciences Institute, National University of Singapore, Singapore, SingaporeView further author information
,
Justin Wei Qing NgDepartment of Microbiology&Immunology, Yong Loo Lin School of Medicine, Immunology program, Life Sciences Institute, National University of Singapore, Singapore, SingaporeView further author information
,
Vikneswari MahendranDepartment of Microbiology&Immunology, Yong Loo Lin School of Medicine, Immunology program, Life Sciences Institute, National University of Singapore, Singapore, SingaporeView further author information
&
Sylvie AlonsoDepartment of Microbiology&Immunology, Yong Loo Lin School of Medicine, Immunology program, Life Sciences Institute, National University of Singapore, Singapore, SingaporeCorrespondence[email protected]
View further author information
Pages 359-371 | Received 31 May 2019, Accepted 20 Aug 2019, Published online: 30 Aug 2019

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Chih-Yeu Fang & Chia-Chyi Liu. (2022) Novel strategies for the development of hand, foot, and mouth disease vaccines and antiviral therapies. Expert Opinion on Drug Discovery 17:1, pages 27-39.
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Han Kang Tee, Mohd Izwan Zainol, I-Ching Sam & Yoke Fun Chan. (2021) Recent advances in the understanding of enterovirus A71 infection: a focus on neuropathogenesis. Expert Review of Anti-infective Therapy 19:6, pages 733-747.
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Xinhui Wang, Zhilin Hu, Wei Zhang, Shuwei Wu, Yongjin Hao, Xia Xiao, Jingjing Li, Xiaoliang Yu, Chengkui Yang, Jingfeng Wang, Huiying Zhang, Feng Ma, Weifeng Shi, Jianwei Wang, Xiaobo Lei, Xiaohu Zhang & Sudan He. (2023) Inhibition of lysosome-tethered Ragulator-Rag-3D complex restricts the replication of Enterovirus 71 and Coxsackie A16. Journal of Cell Biology 222:12.
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Yuwei Liu, Yuan Xi, Likai Ji, Quan Shen, Wen Zhang & Mengzhu Xue. (2023) Antiviral Drugs (Synthetic Small Molecule Inhibitors and Nature Drugs) Against EV71 in Enteroviruses: Advances and Perspectives. Clinical Complementary Medicine and Pharmacology 3:4, pages 100099.
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Wenbing Zhu, Jun Li, Zhongxiang Wu, Hui Li, Zhixiao Zhang, Xiaoyong Zhu, Ming Sun & Shaozhong Dong. (2023) Dual blockages of a broad and potent neutralizing IgM antibody targeting GH loop of EV‐As . Immunology 169:3, pages 292-308.
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Zijie Li, Wangquan Ji, Shuaiyin Chen, Guangcai Duan & Yuefei Jin. (2023) Hand, Foot, and Mouth Disease Challenges and Its Antiviral Therapeutics. Vaccines 11:3, pages 571.
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Wangquan Ji, Tiantian Sun, Dong Li, Shuaiyin Chen, Haiyan Yang, Yuefei Jin & Guangcai Duan. (2023) TBK1 and IRF3 are potential therapeutic targets in Enterovirus A71-associated diseases. PLOS Neglected Tropical Diseases 17:1, pages e0011001.
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Xiaolan Yuan, Ziwei Liu, Li Wan, Wei Liu, Yan Huang & Shuang Cao. (2023) Recent advances in anti-coxsackievirus A16 viral drug research. Future Medicinal Chemistry 15:1, pages 97-117.
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Huiqiang Wang, Boming Cui, Haiyan Yan, Shuo Wu, Kun Wang, Ge Yang, Jiandong Jiang & Yuhuan Li. (2023) Targeting 7-dehydrocholesterol reductase against EV-A71 replication by upregulating interferon response. Antiviral Research 209, pages 105497.
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Kevin Messacar, Matthew R. Vogt, Edwin J. Asturias & Mark J. Abzug. 2023. Plotkin's Vaccines. Plotkin's Vaccines 330 340.e5 .
Alexander K. C. Leung, Joseph M. Lam, Benjamin Barankin, Kin Fon Leong & Kam Lun Hon. (2022) Hand, Foot, and Mouth Disease: A Narrative Review. Recent Advances in Inflammation & Allergy Drug Discovery 16:2, pages 77-95.
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Huanxi Zhao, Wenbo Jiao, Yang Xiu, Kailu Zhou, Peng Zhong, Nan Wang & Shanshan Yu. (2022) Enzymatic Biotransformation of Gypenoside XLIX into Gylongiposide I and Their Antiviral Roles against Enterovirus 71 In Vitro. Molecules 27:13, pages 4094.
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Jun Wang, Yanmei Hu & Madeleine Zheng. (2022) Enterovirus A71 antivirals: Past, present, and future. Acta Pharmaceutica Sinica B 12:4, pages 1542-1566.
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Yanmei Hu, Naoya Kitamura, Rami Musharrafieh & Jun Wang. (2021) Discovery of Potent and Broad-Spectrum Pyrazolopyridine-Containing Antivirals against Enteroviruses D68, A71, and Coxsackievirus B3 by Targeting the Viral 2C Protein. Journal of Medicinal Chemistry 64:12, pages 8755-8774.
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Yanmei Hu, Rami Musharrafieh, Madeleine Zheng & Jun Wang. (2020) Enterovirus D68 Antivirals: Past, Present, and Future. ACS Infectious Diseases 6:7, pages 1572-1586.
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Yan Ding, Jie Xu, Liang-bin Cheng, Yong-qian Huang, You-qin Wang, Hui Li, Yu Li, Jing-yu Ji, Ji-hong Zhang & Lei Zhao. (2020) Effect of Emodin on Coxsackievirus B3m-Mediated Encephalitis in Hand, Foot, and Mouth Disease by Inhibiting Toll-Like Receptor 3 Pathway In Vitro and In Vivo. The Journal of Infectious Diseases 222:3, pages 443-455.
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