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Expert Review of Hematology Volume 10, 2017 - Issue 6
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Review

Heme-mediated cell activation: the inflammatory puzzle of sickle cell anemia

Caroline Conceição da GuardaLaboratório de Hematologia, Genética e Biologia Computacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador, Bahia, BrasilView further author information
,
Rayra Pereira SantiagoLaboratório de Hematologia, Genética e Biologia Computacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador, Bahia, BrasilView further author information
,
Luciana Magalhães FiuzaLaboratório de Hematologia, Genética e Biologia Computacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador, Bahia, BrasilView further author information
,
Milena Magalhães AleluiaLaboratório de Hematologia, Genética e Biologia Computacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador, Bahia, BrasilView further author information
,
Júnia Raquel Dutra FerreiraLaboratório de Hematologia, Genética e Biologia Computacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador, Bahia, Brasil;Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Bahia, BrasilView further author information
,
Camylla Vilas Boas FigueiredoLaboratório de Hematologia, Genética e Biologia Computacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador, Bahia, BrasilView further author information
,
Setondji Cocou Modeste Alexandre YahouedehouLaboratório de Hematologia, Genética e Biologia Computacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador, Bahia, BrasilView further author information
,
Rodrigo Mota de OliveiraFaculdade de Farmácia, Universidade Federal da Bahia, Salvador, Bahia, BrasilView further author information
,
Isa Menezes LyraHematologia, Fundação de Hematologia e Hemoterapia do Estado da Bahia, Salvador, Bahia, BrasilView further author information
&
Marilda de Souza GonçalvesLaboratório de Hematologia, Genética e Biologia Computacional, Instituto Gonçalo Moniz, FIOCRUZ, Salvador, Bahia, Brasil;Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Bahia, BrasilCorrespondence[email protected]
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Pages 533-541 | Received 03 Feb 2017, Accepted 04 May 2017, Published online: 17 May 2017

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Madhav Vissa, Sandra K Larkin, Elliott P Vichinsky, Frans A Kuypers & Eric Soupene. (2023) Assessment of total and unbound cell-free heme in plasma of patients with sickle cell disease. Experimental Biology and Medicine 248:10, pages 897-907.
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Rick A. Homan, Appaso M. Jadhav, Louis P. Conway & Christopher G. Parker. (2022) A Chemical Proteomic Map of Heme–Protein Interactions. Journal of the American Chemical Society 144:33, pages 15013-15019.
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D. A. Schreier, T. A. Hacker, D. M. Tabima, M. O. Platt & N. C. Chesler. (2020) Effects of Red Blood Cell Sickling on Right Ventricular Afterload in vivo. Experimental Mechanics.
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Rayra Pereira Santiago, Camylla Vilas Boas Figueiredo, Luciana Magalhães Fiuza, Sétondji Cocou Modeste Alexandre Yahouédéhou, Rodrigo Mota Oliveira, Milena Magalhães Aleluia, Suellen Pinheiro Carvalho, Cleverson Alves Fonseca, Valma Maria Lopes Nascimento, Larissa Carneiro Rocha, Caroline Conceição Guarda & Marilda Souza Gonçalves. (2020) TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia. Disease Markers 2020, pages 1-9.
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Gael F. P. BoriesScott Yeudall, Vlad Serbulea, Todd E. Fox, Brant E. Isakson & Norbert Leitinger. (2020) Macrophage metabolic adaptation to heme detoxification involves CO-dependent activation of the pentose phosphate pathway. Blood 136:13, pages 1535-1548.
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Xu Yang, Jun Liu, Meng-Meng Yang, Shao-Hong Wang, Li Xu, Shan Ke, Xue-Mei Ding, Wen-Bing Sun & Jun Gao. (2019) Heme is involved in the systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas. European Journal of Gastroenterology & Hepatology 32:9, pages 1200-1206.
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Caroline Conceição da Guarda, Sètondji Cocou Modeste Alexandre Yahouédéhou, Rayra Pereira Santiago, Camila Felix de Lima Fernandes, Joelma Santana dos Santos Neres, Antonio Mateus de Jesus Oliveira, Milena Magalhães Aleluia, Camylla Vilas Boas Figueiredo, Cleverson Alves Fonseca, Luciana Magalhães Fiuza, Suellen Pinheiro Carvalho, Rodrigo Mota de Oliveira, Valma Maria Lopes Nascimento, Larissa Carneiro Rocha & Marilda Souza Gonçalves. (2020) Investigation of Lipid Profile and Clinical Manifestations in SCA Children. Disease Markers 2020, pages 1-10.
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Mehdi Nouraie, Allison E. Ashley-Koch, Melanie E. Garrett, Nithya Sritharan, Yingze Zhang, Jane Little, Victor R. Gordeuk, Mark T. Gladwin, Marilyn J. Telen & Gregory J. Kato. (2020) Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts. PLOS ONE 15:8, pages e0237543.
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Caroline Conceição da Guarda, Sètondji Cocou Modeste Alexandre Yahouédéhou, Rayra Pereira Santiago, Joelma Santana dos Santos Neres, Camila Felix de Lima Fernandes, Milena Magalhães Aleluia, Camylla Vilas Boas Figueiredo, Luciana Magalhães Fiuza, Suellen Pinheiro Carvalho, Rodrigo Mota de Oliveira, Cleverson Alves Fonseca, Uche Samuel Ndidi, Valma Maria Lopes Nascimento, Larissa Carneiro Rocha & Marilda Souza Goncalves. (2020) Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC). PLOS ONE 15:1, pages e0228399.
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France Pirenne. (2019) The cause and pathogenesis of hemolytic transfusion reactions in sickle-cell disease. Current Opinion in Hematology 26:6, pages 488-494.
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Caroline C. Guarda, Paulo S. M. Silveira-Mattos, Sètondji C. M. A. Yahouédéhou, Rayra P. Santiago, Milena M. Aleluia, Camylla V. B. Figueiredo, Luciana M. Fiuza, Suellen P. Carvalho, Rodrigo M. Oliveira, Valma M. L. Nascimento, Nívea F. Luz, Valéria M. Borges, Bruno B. Andrade & Marilda S. Gonçalves. (2019) Hydroxyurea alters circulating monocyte subsets and dampens its inflammatory potential in sickle cell anemia patients. Scientific Reports 9:1.
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Cadiele Oliana Reichert, Carolina Garcia de Macedo, Débora Levy, Bruno Carnevale Sini, Andréia Moreira Monteiro, Magnus Gidlund, Luciana Morganti Ferreira Maselli, Sandra Fátima Menosi Gualandro & Sérgio Paulo Bydlowski. (2019) Paraoxonases (PON) 1, 2, and 3 Polymorphisms and PON-1 Activities in Patients with Sickle Cell Disease. Antioxidants 8:8, pages 252.
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Sandhya R. PanchCelina Montemayor-GarciaHarvey G. Klein. (2019) Hemolytic Transfusion Reactions. New England Journal of Medicine 381:2, pages 150-162.
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Sonny Michael Assennato, Shirley Owusu‐Ofori, Alex Osei‐Akoto, Nathalie C. Lambert & Jean‐Pierre Allain. (2018) Microchimerism in Ghanaian children recipients of whole blood transfusion for severe anaemia. Vox Sanguinis 114:2, pages 162-170.
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O. V. Kosmachevskaya & A. F. Topunov. (2019) Alternate and Additional Functions of Erythrocyte Hemoglobin. Biochemistry (Moscow) 83:12-13, pages 1575-1593.
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