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Expert Review of Gastroenterology & Hepatology Volume 14, 2020 - Issue 9: Developments in the pharmacological and endoscopic treatment of inflammatory bowel disease
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Review

JAK selectivity: more precision less troubles

Giulia Rodaa IBD Unit, Humanitas Clinical and Research Center – IRCCS -, Milan, ItalyView further author information
,
Arianna Dal Buonoa IBD Unit, Humanitas Clinical and Research Center – IRCCS -, Milan, ItalyView further author information
,
Marjorie Argollob Gastroenterology, Universidade Federal De São Paulo, São Paulo, BrazilORCID Iconhttps://orcid.org/0000-0001-9867-8861View further author information
ORCID Icon &
Silvio Danesea IBD Unit, Humanitas Clinical and Research Center – IRCCS -, Milan, Italy;c Department of Biomedical Sciences, Humanitas University, Milan, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7341-1351View further author information
ORCID Icon
Pages 789-796 | Received 07 Apr 2020, Accepted 05 Jun 2020, Published online: 16 Jun 2020

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Alessandro Mannucci, Ferdinando D’Amico, Ahmad El Saadi, Laurent Peyrin-Biroulet & Silvio Danese. (2022) Filgotinib for moderately to severely active ulcerative colitis. Expert Review of Gastroenterology & Hepatology 16:10, pages 927-940.
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Silvana LeitBhaskar SrivastavaNathan E. GenungJoshua J. McElweeDenise LevasseurScott D. Edmondson. 2023. 2023 Medicinal Chemistry Reviews. 2023 Medicinal Chemistry Reviews 157 185 .
Bridgette Andrew, Ashish Srinivasan, Annie Zhou & Abhinav Vasudevan. (2023) Letter: Elderly onset inflammatory bowel disease—Treat to target approach is still warranted. Alimentary Pharmacology & Therapeutics 58:5, pages 556-557.
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Silvana Leit, Jeremy Greenwood, Samantha Carriero, Sayan Mondal, Robert Abel, Mark Ashwell, Heather Blanchette, Nicholas A. Boyles, Mark Cartwright, Alan Collis, Shulu Feng, Phani Ghanakota, Geraldine C. Harriman, Vinayak Hosagrahara, Neelu Kaila, Rosanna Kapeller, Salma B. Rafi, Donna L. Romero, Paul M. Tarantino, Jignesh Timaniya, Angela V. Toms, Ronald T. Wester, William Westlin, Bhaskar Srivastava, Wenyan Miao, Peter Tummino, Joshua J. McElwee, Scott D. Edmondson & Craig E. Masse. (2023) Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279. Journal of Medicinal Chemistry 66:15, pages 10473-10496.
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Vincent Joustra, Andrew Y F Li Yim, Sara van Gennep, Ishtu Hageman, Tristan de Waard, Evgeni Levin, Peter Lauffer, Wouter de Jonge, Peter Henneman, Mark Löwenberg & Geert D’Haens. (2023) Peripheral Blood DNA Methylation Signatures and Response to Tofacitinib in Moderate-to-severe Ulcerative Colitis. Journal of Crohn's and Colitis.
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Pablo A. Olivera, Juan S. Lasa, Giovanni Peretto, Stephane Zuily, Silvio Danese & Laurent Peyrin‐Biroulet. (2023) Review article: Risk of cardiovascular events in patients with inflammatory bowel disease receiving small molecule drugs. Alimentary Pharmacology & Therapeutics 57:11, pages 1231-1248.
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Jia-Jia Lang, You Lv, Bostjan Kobe, Hongfei Chen, Yan Tan, Limei Chen, Xuechuan Wang, Pengbing Mi, Xing Zheng & Ying-Wu Lin. (2023) Discovery of C-5 Pyrazole-Substituted Pyrrolopyridine Derivatives as Potent and Selective Inhibitors for Janus Kinase 1. Journal of Medicinal Chemistry 66:10, pages 6725-6742.
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Silvana Leit, Jeremy R. Greenwood, Sayan Mondal, Samantha Carriero, Markus Dahlgren, Geraldine C. Harriman, Joshua J. Kennedy-Smith, Rosana Kapeller, Jon P. Lawson, Donna L. Romero, Angela V. Toms, Mee Shelley, Ronald T. Wester, William Westlin, Joshua J. McElwee, Wenyan Miao, Scott D. Edmondson & Craig E. Masse. (2022) Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorganic & Medicinal Chemistry Letters 73, pages 128891.
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Jin Huang, Chi Zhou, Jinniu Deng & Jianfeng Zhou. (2022) JAK inhibition as a new treatment strategy for patients with COVID-19. Biochemical Pharmacology 202, pages 115162.
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Yihao Li, Dan Meng, Jiali Xie, Ruoyu Li, Zifan Wang, Jinlong Li, Lin Mou, Xinhao Deng & Ping Deng. (2022) Design of Rational JAK3 Inhibitors Based on the Parent Core Structure of 1,7-Dihydro-Dipyrrolo [2,3-b:3′,2′-e] Pyridine. International Journal of Molecular Sciences 23:10, pages 5437.
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Patrycja Dudek, Adam Fabisiak, Hubert Zatorski, Ewa Malecka-Wojciesko & Renata Talar-Wojnarowska. (2021) Efficacy, Safety and Future Perspectives of JAK Inhibitors in the IBD Treatment. Journal of Clinical Medicine 10:23, pages 5660.
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