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Review

Is there a role for thioguanine therapy in IBD in 2017 and beyond?

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Pages 473-486 | Received 06 Dec 2016, Accepted 08 Feb 2017, Published online: 20 Feb 2017

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Ahmed B. Bayoumy, Melek Simsek, Margien L. Seinen, Chris J.J. Mulder, Azhar Ansari, Godefridus J. Peters & Nanne K. De Boer. (2020) The continuous rediscovery and the benefit–risk ratio of thioguanine, a comprehensive review. Expert Opinion on Drug Metabolism & Toxicology 16:2, pages 111-123.
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Articles from other publishers (15)

Nicola Pugliese, Lucia Giuli, Elisabetta Mastrorocco, Francesco Santopaolo, Giacomo Marcozzi, Cristina Bezzio, Arianna Dal Buono, Roberto Gabbiadini, Antonio Gasbarrini, Francesca Romana Ponziani, Alessandro Armuzzi & Alessio Aghemo. (2023) Exploring the link: Porto-sinusoidal vascular disorder and inflammatory bowel disease – A comprehensive narrative review. Digestive and Liver Disease.
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Nanne K H de Boer, Melek Simsek, Berrie Meijer, Markus F Neurath, Ad van Bodegraven & Chris J J Mulder. (2023) Drug rediscovery in gastroenterology: from off-label to on-label use of thioguanine in inflammatory bowel disease. Gut 72:10, pages 1985-1991.
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Anuraag Jena, Pardhu B Neelam, Harshavardhan Telaprolu, Uday Kiran Mangipudi, Usha Dutta, Shaji Sebastian & Vishal Sharma. (2023) Effectiveness and safety of thioguanine as a maintenance therapy of inflammatory bowel disease: Systematic review, meta-analysis and meta-regression. Clinics and Research in Hepatology and Gastroenterology 47:7, pages 102155.
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Ali Eqbal, Alicia Martin, James D. Doecke & Desmond Patrick. (2022) Low‐dose thioguanine guided by therapeutic drug monitoring is a safe and effective alternative in inflammatory bowel disease patients intolerant to conventional thiopurines. Internal Medicine Journal 53:4, pages 559-567.
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Rezvan Rahimi, Mohammad Solimannejad & Mostafa Soleimannejad. (2022) Two-dimensionalcovalent triazine frameworks as superior nanocarriers for the delivery of thioguanine anti-cancer drugs: a periodic DFT study. New Journal of Chemistry 46:32, pages 15635-15644.
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Paulina Núñez F, Rodrigo Quera, Constanza Bay, Fabiola Castro & Gabriel Mezzano. (2022) Drug-Induced Liver Injury Used in the Treatment of Inflammatory Bowel Disease. Journal of Crohn's and Colitis 16:7, pages 1168-1176.
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Anke L. H. Nguyen & Miles P. Sparrow. (2020) Evolving Role of Thiopurines in Inflammatory Bowel Disease in the Era of Biologics and New Small Molecules. Digestive Diseases and Sciences 66:10, pages 3250-3262.
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Kun Harismah, Narjes Hajali & Hasan Zandi. (2021) 6-Thioguanine bimolecular formation for dual chelation of iron: DFT study. Computational and Theoretical Chemistry 1202, pages 113308.
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Carla J. Gargallo-Puyuelo, Viviana Laredo & Fernando Gomollón. (2021) Thiopurines in Inflammatory Bowel Disease. How to Optimize Thiopurines in the Biologic Era?. Frontiers in Medicine 8.
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Kelly Cushing & Peter D. R. Higgins. (2021) Management of Crohn Disease—Reply. JAMA 325:17, pages 1794.
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Sjoerd de Hoogd, Dennis R. Wong, Durk R. de Vries & Ankie M. Harmsze. (2019) Severe pancytopenia and aspergillosis caused by thioguanine in a thiopurine S-methyltransferase deficient patient: a case report. European Journal of Gastroenterology & Hepatology 31:12, pages 1592-1596.
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Melek Simsek, Debbie S. Deben, Carmen S. Horjus, Melanie V. Bénard, Birgit I. Lissenberg-Witte, Hans J. C. Buiter, Matthijs van Luin, Margien L. Seinen, Chris J. J. Mulder, Dennis R. Wong, Nanne K. H. de Boer & Adriaan A. van Bodegraven. (2019) Sustained effectiveness, safety and therapeutic drug monitoring of tioguanine in a cohort of 274 IBD patients intolerant for conventional therapies. Alimentary Pharmacology & Therapeutics 50:1, pages 54-65.
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Melek Simsek, Berrie Meijer, Dewkoemar Ramsoekh, Gerd Bouma, Egbert-Jan van der Wouden, Bert den Hartog, Annemarie C. de Vries, Frank Hoentjen, Gerard Dijkstra, Sybrand Y. de Boer, Jeroen M. Jansen, Andrea E. van der Meulen, Ruud Beukers, Menno A. Brink, Toos Steinhauser, Bas Oldenburg, Lennard P. Gilissen, Ton H. Naber, Marc A. Verhagen, Nanne K.H. de Boer & Chris J.J. Mulder. (2019) Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients. Clinical Gastroenterology and Hepatology 17:3, pages 568-570.
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Floris F. van den Brand, Carin M. J. van Nieuwkerk, Bart J. Verwer, Ynto S. de Boer, Nanne K. H. de Boer, Chris J. J. Mulder, Elisabeth Bloemena, Christine M. Bakker, Jan M. Vrolijk, Joost P. H. Drenth, Adriaan C. I. T. L. Tan, Frank ter Borg, Martijn J. ter Borg, Sven J. van den Hazel, Akin Inderson, Maarten E. Tushuizen & Gerd Bouma. (2018) Biochemical efficacy of tioguanine in autoimmune hepatitis: a retrospective review of practice in the Netherlands. Alimentary Pharmacology & Therapeutics 48:7, pages 761-767.
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Ramya Movva, Alison Haywood, Sohil A Khan, Timothy HJ Florin & Iulia Oancea. (2017) Critical assessment of thioguanine treatment for inflammatory bowel diseases: Is it time to rehabilitate this treatment?. Journal of Digestive Diseases 18:9, pages 529-536.
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