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Expert Review of Clinical Pharmacology Volume 14, 2021 - Issue 4
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Meta-analysis

Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis

Anuraag Jenaa Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaORCID Iconhttps://orcid.org/0000-0001-9074-6698View further author information
ORCID Icon,
Daya Krishna Jhaa Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaView further author information
,
Praveen Kumar-Mb Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaORCID Iconhttps://orcid.org/0000-0002-9318-1167View further author information
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Kripa Shanker Kasudhanb Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaView further author information
,
Ankit Kumarb Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaView further author information
,
Dhruv Sarwalc Government Medical College and hospital- Sector 32, Ex-intern, Chandigarh, IndiaORCID Iconhttps://orcid.org/0000-0002-6253-6236View further author information
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Shubhra Mishraa Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaORCID Iconhttps://orcid.org/0000-0002-8048-9760View further author information
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Anupam Kumar Singha Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaORCID Iconhttps://orcid.org/0000-0002-7610-1807View further author information
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Prateek Bhatiad Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaView further author information
,
Amol Patilb Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaORCID Iconhttps://orcid.org/0000-0001-8552-2796View further author information
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Vishal Sharmaa Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2472-3409View further author information
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Pages 491-501 | Received 07 Jan 2021, Accepted 02 Mar 2021, Published online: 15 Mar 2021

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Anuraag Jena, Chhagan L Birda, Arup Choudhury & Vishal Sharma. (2023) Safety and efficacy of personalized versus standard initial dosing of thiopurines: Systematic review and meta-analysis of randomized trials. Expert Opinion on Drug Safety 0:0, pages 1-11.
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Devendra Desai, Anuraag Jena, Vishal Sharma & Toshifumi Hibi. (2023) Time to incorporate preemptive NUDT15 testing before starting thiopurines in inflammatory bowel disease in Asia and beyond: a review. Expert Review of Clinical Pharmacology 16:7, pages 643-653.
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Debbie S. Deben, Dennis R. Wong & Adriaan A. van Bodegraven. (2021) Current status and future perspectives on the use of therapeutic drug monitoring of thiopurine metabolites in patients with inflammatory bowel disease. Expert Opinion on Drug Metabolism & Toxicology 17:12, pages 1433-1444.
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Articles from other publishers (13)

Marta Gutiérrez-Valencia, Leire LeacheLuis Carlos SaizJuan J. Beloqui, Miguel Barajas, Miren Vicuña & Juan Erviti. (2023) Role of Pharmacogenomics in the Efficacy and Safety of Thiopurines in Inflammatory Bowel Disease. Journal of Clinical Gastroenterology 57:7, pages 671-685.
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Anuraag Jena, Pardhu B Neelam, Harshavardhan Telaprolu, Uday Kiran Mangipudi, Usha Dutta, Shaji Sebastian & Vishal Sharma. (2023) Effectiveness and safety of thioguanine as a maintenance therapy of inflammatory bowel disease: Systematic review, meta-analysis and meta-regression. Clinics and Research in Hepatology and Gastroenterology 47:7, pages 102155.
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Natalie Yu, Danujan Sriranganathan, Gareth J Walker, Aleksejs Sazonovs, Helen Wilding, Christopher Roberts, Nicholas A Kennedy, Tariq Ahmad, Ray K Boyapati, Nik S Ding & Jonathan P Segal. (2023) Prevalence of NUDT15 Genetic Variants and Incidence of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis . Journal of Crohn's and Colitis.
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Mai-Lan Nguyen, Anh Vu Hoang, Bich Tram Duong & Nguyen The Nguyen Phung. (2023) The influence of NUDT15 variants on 6-mercaptopurine-induced neutropenia in Vietnamese pediatric acute lymphoblastic leukemia. Human Genetics and Genomics Advances 4:2, pages 100183.
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A. Jena, N. Grover, P. Bhatia, M. Singh, D. Lad, K.K. Prasad, H. Singh, U. Dutta & V. Sharma. (2023) ITPA polymorphisms do not predict additional risk beyond TPMT and NUDT15 for thiopurine-induced cytopenia in inflammatory bowel disease. Revista de Gastroenterología de México (English Edition).
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Vishal Sharma, Saurabh Kedia & Vineet Ahuja. (2022) Personalized medicine to implementation science: Thiopurines set for the leap. JGH Open 6:10, pages 651-657.
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Heh-Shiang Sheu, Yi-Ming Chen, Yi-Ju Liao, Chia-Yi Wei, Jun-Peng Chen, Hsueh-Ju Lin, Wei-Ting Hung, Wen-Nan Huang & Yi-Hsing Chen. (2022) Thiopurine S-Methyltransferase Polymorphisms Predict Hepatotoxicity in Azathioprine-Treated Patients with Autoimmune Diseases. Journal of Personalized Medicine 12:9, pages 1399.
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Mukesh Kumar Ranjan, Bhaskar Kante, Sudheer Kumar Vuyyuru, Peeyush Kumar, Sandeep K Mundhra, Rithvik Golla, Raju Sharma, Peush Sahni, Prasenjit Das, Govind Makharia, Saurabh Kedia & Vineet Ahuja. (2022) Minimal risk of lymphoma and non‐melanoma skin cancer despite long‐term use of thiopurines in patients with inflammatory bowel disease: A longitudinal cohort analysis from northern India. Journal of Gastroenterology and Hepatology 37:8, pages 1544-1553.
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A. Jena, N. Grover, P. Bhatia, M. Singh, D. Lad, K.K. Prasad, H. Singh, U. Dutta & V. Sharma. (2022) Los polimorfismos de ITPA no predicen un riesgo adicional más allá de TPMT y NUDT15 para citopenia inducida por tiopurina en la enfermedad inflamatoria intestinal. Revista de Gastroenterología de México.
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Ahmad Al Bishawi, Shiema Abdalla, Marwa Askar, Wael Kanjo, Amal Sameer, Gihan Mustafa, Hamad Abdel Hadi, Muna Al Maslamani & Alaaeldin Abdelmajid. (2022) Dilemma of Tocilizumab therapy for a patient with critical COVID‐19 disease and neutropenia: Case report and review of the literature. Clinical Case Reports 10:5.
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Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta & Vishal Sharma. (2021) TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India. BMC Gastroenterology 21:1.
Crossref
Amit Yadav, Anuraag Jena, Rozy Thakur, Pankaj Kumar, Prateek Bhatia & Vishal Sharma. (2021) Fatal thiopurine toxicity: pre-emptive testing of NUDT15 415C > T polymorphism may be life saving in South Asian population . Drug Metabolism and Personalized Therapy 36:4, pages 351-352.
Crossref
Amit Yadav, Anuraag Jena, Rozy Thakur, Pankaj Kumar, Prateek Bhatia & Vishal Sharma. (2021) Fatal thiopurine toxicity: pre-emptive testing of NUDT15 415C > T polymorphism may be life saving in South Asian population . Drug Metabolism and Personalized Therapy 0:0.
Crossref

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