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Review

A resurging boom in new drugs for epilepsy and brain disorders

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Pages 27-45 | Received 08 Aug 2017, Accepted 27 Sep 2017, Published online: 23 Oct 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Kahkashan Afrin, Revanth Dusi, Yuhao Zhong, D. Samba Reddy & Satish T. S. Bukkapatnam. (2022) Prognosis of Epileptic Seizure Event Onsets Using Random Survival Forests. IISE Transactions on Healthcare Systems Engineering 12:3, pages 221-231.
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Simona Lattanzi, Antonella Riva & Pasquale Striano. (2021) Ganaxolone treatment for epilepsy patients: from pharmacology to place in therapy. Expert Review of Neurotherapeutics 21:11, pages 1317-1332.
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Adam Strzelczyk, Catrin Mann, Laurent M. Willems, Felix Rosenow & Sebastian Bauer. (2020) Cenobamate for the treatment of focal epilepsies. Expert Opinion on Pharmacotherapy 21:18, pages 2215-2223.
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Stefano de Biase, Annacarmen Nilo, Andrea Bernardini, Gian Luigi Gigli, Mariarosaria Valente & Giovanni Merlino. (2019) Timing use of novel anti-epileptic drugs: is earlier better?. Expert Review of Neurotherapeutics 19:10, pages 945-954.
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Laureano L. Sabatier, Pablo H. Palestro, Andrea V. Enrique, Valentina Pastore, María L. Sbaraglini, Pedro Martín & Luciana Gavernet. (2019) Design, synthesis and biological evaluation of N-substituted α-hydroxyimides and 1,2,3-oxathiazolidine-4-one-2,2-dioxides with anticonvulsant activity. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1465-1473.
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Marco Greco, Gaia Varriale, Giangennaro Coppola, Francesca Operto, Alberto Verrotti & Maria Laura Iezzi. (2018) Investigational small molecules in phase II clinical trials for the treatment of epilepsy. Expert Opinion on Investigational Drugs 27:12, pages 971-979.
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Articles from other publishers (40)

