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Omega-3 polyunsaturated fatty acids for cardiovascular diseases: present, past and future

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Pages 865-873 | Received 31 Mar 2017, Accepted 19 May 2017, Published online: 29 May 2017

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Nicholas L. DePace & Joseph ColomboNicholas L. DePace & Joseph Colombo. 2019. Clinical Autonomic and Mitochondrial Disorders. Clinical Autonomic and Mitochondrial Disorders 37 70 .
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Crossref
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Crossref
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Crossref
Suzanne Ostrand-Rosenberg. (2018) Myeloid derived-suppressor cells: their role in cancer and obesity. Current Opinion in Immunology 51, pages 68-75.
Crossref
Ramón Cacabelos, Valter Lombardi, Lucía Fernández-Novoa, Iván Carrera, Pablo Cacabelos, Lola Corzo, Juan C. Carril & Oscar Teijido. 2018. 195 225 .
Lara Costantini, Romina Molinari, Barbara Farinon & Nicolò Merendino. (2017) Impact of Omega-3 Fatty Acids on the Gut Microbiota. International Journal of Molecular Sciences 18:12, pages 2645.
Crossref
Matteo Manuelli, Lucio Della Guardia & Hellas Cena. (2017) Enriching Diet with n-3 PUFAs to Help Prevent Cardiovascular Diseases in Healthy Adults: Results from Clinical Trials. International Journal of Molecular Sciences 18:7, pages 1552.
Crossref

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