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Expert Review of Gastroenterology & Hepatology Volume 15, 2021 - Issue 7
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Review

Defining the current role of immune checkpoint inhibitors in the treatment of mismatch repair-deficient/microsatellite stability-high colorectal cancer and shedding light on future approaches

Elaine TanDepartment of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USAView further author information
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Ibrahim Halil SahinDepartment of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USACorrespondence[email protected]
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Pages 735-742 | Received 12 Nov 2020, Accepted 02 Feb 2021, Published online: 18 Feb 2021

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Inken Salewski, Julia Henne, Leonie Engster, Paula Krone, Bjoern Schneider, Caterina Redwanz, Heiko Lemcke, Larissa Henze, Christian Junghanss & Claudia Maletzki. (2022) CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors. OncoImmunology 11:1.
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Articles from other publishers (12)

Jiajing Zhao, Jiazheng Quan, Weilin Chen & Xiaojun Xie. (2023) Grid2 interacting protein is a potential biomarker related to immune infiltration in colorectal cancer. European Journal of Medical Research 28:1.
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Chuanxiu Zeng, Mengchao Wang, Shuqi Xie, Na Wang, Zhen Wang, Dan Yi, Fanming Kong & Liwei Chen. (2023) Clinical research progress on BRAF V600E-mutant advanced colorectal cancer. Journal of Cancer Research and Clinical Oncology 149:17, pages 16111-16121.
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Muhammet Ozer, Charan Thej Reddy Vegivinti, Masood Syed, Morgan E. Ferrell, Cyndi Gonzalez Gomez, Svea Cheng, Jennifer Holder-Murray, Tullia Bruno, Anwaar Saeed & Ibrahim Halil Sahin. (2023) Neoadjuvant Immunotherapy for Patients with dMMR/MSI-High Gastrointestinal Cancers: A Changing Paradigm. Cancers 15:15, pages 3833.
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Ibrahim Halil Sahin, Janie Zhang, Turcin Saridogan, Vikram Gorantla, John Rhree, Monica Malhotra, Roby Thomas, Dennis Hsu & Anwaar Saeed. (2023) Neoadjuvant Immune Checkpoint Inhibitor Therapy for Patients With Microsatellite Instability-High Colorectal Cancer: Shedding Light on the Future. JCO Oncology Practice 19:5, pages 251-259.
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Anwaar Saeed, Robin Park, Junqiang Dai, Raed Al-Rajabi, Anup Kasi, Joaquina Baranda, Stephen Williamson, Azhar Saeed, Jacob Ripp, Zachary Collins, Kelly Mulvaney, Molly Shugrue, Jeanette Firth-Braun, Andrew K. Godwin, Rashna Madan, Milind Phadnis & Weijing Sun. (2023) Cabozantinib plus durvalumab in advanced gastroesophageal cancer and other gastrointestinal malignancies: Phase Ib CAMILLA trial results. Cell Reports Medicine 4:2, pages 100916.
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Iman M. Talaat, Noha M. Elemam, Shroque Zaher & Maha Saber-Ayad. (2022) Checkpoint molecules on infiltrating immune cells in colorectal tumor microenvironment. Frontiers in Medicine 9.
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Canan Karan, Elaine Tan, Humaira Sarfraz, Todd C. Knepper, Christine M. Walko, Seth Felder, Richard Kim & Ibrahim Halil Sahin. (2022) Human Epidermal Growth Factor Receptor 2–Targeting Approaches for Colorectal Cancer: Clinical Implications of Novel Treatments and Future Therapeutic Avenues. JCO Oncology Practice 18:8, pages 545-554.
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Xuan Zhang, Renfang Yang, Tao Wu, Xinyi Cai, Guoyu Li, Kun Yu, Yong Li, Rong Ding, Chao Dong, Jinsha Li, Ruixi Hu, Qing Feng & Yunfeng Li. (2022) Efficacy and Safety of Neoadjuvant Monoimmunotherapy With PD-1 Inhibitor for dMMR/MSI⁃H Locally Advanced Colorectal Cancer: A Single-Center Real-World Study. Frontiers in Immunology 13.
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Ibrahim Halil Sahin, Kristen K. Ciombor, Luis A. Diaz, James Yu & Richard Kim. (2022) Immunotherapy for Microsatellite Stable Colorectal Cancers: Challenges and Novel Therapeutic Avenues. American Society of Clinical Oncology Educational Book:42, pages 242-253.
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Xuan Zhang, Tao Wu, Xinyi Cai, Jianhua Dong, Cuifeng Xia, Yongchun Zhou, Rong Ding, Renfang Yang, Jing Tan, Lijuan Zhang, Ya Zhang, Yuqin Wang, Chao Dong & Yunfeng Li. (2022) Neoadjuvant Immunotherapy for MSI-H/dMMR Locally Advanced Colorectal Cancer: New Strategies and Unveiled Opportunities. Frontiers in Immunology 13.
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Inken Salewski, Julia Henne, Leonie Engster, Bjoern Schneider, Heiko Lemcke, Anna Skorska, Peggy Berlin, Larissa Henze, Christian Junghanss & Claudia Maletzki. (2021) Combined Gemcitabine and Immune-Checkpoint Inhibition Conquers Anti-PD-L1 Resistance in Low-Immunogenic Mismatch Repair-Deficient Tumors. International Journal of Molecular Sciences 22:11, pages 5990.
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Jeeyun A. Kim, Rachel Ceccarelli & Christine Y. Lu. (2021) Pharmacogenomic Biomarkers in US FDA-Approved Drug Labels (2000–2020). Journal of Personalized Medicine 11:3, pages 179.
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