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Review Article

Young‐onset sporadic amyotrophic lateral sclerosis: A distinct nosological entity?

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Pages 323-327 | Received 28 Mar 2007, Accepted 02 Jul 2007, Published online: 10 Jul 2009

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Tessa Kliest, Ruben P.A. Van Eijk, Ammar Al-Chalabi, Alberto Albanese, Peter M. Andersen, Maria Del Mar Amador, Geir BrÅthen, Veronique Brunaud-Danel, Lev Brylev, William Camu, Mamede De Carvalho, Cristina Cereda, Hakan Cetin, Delia Chaverri, Adriano Chiò, Philippe Corcia, Philippe Couratier, Fabiola De Marchi, Claude Desnuelle, Michael A. Van Es, JesÚs Esteban, Massimiliano Filosto, Alberto GarcÍa Redondo, Julian Grosskreutz, Clemens O. Hanemann, Trygve HolmØy, Helle HØyer, Caroline Ingre, Blaz Koritnik, Magdalena Kuzma-Kozakiewicz, Thomas Lambert, Peter N. Leigh, Christian Lunetta, Jessica Mandrioli, Christopher J. Mcdermott, Thomas Meyer, Jesus S. Mora, Susanne Petri, MÓnica Povedano, Evy Reviers, Nilo Riva, Kit C.B. Roes, Miguel Á. Rubio, FranÇois Salachas, Stayko Sarafov, Gianni SorarÙ, Zorica Stevic, Kirsten Svenstrup, Anette Torvin MØller, Martin R. Turner, Philip Van Damme, Lucie A.G. Van Leeuwen, Luis Varona, Juan F. VÁzquez Costa, Markus Weber, Orla Hardiman & Leonard H. Van Den Berg. (2022) Clinical trials in pediatric ALS: a TRICALS feasibility study. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 23:7-8, pages 481-488.
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Miguel Oliveira Santos, Marta Gromicho, Susana Pinto & Mamede De carvalho. (2020) Clinical characteristics in young-adult ALS – results from a Portuguese cohort study. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 21:7-8, pages 620-623.
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Benoit Marin, Imen Kacem, Mouhamadou Diagana, Marion Boulesteix, Riadh Gouider, Pierre Marie Preux & Philippe Couratier. (2012) Juvenile and adult-onset ALS/MND among Africans: incidence, phenotype, survival: A review. Amyotrophic Lateral Sclerosis 13:3, pages 276-283.
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Mary Kay Floeter & Reversa Mills. (2009) Progression in primary lateral sclerosis: A prospective analysis. Amyotrophic Lateral Sclerosis 10:5-6, pages 339-346.
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Miguel Oliveira Santos, Marta Gromicho, Susana Pinto, Ana Catarina Pronto-Laborinho & Mamede de Carvalho. (2023) Clinical characteristics in amyotrophic lateral sclerosis with Sub-Saharan Africa ancestry – A Portuguese hospital-based cohort study. Clinical Neurology and Neurosurgery 227, pages 107674.
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Peter S. Spencer, Valerie S. Palmer, Glen E. Kisby, Emmeline Lagrange, B. Zane Horowitz, Raquel Valdes Angues, Jacques Reis, Jean-Paul Vernoux, Cédric Raoul & William Camu. (2023) Early-onset, conjugal, twin-discordant, and clusters of sporadic ALS: Pathway to discovery of etiology via lifetime exposome research. Frontiers in Neuroscience 17.
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Peter S. Spencer. (2022) Parkinsonism and motor neuron disorders: Lessons from Western Pacific ALS/PDC. Journal of the Neurological Sciences 433, pages 120021.
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Sanggon Lee, Jinseok Park, Ki-Wook Oh & Seung Hyun Kim. (2020) Clinical Characteristics of Korean Juvenile Amyotrophic Lateral Sclerosis. Korean Journal of Neuromuscular Disorders 12:2, pages 17-23.
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Julia Costa, Linda Streich, Susana Pinto, Ana Pronto-Laborinho, Manfred Nimtz, Harald S. Conradt & Mamede de Carvalho. (2019) Exploring Cerebrospinal Fluid IgG N-Glycosylation as Potential Biomarker for Amyotrophic Lateral Sclerosis. Molecular Neurobiology 56:8, pages 5729-5739.
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W.B.V.R. Pinto, R. Debona, P.P. Nunes, A.C.D. Assis, C.G. Lopes, T. Bortholin, R.B. Dias, F.G.M. Naylor, M.A.T. Chieia, P.V.S. Souza & A.S.B. Oliveira. (2019) Atypical Motor Neuron Disease variants: Still a diagnostic challenge in Neurology. Revue Neurologique 175:4, pages 221-232.
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C. Tard, L. Defebvre, C. Moreau, D. Devos & V. Danel-Brunaud. (2017) Clinical features of amyotrophic lateral sclerosis and their prognostic value. Revue Neurologique 173:5, pages 263-272.
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Hooi Ling Teoh, Kate Carey, Hugo Sampaio, David Mowat, Tony Roscioli & Michelle Farrar. (2017) Inherited Paediatric Motor Neuron Disorders: Beyond Spinal Muscular Atrophy. Neural Plasticity 2017, pages 1-22.
