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Drug Profile

A pharmacological overview of lamotrigine for the treatment of epilepsy

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Pages 1533-1546 | Received 11 Jun 2016, Accepted 24 Oct 2016, Published online: 21 Nov 2016

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Sajeeda S, Lalit Kumar & Ruchi Verma. (2022) Lamotrigine—A Review of Analytical Methods Developed for Pharmaceutical Formulations and Biological Matrices. Critical Reviews in Analytical Chemistry 52:7, pages 1451-1460.
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Alessandra Morano, Luigi Iannone, Caterina Palleria, Martina Fanella, Anna Teresa Giallonardo, Giovambattista De Sarro, Emilio Russo & Carlo Di Bonaventura. (2019) Pharmacology of new and developing intravenous therapies for the management of seizures and epilepsy. Expert Opinion on Pharmacotherapy 20:1, pages 25-39.
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Lanyan Fang, Zhichuan Li, Minori Kinjo, Sara Lomonaco, Nan Zheng, Wenlei Jiang & Liang Zhao. (2022) Generic lamotrigine extended‐release tablets are bioequivalent to innovator drug in fully replicated crossover bioequivalence study. Epilepsia 64:1, pages 152-161.
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Nevin Tham & Sarah R. Langley. (2022) Evaluating the robustness of connectivity methods to noise for in silico drug repurposing studies. Frontiers in Systems Biology 2.
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Bhavatharini PA, Shri Sanghavi G, Grace Thomas & Arun KP. (2022) Dosage Optimization of Lamotrigine in Pregnancy: A Pharmacometric Approach Using Modeling and Simulation. The Journal of Clinical Pharmacology 62:12, pages 1557-1565.
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Qinghong Hou, Lulu Wang, Feng Xiao, Le Wang, Xiaoyan Liu, Lina Zhu, Yi Lu, Wenfu Zheng & Xingyu Jiang. (2022) Dual targeting nanoparticles for epilepsy therapy. Chemical Science 13:43, pages 12913-12920.
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Jiaquan Li, Yangjia Huang, Qi An, Wenyu Li, Jianting Li, Hongji Liu, Dezhi Yang, Yang Lu & Zhengzheng Zhou. (2022) Discovered two polymorphs and two solvates of lamotrigine-tolfenamic acid salt: Thermal behavior and crystal morphological differences. International Journal of Pharmaceutics 628, pages 122310.
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Xianjing Zhou, Linwei Zeng, Yi Wang, Cenglin Xu, Zhong Chen & Sunliang Cui. (2022) Discovery of triazenyl triazoles as Nav1.1 channel blockers for treatment of epilepsy. Bioorganic & Medicinal Chemistry Letters 75, pages 128946.
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N. M. Zhuravlev, N. A. Shnayder, E. E. Vaiman, A. K. Abdyrakhmanova, M. M. Petrova, E. N. Bochanova, I. V. Romanova, O. A. Gavrilyuk, N. V. Lareva & R. F. Nasyrova. (2022) Interindividual Variability of Anticonvulsant-Induced QT Prolongation Risk. Personalized Psychiatry and Neurology 2:1, pages 22-45.
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Maja Hochbaum, Ricardo Kienitz, Felix Rosenow, Juliane Schulz, Lena Habermehl, Lisa Langenbruch, Stjepana Kovac, Susanne Knake, Felix von Podewils, Sophie von Brauchitsch, Mario Hamacher, Adam Strzelczyk & Laurent M. Willems. (2022) Trends in antiseizure medication prescription patterns among all adults, women, and older adults with epilepsy: A German longitudinal analysis from 2008 to 2020. Epilepsy & Behavior 130, pages 108666.
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Aynaz Zarghampour, Milad Moradi, Elaheh Rahimpour, Fleming Martinez, Hongkun Zhao & Abolghasem Jouyban. (2021) Solubility study of lamotrigine in the aqueous mixture of choline chloride based deep eutectic solvent at different temperatures. Journal of Molecular Liquids 344, pages 117935.
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Shokufeh Bagheri, Rasool Haddadi, Sahar Saki, Masoumeh Kourosh‐Arami & Alireza Komaki. (2021) The effect of sodium channels on neurological/neuronal disorders: A systematic review. International Journal of Developmental Neuroscience 81:8, pages 669-685.
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Alexis S. McLaine, Page E. Yaxley, Anda A. Young & Edward S. Cooper. (2021) Successful management of massive lamotrigine extended‐release intoxication in a dog. Clinical Case Reports 9:12.
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Marta Karaźniewicz-Łada, Anna K. Główka, Aniceta A. Mikulska & Franciszek K. Główka. (2021) Pharmacokinetic Drug–Drug Interactions among Antiepileptic Drugs, Including CBD, Drugs Used to Treat COVID-19 and Nutrients. International Journal of Molecular Sciences 22:17, pages 9582.
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N. A. Shnayder, M. M. Petrova, K. V. Petrov & R. F. Nasyrova. (2021) Pharmacological predictors of heart rate and conductivity disorders in juvenile myoclonic epilepsy. Epilepsy and paroxysmal conditions 13:2, pages 168-179.
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Shruthi Shankar RamanVedha Hari B NarayananRamyadevi Durai. (2021) Lamotrigine Nanoparticle Laden Polymer Composite Oral Dissolving Films for Improving Therapeutic Potential of the Hydrophobic Antiepileptic Molecule. ASSAY and Drug Development Technologies 19:1, pages 2-16.
