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Are BTK and PLCG2 mutations necessary and sufficient for ibrutinib resistance in chronic lymphocytic leukemia?

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Pages 185-194 | Received 27 Nov 2017, Accepted 29 Jan 2018, Published online: 12 Feb 2018

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Paweł Robak, Magda Witkowska, Anna Wolska-Washer & Tadeusz Robak. (2023) The preclinical discovery and development of orelabrutinib as a novel treatment option for B-cell lymphoid malignancies. Expert Opinion on Drug Discovery 18:10, pages 1065-1076.
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Barina Aqil, Amandeep Kaur, Josean Ramos, Madina Sukhanova, Shuo Ma, Juehua Gao, Xinyan Lu, Yi-Hua Chen & Qing Chen. (2023) Richter transformation to aggressive plasmablastic neoplasm related to selection of a BTK-mutated clone in a patient with CLL/SLL treated by ibrutinib. Leukemia & Lymphoma 64:1, pages 242-245.
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Fortunato Morabito, Anna Grazia Recchia, Ernesto Vigna, Cirino Botta, Mamdouh Skafi, Mohammed Abu-Rayyan, Moien Atrash, Sara Galimberti, Lucio Morabito, Hamdi Al-Janazreh, Massimo Martino, Giovanna Cutrona & Massimo Gentile. (2020) An in-depth evaluation of acalabrutinib for the treatment of mantle-cell lymphoma. Expert Opinion on Pharmacotherapy 21:1, pages 29-38.
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