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Hong-Fu Li & Zhi-Ying Wu. (2016) Genotype-phenotype correlations of amyotrophic lateral sclerosis. Translational Neurodegeneration 5:1.
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Artemios K. Artemiadis, Christos Peppas, Sotiris Giannopoulos, Vasiliki Zouvelou & Nikos Triantafyllou. (2016) Case of Young-Onset Sporadic Amyotrophic Lateral Sclerosis. Journal of Clinical Neuromuscular Disease 17:4, pages 220-222.
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Júlia Costa & Mamede de Carvalho. (2016) Emerging molecular biomarker targets for amyotrophic lateral sclerosis. Clinica Chimica Acta 455, pages 7-14.
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P.A. McCombe, C. Pfluger, P. Singh, C.Y.H. Lim, C. Airey & R.D. Henderson. (2015) Serial measurements of phosphorylated neurofilament-heavy in the serum of subjects with amyotrophic lateral sclerosis. Journal of the Neurological Sciences 353:1-2, pages 122-129.
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Ilaria Bicchi, Carla Emiliani, Angelo Vescovi & Sabata Martino. (2015) The Big Bluff of Amyotrophic Lateral Sclerosis Diagnosis: The Role of Neurodegenerative Disease Mimics. Neurodegenerative Diseases 15:6, pages 313-321.
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M Sabatelli, A Conte & M Zollino. (2013) Clinical and genetic heterogeneity of amyotrophic lateral sclerosis. Clinical Genetics 83:5, pages 408-416.
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Zhang-Yu Zou, Li-Ying Cui, Qing Sun, Xiao-Guang Li, Ming-Sheng Liu, Yan Xu, Yan Zhou & Xun-Zhe Yang. (2013) De novo FUS gene mutations are associated with juvenile-onset sporadic amyotrophic lateral sclerosis in China. Neurobiology of Aging 34:4, pages 1312.e1-1312.e8.
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F. Baumann, R.D. Henderson, P.G. Ridall, A.N. Pettitt & Pamela A. McCombe. (2012) Use of Bayesian MUNE to show differing rate of loss of motor units in subgroups of ALS. Clinical Neurophysiology 123:12, pages 2446-2453.
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M. R. Turner, J. Barnwell, A. Al-Chalabi & A. Eisen. (2012) Young-onset amyotrophic lateral sclerosis: historical and other observations. Brain 135:9, pages 2883-2891.
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Nicholas A. LansonJr.Jr. & Udai Bhan Pandey. (2012) FUS-related proteinopathies: Lessons from animal models. Brain Research 1462, pages 44-60.
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Benoit Marin, Imen Kacem, Mouhamadou Diagana, Marion Boulesteix, Riadh Gouider, Pierre Marie Preux & Philippe Couratier. (2012) Juvenile and adult-onset ALS/MND among Africans: incidence, phenotype, survival: A review. Amyotrophic Lateral Sclerosis, pages 1-8.
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Amelia Conte, Serena Lattante, Marcella Zollino, Giuseppe Marangi, Marco Luigetti, Alessandra Del Grande, Serenella Servidei, Federica Trombetta & Mario Sabatelli. (2012) P525L FUS mutation is consistently associated with a severe form of juvenile Amyotrophic Lateral Sclerosis. Neuromuscular Disorders 22:1, pages 73-75.
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Faisal Fecto & Teepu Siddique. (2011) SIGMAR1 mutations, genetic heterogeneity at the chromosome 9p locus, and the expanding etiological diversity of amyotrophic lateral sclerosis . Annals of Neurology 70:6, pages 867-870.
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Faisal Fecto & Teepu Siddique. (2011) Making Connections: Pathology and Genetics Link Amyotrophic Lateral Sclerosis with Frontotemporal Lobe Dementia. Journal of Molecular Neuroscience 45:3, pages 663-675.
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F.J. Rodríguez de Rivera, C. Oreja Guevara, I. Sanz Gallego, B. San José Valiente, A. Santiago Recuerda, M.A. Gómez Mendieta, J. Arpa & E. Díez Tejedor. (2011) Outcome of patients with amyotrophic lateral sclerosis attending in a multidisciplinary care unit. Neurología (English Edition) 26:8, pages 455-460.
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F.J. Rodríguez de Rivera, C. Oreja Guevara, I. Sanz Gallego, B. San José Valiente, A. Santiago Recuerda, M.A. Gómez Mendieta, J. Arpa & E. Díez Tejedor. (2011) Evolución de pacientes con esclerosis lateral amiotrófica atendidos en una unidad multidisciplinar. Neurología 26:8, pages 455-460.
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Pamela A. McCombe & Robert D. Henderson. (2010) Effects of gender in amyotrophic lateral sclerosis. Gender Medicine 7:6, pages 557-570.
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D. BäumerD. HiltonS.M.L. PaineM.R. TurnerJ. LoweK. TalbotO. Ansorge. (2010) Juvenile ALS with basophilic inclusions is a FUS proteinopathy with FUS mutations . Neurology 75:7, pages 611-618.
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