Advanced search
Publication Cover
Amyotrophic Lateral Sclerosis Volume 9, 2008 - Issue 1
Journal homepage
237
Views
34
CrossRef citations to date
0
Altmetric
Original Article

R(+) pramipexole as a mitochondrially focused neuroprotectant: Initial early phase studies in ALS

Hua Wang Department of Neurology
,
Kylyana S. Larriviere Department of Neurology
,
Kristen E. Keller Department of Neurology
,
Kathleen A. Ware Department of Neurology, University of Nebraska Medical Center/Neurology Associates, and Bryant LGH Medical Center, Lincoln, Nebraska
,
Ted M. Burns Department of Neurology
,
Mark A. Conaway Division of Biostatistics/Department of Public Health Sciences
,
David Lacomis Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
,
Gary L. Pattee Department of Neurology, University of Nebraska Medical Center/Neurology Associates, and Bryant LGH Medical Center, Lincoln, Nebraska
,
Lawrence H. Phillips II Department of Neurology
,
Nina J. Solenski Department of Neurology
,
Sasa A. Zivkovic Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
&
James P. Bennett Jr Department of Neurology; Center for the Study of Neurodegenerative Diseases, University of Virginia School of Medicine, Charlottesville, VirginiaCorrespondence[email protected]
 show all
Pages 50-58 | Received 19 Apr 2007, Accepted 22 Oct 2007, Published online: 10 Jul 2009

Citations (34)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Abigail DeLoach, Michael Cozart, Arianna Kiaei & Mahmoud Kiaei. (2015) A retrospective review of the progress in amyotrophic lateral sclerosis drug discovery over the last decade and a look at the latest strategies. Expert Opinion on Drug Discovery 10:10, pages 1099-1118.
Read now
Philippe Corcia & Paul H Gordon. (2012) Amyotrophic lateral sclerosis and the clinical potential of dexpramipexole. Therapeutics and Clinical Risk Management 8, pages 359-366.
Read now
Ali Aamer Habib & Hiroshi Mitsumoto. (2011) Emerging drugs for amyotrophic lateral sclerosis. Expert Opinion on Emerging Drugs 16:3, pages 537-558.
Read now
Stefano Zoccolella, Andrea Santamato & Paolo Lamberti. (2009) Current and emerging treatments for amyotrophic lateral sclerosis. Neuropsychiatric Disease and Treatment 5, pages 577-595.
Read now

Articles from other publishers (30)

