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Expert Opinion on Drug Discovery Volume 15, 2020 - Issue 10
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Review

Advances in the discovery and development of selective heme-displacing IDO1 inhibitors

Lijun SunCenter for Drug Discovery and Translational Research, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USACorrespondence[email protected]
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Pages 1223-1232 | Received 02 Feb 2020, Accepted 09 Jun 2020, Published online: 22 Jun 2020

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E Orecchini, ML Belladonna, MT Pallotta, C Volpi, L Zizi, E Panfili, M Gargaro, F Fallarino, S Rossini, C Suvieri, A Macchiarulo, S Bicciato, G Mondanelli & C Orabona. (2023) The signaling function of IDO1 incites the malignant progression of mouse B16 melanoma. OncoImmunology 12:1.
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Peng-Fei Wang, Li-Qiang Yang, Zhao-Hang Shi, Xue-Min Li & Han-Yue Qiu. (2022) An updated patent review of IDO1 inhibitors for cancer (2018–2022). Expert Opinion on Therapeutic Patents 32:11, pages 1145-1159.
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Articles from other publishers (6)

Zakia Akter, Narges Salamat, Md. Yousuf Ali & Li Zhang. (2023) The promise of targeting heme and mitochondrial respiration in normalizing tumor microenvironment and potentiating immunotherapy. Frontiers in Oncology 12.
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Maria Teresa Pallotta, Sofia Rossini, Chiara Suvieri, Alice Coletti, Ciriana Orabona, Antonio Macchiarulo, Claudia Volpi & Ursula Grohmann. (2021) Indoleamine 2,3‐dioxygenase 1 (IDO1): an up‐to‐date overview of an eclectic immunoregulatory enzyme. The FEBS Journal 289:20, pages 6099-6118.
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Pranjal Biswas, Yue Dai & Dennis J. Stuehr. (2022) Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through GAPDH- and Hsp90-dependent control of their heme levels. Free Radical Biology and Medicine 180, pages 179-190.
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Yunze Wu, Qizhu Duan, Yi Zou, Qihua Zhu & Yungen Xu. (2021) Discovery of novel IDO1 inhibitors targeting the protein’s apo form through scaffold hopping from holo-IDO1 inhibitor. Bioorganic & Medicinal Chemistry Letters 52, pages 128373.
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Shaymaa Emam Kassab & Samar Mowafy. (2021) Structural Basis of Selective Human Indoleamine‐2,3‐dioxygenase 1 (hIDO1) Inhibition. ChemMedChem 16:20, pages 3149-3164.
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Minah Kim & Petr Tomek. (2021) Tryptophan: A Rheostat of Cancer Immune Escape Mediated by Immunosuppressive Enzymes IDO1 and TDO. Frontiers in Immunology 12.
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