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Amyotrophic Lateral Sclerosis Volume 9, 2008 - Issue 5
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Original Article

A common haplotype within the PON1 promoter region is associated with sporadic ALS

John E. Landers Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, , Charlestown, MA, USACorrespondence[email protected]
,
Lijia Shi Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, , Charlestown, MA, USA
,
Ting-Jan Cho Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, , Charlestown, MA, USA
,
Jonathan D. Glass Center for Neurodegenerative Disease, School of Medicine, Emory University, , Atlanta, Georgia, USA
,
Christopher E. Shaw Department of Neurology, MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
P. Nigel Leigh Department of Neurology, MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
Frank Diekstra Department of Neurology, MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
Meraida Polak Center for Neurodegenerative Disease, School of Medicine, Emory University, , Atlanta, Georgia, USA
,
Ildefonso Rodriguez-Leyva Department of Neurology, Hospital Central, Colonia Universitaria, San Luis Potosi, Mexico
,
Stephan Niemann Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, , Charlestown, MA, USA
,
Bryan J. Traynor Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, , Charlestown, MA, USA
,
Diane Mckenna-Yasek Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, , Charlestown, MA, USA
,
Peter C. Sapp Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, , Charlestown, MA, USA
,
Ammar Al-Chalabi Department of Neurology, MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK
,
Anne-Marie A. Wills Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, , Charlestown, MA, USA
&
Robert H. Brown Jr Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, , Charlestown, MA, USA
 show all
Pages 306-314 | Received 02 Apr 2008, Published online: 10 Jul 2009