Tafere Mulaw Belete. (2023) Recent Progress in the Development of New Antiepileptic Drugs with Novel Targets. Annals of Neurosciences 30:4, pages 262-276.
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Doodipala Samba Reddy, Robert H. Mbilinyi & Emily Estes. (2023) Preclinical and clinical pharmacology of brexanolone (allopregnanolone) for postpartum depression: a landmark journey from concept to clinic in neurosteroid replacement therapy. Psychopharmacology 240:9, pages 1841-1863.
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Doodipala Samba Reddy. (2023) Building evidence on therapeutic efficacy and innovative mechanisms of cannabinoids in neurological disorders. Experimental Neurology 364, pages 114390.
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Edson Fernando Muller Guzzo, Gabriel de Lima Rosa, Amanda Muliterno Domingues, Rafael Bremm Padilha & Adriana Simon Coitinho. (2023) Reduction of seizures and inflammatory markers by betamethasone in a kindling seizure model. Steroids 193, pages 109202.
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Susan J. Keam & Zaina T. Al-Salama. (2023) Ganaxolone in seizures associated with cyclin-dependent kinase-like 5 deficiency disorder: a profile of its use in the USA. Drugs & Therapy Perspectives 39:3, pages 81-88.
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Danielle S. Abraham, Thanh Phuong Pham Nguyen, Leah J. Blank, Dylan Thibault, Shelly L. Gray, Sean Hennessy, Charles E. Leonard, Daniel Weintraub & Allison W. Willis. (2023) Channeling of New Neuropsychiatric Drugs—Impact on Safety and Effectiveness Studies. Neurotherapeutics 20:2, pages 375-388.
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Doodipala Samba Reddy. (2023) Therapeutic and clinical foundations of cannabidiol therapy for difficult-to-treat seizures in children and adults with refractory epilepsies. Experimental Neurology 359, pages 114237.
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Doodipala Samba Reddy. 2023. Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects. Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects 489 500 .
Persefoni Ioannou, Daniella L. Foster, Josemir W. Sander, Sophie Dupont, Antonio Gil‐Nagel, Ewa Drogon O'Flaherty, Elena Alvarez‐Baron & Jasmina Medjedovic. (2022) The burden of epilepsy and unmet need in people with focal seizures. Brain and Behavior 12:9.
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Ida Stenshorne, Marte Syvertsen, Anette Ramm-Pettersen, Susanne Henning, Elisabeth Weatherup, Alf Bjørnstad, Natalia Brüggemann, Torstein Spetalen, Kaja K. Selmer & Jeanette Koht. (2022) Monogenic developmental and epileptic encephalopathies of infancy and childhood, a population cohort from Norway. Frontiers in Pediatrics 10.
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Shengying Lou & Sunliang Cui. (2022) Drug Treatment of Epilepsy: From Serendipitous Discovery to Evolutionary Mechanisms. Current Medicinal Chemistry 29:19, pages 3366-3391.
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Tomohiko Murakami, Yuri Nakaminami, Yoshifumi Takahata, Kenji Hata & Riko Nishimura. (2022) Activation and Function of NLRP3 Inflammasome in Bone and Joint-Related Diseases. International Journal of Molecular Sciences 23:10, pages 5365.
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Mayuri Shukla, Prapimpun Wongchitrat & Piyarat Govitrapong. (2022) A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies–Emphasis on Alzheimer’s Disease Pathogenesis. Neurochemical Research 47:5, pages 1166-1182.
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Doodipala Samba Reddy. (2021) Neurosteroid replacement therapy for catamenial epilepsy, postpartum depression and neuroendocrine disorders in women. Journal of Neuroendocrinology 34:2.
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Wenju Liu, Junwei Shen, Yanfei Li, Jiawen Wu, Xiaoli Luo, Yuanyuan Yu, Yuhan Zhang, Liang Gu, Xiaobai Zhang, Cizhong Jiang & Jue Li. (2021) Pyroptosis inhibition improves the symptom of acute myocardial infarction. Cell Death & Disease 12:10.
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Yang-Ming Zhang, Hai-Yan Xu, Hai-Ning Hu, Fu-Yun Tian, Fei Chen, Hua-Nan Liu, Li Zhan, Xiao-Ping Pi, Jie Liu, Zhao-Bing Gao & Fa-Jun Nan. (2021) Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate. Journal of Medicinal Chemistry 64:9, pages 5816-5837.
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Felix Chan & Judy Liu. (2021) Molecular regulation of brain metabolism underlying circadian epilepsy. Epilepsia 62:S1.
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Detlev Boison. 2021. Inflammation and Epilepsy: New Vistas. Inflammation and Epilepsy: New Vistas 185 201 .
T. Pooventhiran, Utsab Bhattacharyya, D. Jagadeeswara Rao, Vivek Chandramohan, Prashantha Karunakar, Ahmad Irfan, Y. Sheena Mary & Renjth Thomas. (2020) Detailed spectra, electronic properties, qualitative non-covalent interaction analysis, solvatochromism, docking and molecular dynamics simulations in different solvent atmosphere of cenobamate. Structural Chemistry 31:6, pages 2475-2485.
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Tomohiko Murakami, Yoshifumi Takahata, Kenji Hata & Riko Nishimura. (2020) Role of interleukin-1 and inflammasomes in oral disease. Journal of Oral Biosciences.
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Lanxin Luo, Jun Wang, Dawei Ding, Md Nabiul Hasan, Sung-Sen Yang, Shih-Hua Lin, Philipp Schreppel, Baoshan Sun, Yan Yin, Thomas Erker & Dandan Sun. (2020) Role of NKCC1 Activity in Glioma K+ Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66. Frontiers in Physiology 11.
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Landen Weltha, Jesica Reemmer & Detlev Boison. (2019) The role of adenosine in epilepsy. Brain Research Bulletin 151, pages 46-54.
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Dorothee G.A. Kasteleijn- Nolst TreniteBree D. DiVenturaJohn R. PollardGregory L. KraussSarah MizneJacqueline A. French. (2019) Suppression of the photoparoxysmal response in photosensitive epilepsy with cenobamate (YKP3089). Neurology 93:6.
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Shu-Hui Chuang & Doodipala Samba Reddy. (2019) Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus. Neuropharmacology 148, pages 244-256.
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Doodipala Samba Reddy. (2019) Mechanism-based novel antidotes for organophosphate neurotoxicity. Current Opinion in Toxicology 14, pages 35-45.
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