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Expert Review of Respiratory Medicine Volume 10, 2016 - Issue 9
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Review

Exercise intolerance in pulmonary hypertension: mechanism, evaluation and clinical implications

Abraham Samuel BabuDepartment of Physiotherapy, School of Allied Health Sciences, Manipal University, Manipal, Karnataka, IndiaCorrespondence[email protected]
,
Ross ArenaDepartment of Physical Therapy and Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, USA
,
Jonathan MyersVeterans Affairs Health Center, Stanford University, Palo Alto, CA, USA
,
Ramachandran PadmakumarDepartment of Cardiology, Kasturba Medical College, Manipal University, Manipal, India
,
Arun G. MaiyaDepartment of Physiotherapy, School of Allied Health Sciences, Manipal University, Manipal, Karnataka, India
,
Lawrence P. CahalinDepartment of Physical Therapy, Millers School of Medicine, Miami, FL, USA
,
Aaron B. WaxmanPulmonary Vascular Disease Program, Dyspnea and Performance Evaluation Center, Pulmonary Critical Care Medicine, Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
&
Carl J. LavieDepartment of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA, USA
 show all
Pages 979-990 | Received 05 Feb 2016, Accepted 16 May 2016, Published online: 10 Jun 2016

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W. Cameron McGuire, Mona Alotaibi, Timothy A. Morris, Nick H. Kim & Timothy M. Fernandes. (2021) Chronic Thromboembolic Disease: Epidemiology, Assessment with Invasive Cardiopulmonary Exercise Testing, and Options for Management. Structural Heart 5:2, pages 120-127.
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Ahmad Sabbahi, Richard Severin, Cemal Ozemek, Shane A. Phillips & Ross Arena. (2020) The role of cardiopulmonary exercise testing and training in patients with pulmonary hypertension: making the case for this assessment and intervention to be considered a standard of care. Expert Review of Respiratory Medicine 14:3, pages 317-327.
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Abraham Samuel Babu, Norman R. Morris, Ross Arena & Jonathan Myers. (2018) Exercise-based evaluations and interventions for pulmonary hypertension with connective tissue disorders. Expert Review of Respiratory Medicine 12:7, pages 615-622.
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Articles from other publishers (22)