Nicholas J. Maragakis, Mamede de Carvalho & Michael D. Weiss. (2023) Therapeutic targeting of ALS pathways: Refocusing an incomplete picture . Annals of Clinical and Translational Neurology 10:11, pages 1948-1971.
Crossref
Pedro Soares, Catia Silva, Daniel Chavarria, Filomena S.G. Silva, Paulo J. Oliveira & Fernanda Borges. (2023) Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities. Ageing Research Reviews 83, pages 101790.
Crossref
Jia-Tong Li, Si-Qi Dong, Ting Qian, Wen-Bo Yang & Xiang-Jun Chen. (2022) Mouse Nerve Growth Factor Injection and Progression Rate in Patients With Amyotrophic Lateral Sclerosis: An Observational Study. Frontiers in Neurology 13.
Crossref
Maximillian Taro William Lee, William Mahy & Mark David Rackham. (2021) The medicinal chemistry of mitochondrial dysfunction: a critical overview of efforts to modulate mitochondrial health. RSC Medicinal Chemistry 12:8, pages 1281-1311.
Crossref
Lu Tang, Yun-peng Li, Juan Hu, Ai-hua Chen & Yingli Mo. (2021) Dexpramipexole attenuates myocardial ischemia/reperfusion injury through upregulation of mitophagy. European Journal of Pharmacology 899, pages 173962.
Crossref
Yutaka Nakagawa & Shizuo Yamada. (2021) A novel hypothesis on metal dyshomeostasis and mitochondrial dysfunction in amyotrophic lateral sclerosis: Potential pathogenetic mechanism and therapeutic implications. European Journal of Pharmacology 892, pages 173737.
Crossref
Samuele Ciceri, Patrizia Ferraboschi, Paride Grisenti, Shahrzad Reza Elahi, Carlo Castellano, Matteo Mori & Fiorella Meneghetti. (2020) (S)-Pramipexole and Its Enantiomer, Dexpramipexole: A New Chemoenzymatic Synthesis and Crystallographic Investigation of Key Enantiomeric Intermediates. Catalysts 10:8, pages 941.
Crossref
Satoru Morimoto, Shinichi Takahashi, Komei Fukushima, Hideyuki Saya, Norihiro Suzuki, Masashi Aoki, Hideyuki Okano & Jin Nakahara. (2019) Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis – Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial). Regenerative Therapy 11, pages 143-166.
Crossref
Klara Valko & Lukasz Ciesla. 2019. 63 117 .
Kewal K. JainKewal K. Jain. 2019. The Handbook of Neuroprotection. The Handbook of Neuroprotection 609 641 .
Koki Fujimori, Mitsuru Ishikawa, Asako Otomo, Naoki Atsuta, Ryoichi Nakamura, Tetsuya Akiyama, Shinji Hadano, Masashi Aoki, Hideyuki Saya, Gen Sobue & Hideyuki Okano. (2018) Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent. Nature Medicine 24:10, pages 1579-1589.
Crossref
James Bennett, Jeffrey Burns, Paul Welch & Rebecca Bothwell. (2016) Safety and Tolerability of R(+) Pramipexole in Mild-to-Moderate Alzheimer’s Disease. Journal of Alzheimer's Disease 49:4, pages 1179-1187.
Crossref
Jonathan S. Katz, Richard J. Barohn, Mazen M. Dimachkie & Hiroshi Mitsumoto. (2015) The Dilemma of the Clinical Trialist in Amyotrophic Lateral Sclerosis. Neurologic Clinics 33:4, pages 937-947.
Crossref
Valentin K. Gribkoff. 2015. The Functions, Disease‐Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria. The Functions, Disease‐Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria 295 321 .
Michael Jablonski, David S. Miller, Piera Pasinelli & Davide Trotti. (2015) ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis. Brain Research 1607, pages 1-14.
Crossref
Dong Wei, Chichih Wu, Ping He, Doug Kerr, Scott Stecher & Liyu Yang. (2014) Chiral liquid chromatography–tandem mass spectrometry assay to determine that dexpramipexole is not converted to pramipexole in vivo after administered in humans. Journal of Chromatography B 971, pages 133-140.
Crossref
Hans Lassmann, Jack van Horssen & Don Mahad. (2012) Progressive multiple sclerosis: pathology and pathogenesis. Nature Reviews Neurology 8:11, pages 647-656.
Crossref
A. Boscolo, J.A. Starr, V. Sanchez, N. Lunardi, M.R. DiGruccio, C. Ori, A. Erisir, P. Trimmer, J. Bennett & V. Jevtovic-Todorovic. (2012) The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: The importance of free oxygen radicals and mitochondrial integrity. Neurobiology of Disease 45:3, pages 1031-1041.
Crossref
Kambiz N. Alavian, Steven I. Dworetzky, Laura Bonanni, Ping Zhang, Silvio Sacchetti, Maria A. Mariggio, Marco Onofrj, Astrid Thomas, Hongmei Li, Jamie E. Mangold, Armando P. Signore, Ulrike DeMarco, Damon R. Demady, Panah Nabili, Emma Lazrove, Peter J.S. Smith, Valentin K. Gribkoff & Elizabeth A. Jonas. (2012) Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Research 1446, pages 1-11.
Crossref
Benjamin Chee Chuan Cheah, Steve Vucic & Matthew Colm Kiernan. (2012) Potential utility of biomarkers in the diagnosis and treatment of amyotrophic lateral sclerosis. Clinical Investigation 2:1, pages 107-117.
Crossref
Rachel F. Lane, Diana W. Shineman, John W. Steele, Linda (Bobbi) H. Lee & Howard M. Fillit. 2012. Current State of Alzheimer's Disease Research and Therapeutics. Current State of Alzheimer's Disease Research and Therapeutics 213 271 .
Claire Henchcliffe & M. Flint Beal. 2012. Mitochondrial Dysfunction in Neurodegenerative Disorders. Mitochondrial Dysfunction in Neurodegenerative Disorders 215 230 .
Merit Cudkowicz, Michael E Bozik, Evan W Ingersoll, Robert Miller, Hiroshi Mitsumoto, Jeremy Shefner, Dan H Moore, David Schoenfeld, James L Mather, Donald Archibald, Mary Sullivan, Craig Amburgey, Juliet Moritz & Valentin K Gribkoff. (2011) The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nature Medicine 17:12, pages 1652-1656.
Crossref
Michael E. Bozik, James L. Mather, William G. Kramer, Valentin K. Gribkoff & Evan W. Ingersoll. (2011) Safety, Tolerability, and Pharmacokinetics of KNS-760704 (Dexpramipexole) in Healthy Adult Subjects. The Journal of Clinical Pharmacology 51:8, pages 1177-1185.
Crossref
Lorne Zinman & Merit Cudkowicz. (2011) Emerging targets and treatments in amyotrophic lateral sclerosis. The Lancet Neurology 10:5, pages 481-490.
Crossref
Paul H. Gordon. (2011) Amyotrophic Lateral Sclerosis. CNS Drugs 25:1, pages 1-15.
Crossref
Kewal K. JainKewal K. Jain. 2011. The Handbook of Neuroprotection. The Handbook of Neuroprotection 385 408 .
Siân C. Barber & Pamela J. Shaw. (2010) Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target. Free Radical Biology and Medicine 48:5, pages 629-641.
Crossref
Tamara R. GoldenManisha Patel. (2009) Catalytic Antioxidants and Neurodegeneration. Antioxidants & Redox Signaling 11:3, pages 555-569.
Crossref
Valentin K. Gribkoff & Michael E. Bozik. (2008) KNS-760704 [(6R)-4,5,6,7-tetrahydro-N6-propyl-2, 6-benzothiazole-diamine dihydrochloride monohydrate] for the Treatment of Amyotrophic Lateral Sclerosis. CNS Neuroscience & Therapeutics 14:3, pages 215-226.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.