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Lada Rumora, Marija Grdić Rajković, Lara Milevoj Kopčinović, Dolores Pancirov, Ivana Čepelak & Tihana Žanić Grubišić. (2014) Paraoxonase 1 Activity in Patients with Chronic Obstructive Pulmonary Disease. COPD: Journal of Chronic Obstructive Pulmonary Disease 11:5, pages 539-545.
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Stefano Zoccolella, Caterina Bendotti, Ettore Beghi & Giancarlo Logroscino. (2010) Homocysteine levels and amyotrophic lateral sclerosis: A possible link. Amyotrophic Lateral Sclerosis 11:1-2, pages 140-147.
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Kun Chen, Xiaogang Wang, Dihang Li, Weiping Luo, Chuang Xue & Yong Kong. (2022) Association of Paraoxonase 1 Gene Polymorphisms with the Risk of Breast Fibroadenoma and Breast Cancer in the Females of Guangxi, China. Journal of Healthcare Engineering 2022, pages 1-5.
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Giuseppe Manco, Elena Porzio & Teresa Maria Carusone. (2021) Human Paraoxonase-2 (PON2): Protein Functions and Modulation. Antioxidants 10:2, pages 256.
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Rita Mejzini, Loren L. Flynn, Ianthe L. Pitout, Sue Fletcher, Steve D. Wilton & P. Anthony Akkari. (2019) ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?. Frontiers in Neuroscience 13.
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Federico Verde, Cinzia Tiloca, Claudia Morelli, Alberto Doretti, Barbara Poletti, Luca Maderna, Stefano Messina, Davide Gentilini, Isabella Fogh, Antonia Ratti, Vincenzo Silani & Nicola Ticozzi. (2019) PON1 is a disease modifier gene in amyotrophic lateral sclerosis: association of the Q192R polymorphism with bulbar onset and reduced survival. Neurological Sciences 40:7, pages 1469-1473.
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Marija Grdić Rajković, Sanja Popović-Grle, Andrea Vukić Dugac, Dunja Rogić, Ivana Rako, Margareta Radić Antolić, Mirela Beriša & Lada Rumora. (2018) PON1 gene polymorphisms in patients with chronic obstructive pulmonary disease . Journal of Clinical Pathology 71:11, pages 963-970.
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Efthimios Dardiotis, Vasileios Siokas, Maria Sokratous, Zisis Tsouris, Amalia Michalopoulou, Athina Andravizou, Metaxia Dastamani, Styliani Ralli, Marco Vinceti, Aristidis Tsatsakis & Georgios M. Hadjigeorgiou. (2018) Genetic polymorphisms in amyotrophic lateral sclerosis: Evidence for implication in detoxification pathways of environmental toxicants. Environment International 116, pages 122-135.
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Cristiane Pereira, Patricia Nardin, Daniela Fraga de Souza, Mateus Grings, Guilhian Leipnitz, Carlos Alberto Saraiva Gonçalves, Augusto Schneider, Renata Torres Abib, Sandra Costa Valle & Elizabete Helbig. (2016) Age at onset of caloric restriction and its effects on the redox profile of the rat hippocampus. Nutrire 41:1.
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Philipp G. Sand. (2016) The paraoxonase disruption hypothesis in sporadic ALS steamrolled. Neurological Sciences 37:6, pages 1017-1018.
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Xianjun Lao, Xiaogang Wang, Yanqiong Liu, Yu Lu, Dongmei Yang, Minyan Liu, Xiaolian Zhang, Chengzhi Rong, Xue Qin & Shan Li. (2015) Association of Paraoxonase 1 Gene Polymorphisms With the Risk of Hepatitis B Virus-related Liver Diseases in a Guangxi Population. Medicine 94:48, pages e2179.
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Pam Factor-Livak. 2015. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders 329 353 .
O.M. Peters & R.H. BrownJr.Jr.. 2015. Neurobiology of Brain Disorders. Neurobiology of Brain Disorders 262 280 .
Young Ho Lee, Jae-Hoon Kim, Young Ho Seo, Sung Jae Choi, Jong Dae Ji & Gwan Gyu Song. (2014) Paraoxonase 1 Q192R and L55M polymorphisms and susceptibility to amyotrophic lateral sclerosis: a meta-analysis. Neurological Sciences 36:1, pages 11-20.
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Federica Rizzo, Giulietta Riboldi, Sabrina Salani, Monica Nizzardo, Chiara Simone, Stefania Corti & Eva Hedlund. (2013) Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis. Cellular and Molecular Life Sciences 71:6, pages 999-1015.
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Emanuele D’Amico, Pam Factor-Litvak, Regina M. Santella & Hiroshi Mitsumoto. (2013) Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis. Free Radical Biology and Medicine 65, pages 509-527.
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Francesca Trojsi, Maria Monsurrò & Gioacchino Tedeschi. (2013) Exposure to Environmental Toxicants and Pathogenesis of Amyotrophic Lateral Sclerosis: State of the Art and Research Perspectives. International Journal of Molecular Sciences 14:8, pages 15286-15311.
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Angela M. Malek, Aaron Barchowsky, Robert Bowser, Ada Youk & Evelyn O. Talbott. (2012) Pesticide exposure as a risk factor for amyotrophic lateral sclerosis: A meta-analysis of epidemiological studies. Environmental Research 117, pages 112-119.
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Freya Kamel, David M. Umbach, Richard S. Bedlack, Marie Richards, Mary Watson, Michael C.R. Alavanja, Aaron Blair, Jane A. Hoppin, Silke Schmidt & Dale P. Sandler. (2012) Pesticide exposure and amyotrophic lateral sclerosis. NeuroToxicology 33:3, pages 457-462.
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Vasilis P. Androutsopoulos, Konstantinos Kanavouras & Aristidis M. Tsatsakis. (2011) Role of paraoxonase 1 (PON1) in organophosphate metabolism: Implications in neurodegenerative diseases. Toxicology and Applied Pharmacology 256:3, pages 418-424.
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James D Berry & Merit E Cudkowicz. (2011) New considerations in the design of clinical trials for amyotrophic lateral sclerosis. Clinical Investigation 1:10, pages 1375-1389.
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Claudia Ricci, Stefania Battistini, Lorena Cozzi, Michele Benigni, Paola Origone, Lorenzo Verriello, Christian Lunetta, Cristina Cereda, Pamela Milani, Giuseppe Greco, Maria Cristina Patrosso, Renzo Causarano, Claudia Caponnetto, Fabio Giannini, Massimo Corbo & Silvana Penco. (2011) Lack of association of PON polymorphisms with sporadic ALS in an Italian population. Neurobiology of Aging 32:3, pages 552.e7-552.e13.
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Karen Huen, Lisa Barcellos, Kenneth Beckman, Sherri Rose, Brenda Eskenazi & Nina Holland. (2011) Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children. Environmental and Molecular Mutagenesis 52:2, pages 105-116.
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Nicola Ticozzi, Ashley Lyn LeClerc, Pamela J. Keagle, Jonathan D. Glass, Anne‐Marie Wills, Marka van Blitterswijk, Daryl A. Bosco, Ildefonso Rodriguez‐Leyva, Cinzia Gellera, Antonia Ratti, Franco Taroni, Diane McKenna‐Yasek, Peter C. Sapp, Vincenzo Silani, Clement E. Furlong, Robert H. BrownJr.Jr. & John E. Landers. (2010) Paraoxonase gene mutations in amyotrophic lateral sclerosis. Annals of Neurology 68:1, pages 102-107.
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Dorota Zawiślak, Monika Ostrowska, Aleksandra Golenia, Monika Marona, Barbara Tomik, Paweł Wołkow, Elżbieta Gryz-Kurek, Andrzej Szczudlik & Agnieszka Słowik. (2010) The –A162G polymorphism of the PON1 gene and the risk of sporadic amyotrophic lateral sclerosis. Neurologia i Neurochirurgia Polska 44:3, pages 246-250.
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Binita Goswami, Devika Tayal, Nikhil Gupta & V. Mallika. (2009) Paraoxonase: A multifaceted biomolecule. Clinica Chimica Acta 410:1-2, pages 1-12.
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Frank O. Johnson & William D. Atchison. (2009) The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosis. NeuroToxicology 30:5, pages 761-765.
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Paul N. Valdmanis, Hussein Daoud, Patrick A. Dion & Guy A. Rouleau. (2009) Recent advances in the genetics of amyotrophic lateral sclerosis. Current Neurology and Neuroscience Reports 9:3, pages 198-205.
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