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Expert Review of Clinical Pharmacology Volume 10, 2017 - Issue 1
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Review

Paracetamol and morphine for infant and neonatal pain; still a long way to go?

Manuel A. BaarslagIntensive Care and department of Pediatric Surgery, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the NetherlandsCorrespondence[email protected]
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Karel AllegaertIntensive Care and department of Pediatric Surgery, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands;Department of development and regeneration, KU Leuven, Leuven, BelgiumView further author information
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John N. Van Den AnkerIntensive Care and department of Pediatric Surgery, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands;Division of Clinical Pharmacology, Children’s National Health System, Washington, DC, USA;Division of Pediatric Pharmacology and Pharmacometrics, University of Basel Children’s Hospital, Basel, SwitzerlandView further author information
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Catherijne A.J. KnibbeDepartment of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands;Division of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, the NetherlandsView further author information
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Monique Van DijkIntensive Care and department of Pediatric Surgery, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands;Department of Pediatrics, division of Neonatology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the NetherlandsView further author information
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Sinno H.P. SimonsDepartment of Pediatrics, division of Neonatology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the NetherlandsView further author information
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Dick TibboelIntensive Care and department of Pediatric Surgery, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the NetherlandsView further author information
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Pages 111-126 | Received 14 Jun 2016, Accepted 25 Oct 2016, Published online: 09 Nov 2016

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Mariëlle Eerdekens, Christoph Beuter, Claudia Lefeber & John van den Anker. (2019) The challenge of developing pain medications for children: therapeutic needs and future perspectives. Journal of Pain Research 12, pages 1649-1664.
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Chiara Locatelli & Carlo Valerio Bellieni. (2018) Sensorial saturation and neonatal pain: a review. The Journal of Maternal-Fetal & Neonatal Medicine 31:23, pages 3209-3213.
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Tamara Van Donge, Paola Mian, Dick Tibboel, John Van Den Anker & Karel Allegaert. (2018) Drug metabolism in early infancy: opioids as an illustration. Expert Opinion on Drug Metabolism & Toxicology 14:3, pages 287-301.
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Hana Cihlarova, Lenka Bencova, Blanka Zlatohlavkova, Karel Allegaert & Pavla Pokorna. (2022) Rescue Paracetamol in Postoperative Pain Management in Extremely Low Birth Weight Neonates Following Abdominal Surgery: A Single Unit Retrospective Study. Frontiers in Pediatrics 10.
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Amir M. Zayegh. (2022) Addressing Suffering in Infants and Young Children Using the Concept of Suffering Pluralism. Journal of Bioethical Inquiry 19:2, pages 203-212.
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Caroline Hartley. (2021) Toward personalized medicine for pharmacological interventions in neonates using vital signs. Paediatric and Neonatal Pain 3:4, pages 147-155.
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Pavla Pokorna & Dick Tibboel. (2020) Numbers, Numbers: Great, Great…But?!*. Pediatric Critical Care Medicine 21:9, pages 844-845.
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Xu Zhili, Chen Linglong, Jin Shuang & Yang Baohua. (2020) Comparing the analgesic effect of intravenous paracetamol with morphine on patients with renal colic pain: A meta-analysis of randomized controlled studies. The American Journal of Emergency Medicine 38:7, pages 1470-1474.
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Alexander A. Vinks, Nieko C. Punt, Frank Menke, Eric Kirkendall, Dawn Butler, Thomas J. Duggan, DonnaMaria E. Cortezzo, Sam Kiger, Tom Dietrich, Paul Spencer, Rob Keefer, Kenneth D.R. Setchell, Junfang Zhao, Joshua C. Euteneuer, Tomoyuki Mizuno & Kevin R. Dufendach. (2019) Electronic Health Record–Embedded Decision Support Platform for Morphine Precision Dosing in Neonates. Clinical Pharmacology & Therapeutics 107:1, pages 186-194.
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Jamesia Donato, Karishma Rao & Tamorah Lewis. (2019) Pharmacology of Common Analgesic and Sedative Drugs Used in the Neonatal Intensive Care Unit. Clinics in Perinatology 46:4, pages 673-692.
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Deniz Gursul, Caroline Hartley & Rebeccah Slater. (2019) Nociception and the neonatal brain. Seminars in Fetal and Neonatal Medicine 24:4, pages 101016.
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Laurent M. A. Favié, Floris Groenendaal, Marcel P. H. van den Broek, Carin M. A. Rademaker, Timo R. de Haan, Henrica L. M. van Straaten, Peter H. Dijk, Arno van Heijst, Jeroen Dudink, Koen P. Dijkman, Monique Rijken, Inge A. Zonnenberg, Filip Cools, Alexandra Zecic, Johanna H. van der Lee, Debbie H. G. M. Nuytemans, Frank van Bel, Toine C. G. Egberts & Alwin D. R. Huitema. (2019) Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia. PLOS ONE 14:2, pages e0211910.
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Fiona Moultrie, Adam Shriver, Caroline Hartley, Dominic Wilkinson, Andrew K Ewer, Richard Rogers, Eleri Adams & Rebeccah Slater. (2019) A universal right to pain relief: balancing the risks in a vulnerable patient population. The Lancet Child & Adolescent Health 3:2, pages 62-64.
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Caroline Hartley, Fiona Moultrie, Amy Hoskin, Gabrielle Green, Vaneesha Monk, Jennifer L Bell, Andrew R King, Miranda Buckle, Marianne van der Vaart, Deniz Gursul, Sezgi Goksan, Edmund Juszczak, Jane E Norman, Richard Rogers, Chetan Patel, Eleri Adams & Rebeccah Slater. (2018) Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial. The Lancet 392:10164, pages 2595-2605.
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R.M. Schiller, K. Allegaert, Maayke Hunfeld, G.E. van den Bosch, John van den Anker & D. Tibboel. (2018) Analgesics and Sedatives in Critically Ill Newborns and Infants: The Impact on Long-Term Neurodevelopment. The Journal of Clinical Pharmacology 58, pages S140-S150.
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M. Richter & B. Seipolt. (2018) Schmerztherapie bei Früh- und NeugeborenenPain therapy for premature babies and neonates. Monatsschrift Kinderheilkunde 166:9, pages 823-834.
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M. Richter & B. Seipolt. (2018) Schmerztherapie bei Früh- und NeugeborenenPain therapy for premature babies and neonates. Der Schmerz 32:2, pages 153-164.
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Sebastiaan C. Goulooze, Elke H.J. Krekels, Monique van Dijk, Dick Tibboel, Piet H. van der Graaf, Thomas Hankemeier, Catherijne A.J. Knibbe & J.G. Coen van Hasselt. (2017) Towards personalized treatment of pain using a quantitative systems pharmacology approach. European Journal of Pharmaceutical Sciences 109, pages S32-S38.
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Fiona Moultrie, Rebeccah Slater & Caroline Hartley. (2017) Improving the treatment of infant pain. Current Opinion in Supportive & Palliative Care 11:2, pages 112-117.
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