Buse Ozcan Kahraman, Aylin Tanriverdi, Sema Savci, Hüseyin Odaman, Bahri Akdeniz, Can Sevinc, Ismail Ozsoy, Serap Acar, Ali Balci, Agah Baran & Ebru Ozpelit. (2023) Effects of Inspiratory Muscle Training in Patients With Pulmonary Hypertension. The American Journal of Cardiology 203, pages 406-413.
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Akhila Satyamurthy, Ganesha Poojary, Grace Dibben, Ramachandran Padmakumar, Rod S. Taylor & Abraham Samuel Babu. (2023) Exercise Training in Pulmonary Hypertension. Journal of Cardiopulmonary Rehabilitation and Prevention 43:4, pages 237-244.
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Norman R Morris, Fiona D Kermeen, Arwel W Jones, Joanna YT Lee & Anne E Holland. (2023) Exercise-based rehabilitation programmes for pulmonary hypertension. Cochrane Database of Systematic Reviews 2023:3.
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Mariusz Wojciuk, Zofia Dzięcioł-Anikiej, Katarzyna Kaniewska, Mariusz Ciołkiewicz, Diana Moskal-Jasińska & Anna Kuryliszyn-Moskal. (2022) Exercise Training as a Non-Pharmacological Therapy for Patients with Pulmonary Arterial Hypertension: Home-Based Rehabilitation Program and Training Recommendations. Journal of Clinical Medicine 11:23, pages 6932.
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J. Alberto Neder, Devin B. Phillips, Denis E. O'Donnell & Jerome A. Dempsey. (2022) Excess ventilation and exertional dyspnoea in heart failure and pulmonary hypertension. European Respiratory Journal 60:5, pages 2200144.
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Masatsugu Okamura, Masaaki Konishi, Yusuke Saigusa, Shuji Ando, Mina Nakayama, Naohiro Komura, Teruyasu Sugano, Kouichi Tamura & Takeshi Nakamura. (2022) Impact of grip strength and gait speed on exercise tolerance in patients with pulmonary hypertension without left heart disease. Heart and Vessels 37:11, pages 1928-1936.
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Gary Marshall Long, Ashley D. Troutman, Derrick A. Gray, Amanda J. Fisher, Tim Lahm, Andrew R. Coggan & Mary Beth Brown. (2022) Skeletal muscle blood flow during exercise is reduced in a rat model of pulmonary hypertension. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 323:4, pages R561-R570.
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Ozge Ertan, Goksen Kuran Aslan, Buket Akinci, Ahmet Kaya Bilge, Murat Inanc & Gulfer Okumus. (2022) Effect of Ground-Based Walk Training in Pulmonary Hypertension. The American Journal of Cardiology 174, pages 172-178.
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Melih Zeren, Rengin Demir, Umit Yasar Sinan, Rustem Mustafaoglu, Abdurrahim Yildiz & Mehmet Serdar Kucukoglu. (2022) Prevalence of musculoskeletal pain and its impact on quality of life and functional exercise capacity in patients with pulmonary arterial hypertension. Respiratory Medicine 193, pages 106759.
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Shraddha Shah, Ganesha Poojary & Abraham Samuel Babu. (2022) Exercise-Based Cardiopulmonary Rehabilitation: A Suitable Addition to Pharmacological Therapy for Pulmonary Hypertension. Mayo Clinic Proceedings 97:1, pages 190-191.
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Abraham S. Babu & Norman R. Morris. (2020) Patients support exercise training and rehabilitation—what more should we be doing to ensure cardiopulmonary rehabilitation is more readily available for those with pulmonary hypertension?. Pulmonary Circulation 10:4, pages 1-3.
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Cristine Schmidt, José A. Bovolini, Nádia Gonçalves, Francisco Vasques-Nóvoa, Maria do Amparo Andrade, Mário SantosAdelino Leite-Moreira, Tiago Henriques-Coelho, José Alberto Duarte & Daniel Moreira-Gonçalves. (2020) Exercise preconditioning prevents left ventricular dysfunction and remodeling in monocrotaline-induced pulmonary hypertension. Porto Biomedical Journal 5:5, pages e081.
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Goksen Kuran Aslan, Buket Akıncı, Ipek Yeldan & Gulfer Okumus. (2020) A randomized controlled trial on inspiratory muscle training in pulmonary hypertension: Effects on respiratory functions, functional exercise capacity, physical activity, and quality of life. Heart & Lung 49:4, pages 381-387.
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Buse Ozcan Kahraman, Sema Savci, Ismail Ozsoy, Agah Baran, Serap Acar, Ebru Ozpelit, Ali Balci, Can Sevinc & Bahri Akdeniz. (2020) Effects of neuromuscular electrical stimulation in patients with pulmonary arterial hypertension: a randomized controlled pilot study. Journal of Cardiology 75:6, pages 702-708.
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Abraham S Babu, Anne E Holland & Norman R Morris. (2019) Exercise-Based Rehabilitation to Improve Exercise Capacity and Quality of Life in Pulmonary Arterial Hypertension. Physical Therapy 99:9, pages 1126-1131.
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Abraham Samuel Babu, Ramachandran Padmakumar, Krishnanand Nayak, Ranjan Shetty, Aswini Kumar Mohapatra & Arun G. Maiya. (2019) Effects of home-based exercise training on functional outcomes and quality of life in patients with pulmonary hypertension: A randomized clinical trial. Indian Heart Journal 71:2, pages 161-165.
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Bigyan Pudasaini, Guo-ling Yang, Chen Yang, Jian Guo, Ping Yuan, Yang Wen-lan, Rui Zhang, Lan Wang, Qin-Hua Zhao, Su-Gang Gong, Rong Jiang, Tian-Xiang Chen, Xiong Wei & Jin-Ming Liu. (2018) Characteristics of exercise capacity in female systemic lupus erythematosus associated pulmonary arterial hypertension patients. BMC Cardiovascular Disorders 18:1.
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William M. OldhamRudolf K.F. OliveiraRui-Sheng WangAlexander R. OpotowskyDavid M. RubinsJon HainerBradley M. WertheimGeorge A. AlbaGaurav ChoudharyAdrienn TornyosCalum A. MacRaeJoseph LoscalzoJane A. LeopoldAaron B. WaxmanHorst OlschewskiGabor KovacsDavid M. SystromBradley A. Maron. (2018) Network Analysis to Risk Stratify Patients With Exercise Intolerance. Circulation Research 122:6, pages 864-876.
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Ping Yuan, Tian-Xiang Chen, Bigyan Pudasaini, Jie Zhang, Jian Guo, Si-Jin Zhang, Lan Wang, Qin-Hua Zhao, Su-Gang Gong, Rong Jiang, Wen-Hui Wu, Jing He, Jin-Ming Liu & Qing-Hua Hu. (2017) Sex-specific cardiopulmonary exercise testing indices related to hemodynamics in idiopathic pulmonary arterial hypertension. Therapeutic Advances in Respiratory Disease 11:3, pages 135-145.
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Mary Beth BrownEvandro NevesGary LongJeremy GraberBrett GladishAndrew WisemanMatthew OwensAmanda J. FisherRobert G. PressonIrina Petrache, Jeffrey KlineTim Lahm. (2017) High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 312:2, pages R197-R210.
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Norman R Morris, Fiona D Kermeen & Anne E Holland. (2017) Exercise-based rehabilitation programmes for pulmonary hypertension. Cochrane Database of Systematic Reviews 2017:2.
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Manuel J. Richter, Jan Grimminger, Britta Krüger, Hossein A. Ghofrani, Frank C. Mooren, Henning Gall, Christian Pilat & Karsten Krüger. (2017) Effects of exercise training on pulmonary hemodynamics, functional capacity and inflammation in pulmonary hypertension. Pulmonary Circulation 7:1, pages 20-37.
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