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Karina Sommerfeld-Klatta, Barbara Zielińska-Psuja, Marta Karaźniewcz-Łada & Franciszek K. Główka. (2020) New Methods Used in Pharmacokinetics and Therapeutic Monitoring of the First and Newer Generations of Antiepileptic Drugs (AEDs). Molecules 25:21, pages 5083.
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Cinthya Eloisa Chávez-Castillo, Susanna Edith Medellín-Garibay, Rosa del Carmen Milán-Segovia, Ildefonso Rodríguez-Leyva & Silvia Romano-Moreno. (2020) Dosing Recommendations Based on Population Pharmacokinetics of Lamotrigine in Mexican Adult Patients With Epilepsy. Journal of Pharmaceutical Sciences 109:9, pages 2902-2908.
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Laurent M. Willems, Sebastian Bauer, Kolja Jahnke, Martin Voss, Felix Rosenow & Adam Strzelczyk. (2020) Therapeutic Options for Patients with Refractory Status Epilepticus in Palliative Settings or with a Limitation of Life-Sustaining Therapies: A Systematic Review. CNS Drugs 34:8, pages 801-826.
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José Eduardo Juárez-Hernández, Michel Gutiérrez-Ceniceros, José Rodrigo González-Ramírez, Mara Medeiros, Bruce Carleton, Colin Ross & Gilberto Castañeda-Hernández. (2020) Pharmacokinetic-Pharmacogenomic Model for Chinese Children treated with Lamotrigine also Applies for Mexican Children. Therapeutic Drug Monitoring Publish Ahead of Print.
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Peter S. Talbot. 2020. Seminars in Clinical Psychopharmacology. Seminars in Clinical Psychopharmacology 362 391 .
Zhao Zhang, Xia Zhou, Jinping Liu, Lu Qin, Lu Yu, Xiaomin Pang, Wei Ye & Jinou Zheng. (2020) Longitudinal assessment of resting-state fMRI in temporal lobe epilepsy: A two-year follow-up study. Epilepsy & Behavior 103, pages 106858.
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Amitava Dasgupta & Matthew D. Krasowski. 2020. Therapeutic Drug Monitoring Data. Therapeutic Drug Monitoring Data 99 158 .
Fenglai Xiao, Matthias J. Koepp & Dong Zhou. (2019) Pharmaco-fMRI: A Tool to Predict the Response to Antiepileptic Drugs in Epilepsy. Frontiers in Neurology 10.
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Ye Ding, Xiaoping Tan, Shuo Zhang & Yang Guo. (2019) Pharmacokinetic changes and therapeutic drug monitoring of lamotrigine during pregnancy. Brain and Behavior 9:7.
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Xiaonian Han, Jing Huang, Jianhua Lv, Li Ma, Lirong Peng, Jinping Wang, Xiaojing Nie, Li Xia & Xin Zan. (2019) The influence of concomitant antiepileptic drugs on lamotrigine serum concentrations in Northwest Chinese Han population with epilepsy. PLOS ONE 14:1, pages e0210600.
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Alessandro Galgani, Caterina Palleria, Luigi Francesco Iannone, Giovambattista De Sarro, Filippo Sean Giorgi, Marta Maschio & Emilio Russo. (2018) Pharmacokinetic Interactions of Clinical Interest Between Direct Oral Anticoagulants and Antiepileptic Drugs. Frontiers in Neurology 9.
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Sandra Ventura, Márcio Rodrigues, Amílcar Falcão & Gilberto Alves. (2018) Evaluation of the effects of Citrus aurantium (bitter orange) extract on lamotrigine pharmacokinetics: Insights from in vivo studies in rats. Food and Chemical Toxicology 121, pages 166-172.
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Tianbo Li & Jun Chen. 2018. Ion Channels in Health and Sickness. Ion Channels in Health and Sickness.
Marta Vázquez, Cecilia Maldonado, Natalia Guevara, Andrea Rey, Pietro Fagiolino, Antonella Carozzi & Carlos Azambuja. (2018) Lamotrigine-Valproic Acid Interaction Leading to Stevens–Johnson Syndrome. Case Reports in Medicine 2018, pages 1-5.
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Mortaza Iranifam, Nasim Rahmati Hendekhale & Haider A. J. Al Lawati. (2018) The Co 3 O 4 nanoparticle-enhanced luminol-O 2 chemiluminescence reaction used for the determination of nortriptyline hydrochloride and lamotrigine in pharmaceutical and environmental samples . Analytical Methods 10:4, pages 429-438.
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Kuldeep Kumar Namdev, Jaya Dwivedi, Deepak Chandra Chilkoti & Swapnil Sharma. (2018) A simple, rapid and stability indicating validated method for quantification of lamotrigine in human plasma and dry plasma spot using LC-ESI–MS/MS: Application in clinical study. Journal of Chromatography B 1072, pages 362-369.
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Chung-Ying Lin, Xavier C.C. Fung, Mehdi Nikoobakht, Andrea Burri & Amir H. Pakpour. (2017) Using the Theory of Planned Behavior incorporated with perceived barriers to explore sexual counseling services delivered by healthcare professionals in individuals suffering from epilepsy. Epilepsy & Behavior 74, pages 124-129.
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Rocco Salvatore Calabrò. (2017) Lamotrigine-induced persistent genital arousal disorder: An unusual side effect. Epilepsy & Behavior 68, pages 234-235.
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