1,896
Views
59
CrossRef citations to date
0
Altmetric
Short Communication

Prion aggregates transfer through tunneling nanotubes in endocytic vesicles

, , , &
Pages 125-135 | Received 30 Nov 2014, Accepted 26 Feb 2015, Published online: 21 May 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Elena De Cecco & Giuseppe Legname. (2018) The role of the prion protein in the internalization of α-synuclein amyloids. Prion 12:1, pages 23-27.
Read now
Saida Abounit, Jessica W. Wu, Karen Duff, Guiliana Soraya Victoria & Chiara Zurzolo. (2016) Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases. Prion 10:5, pages 344-351.
Read now

Articles from other publishers (57)

Reinhold Nafe, Christophe T. Arendt & Elke Hattingen. (2023) Human prion diseases and the prion protein – what is the current state of knowledge?. Translational Neuroscience 14:1.
Crossref
Luigi Celauro, Marco Zattoni & Giuseppe Legname. 2023. Receptor Endocytosis And Signalling In Health And Disease - Part B. Receptor Endocytosis And Signalling In Health And Disease - Part B 15 41 .
Lilin Huang, Jiao Zhang, Zekai Wu, Liangliang Zhou, Bin Yu, Yingying Jing, Danying Lin & Junle Qu. (2022) Revealing the structure and organization of intercellular tunneling nanotubes (TNTs) by STORM imaging. Nanoscale Advances 4:20, pages 4258-4262.
Crossref
Kirby M. Donnelly, Cevannah M. Coleman, Madison L. Fuller, Victoria L. Reed, Dayna Smerina, David S. Tomlinson & Margaret M. Panning Pearce. (2022) Hunting for the cause: Evidence for prion-like mechanisms in Huntington’s disease. Frontiers in Neuroscience 16.
Crossref
Sarita Lagalwar. (2022) Mechanisms of tunneling nanotube-based propagation of neurodegenerative disease proteins. Frontiers in Molecular Neuroscience 15.
Crossref
Laura Turos-Korgul, Marta Dorota Kolba, Piotr Chroscicki, Aleksandra Zieminska & Katarzyna Piwocka. (2022) Tunneling Nanotubes Facilitate Intercellular Protein Transfer and Cell Networks Function. Frontiers in Cell and Developmental Biology 10.
Crossref
Julia Driscoll, Piyush Gondaliya & Tushar Patel. (2022) Tunneling Nanotube-Mediated Communication: A Mechanism of Intercellular Nucleic Acid Transfer. International Journal of Molecular Sciences 23:10, pages 5487.
Crossref
Haoyang Huang, Nicholas Toker, Eliza Burr, Jeff Okoro, Maia Moog, Casey Hearing & Sarita Lagalwar. (2021) Intercellular Propagation and Aggregate Seeding of Mutant Ataxin-1. Journal of Molecular Neuroscience 72:4, pages 708-718.
Crossref
Stefanie-Elisabeth Heumüller, Annika C. Hornberger, Alina S. Hebestreit, André Hossinger & Ina M. Vorberg. (2022) Propagation and Dissemination Strategies of Transmissible Spongiform Encephalopathy Agents in Mammalian Cells. International Journal of Molecular Sciences 23:6, pages 2909.
Crossref
Khattar E. Khattar, Janice Safi, Anne-Marie Rodriguez & Marie-Luce Vignais. (2022) Intercellular Communication in the Brain through Tunneling Nanotubes. Cancers 14:5, pages 1207.
Crossref
Sunayana Dagar, Diksha Pathak, Harsh V. Oza & Sivaram V. S. Mylavarapu. (2021) Tunneling nanotubes and related structures: molecular mechanisms of formation and function. Biochemical Journal 478:22, pages 3977-3998.
Crossref
Jing Chen & Junyan Cao. (2021) Astrocyte-to-neuron transportation of enhanced green fluorescent protein in cerebral cortex requires F-actin dependent tunneling nanotubes. Scientific Reports 11:1.
Crossref
Xiao-Tong Wang, Hua Sun, Nai-Hong Chen & Yu-He Yuan. (2021) Tunneling nanotubes: A novel pharmacological target for neurodegenerative diseases?. Pharmacological Research 170, pages 105541.
Crossref
Fei Wang, Xiaoping Chen, Haipeng Cheng, Lu Song, Jianghong Liu, Steve Caplan, Li Zhu & Jane Y Wu. (2021) MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking. EMBO reports 22:7.
Crossref
Diégo Cordero Cervantes & Chiara Zurzolo. (2021) Peering into tunneling nanotubes—The path forward. The EMBO Journal 40:8.
Crossref
Gal Haimovich, Sandipan Dasgupta & Jeffrey E. Gerst. (2021) RNA transfer through tunneling nanotubes. Biochemical Society Transactions 49:1, pages 145-160.
Crossref
Giulia Pinto, Inés Saenz-de-Santa-Maria, Patricia Chastagner, Emeline Perthame, Caroline Delmas, Christine Toulas, Elizabeth Moyal-Jonathan-Cohen, Christel Brou & Chiara Zurzolo. (2021) Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids. Biochemical Journal 478:1, pages 21-39.
Crossref
Rodrigo Nunes Alves, Rebeca Piatniczka Iglesia, Mariana Brandão Prado, Maria Isabel Melo Escobar, Jacqueline Marcia Boccacino, Camila Felix de Lima Fernandes, Bárbara Paranhos Coelho, Ailine Cibele Fortes & Marilene Hohmuth Lopes. (2020) A New Take on Prion Protein Dynamics in Cellular Trafficking. International Journal of Molecular Sciences 21:20, pages 7763.
Crossref
Shaarvari Bhat, Nina Ljubojevic, Seng Zhu, Mitsunori Fukuda, Arnaud Echard & Chiara Zurzolo. (2020) Rab35 and its effectors promote formation of tunneling nanotubes in neuronal cells. Scientific Reports 10:1.
Crossref
Jessica Tittelmeier, Eliana Nachman & Carmen Nussbaum-Krammer. (2020) Molecular Chaperones: A Double-Edged Sword in Neurodegenerative Diseases. Frontiers in Aging Neuroscience 12.
Crossref
Giulia Pinto, Christel Brou & Chiara Zurzolo. (2020) Tunneling Nanotubes: The Fuel of Tumor Progression?. Trends in Cancer 6:10, pages 874-888.
Crossref
Alexander Tishchenko, Daniel D. Azorín, Laia Vidal-Brime, María José Muñoz, Pol Jiménez Arenas, Christopher Pearce, Henrique Girao, Santiago Ramón y Cajal & Trond Aasen. (2020) Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells. Cancers 12:10, pages 2798.
Crossref
Casey J. Latario, Lori W. Schoenfeld, Charles L. Howarth, Laura E. Pickrell, Fatema Begum, Dawn A. Fischer, Olivera Grbovic-Huezo, Steven D. Leach, Yolanda Sanchez, Kerrington D. Smith & Henry N. Higgs. (2020) Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner. Molecular Biology of the Cell 31:12, pages 1259-1272.
Crossref
Srinivasa Subramaniam. (2020) Rhes Tunnels: A Radical New Way of Communication in the Brain's Striatum?. BioEssays 42:6, pages 1900231.
Crossref
Bradley R. Groveman, Simote T. Foliaki, Christina D. Orru, Gianluigi Zanusso, James A. Carroll, Brent Race & Cathryn L. Haigh. (2019) Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids. Acta Neuropathologica Communications 7:1.
Crossref
Carla Neves Machado, Leonor Orge, Isabel Pires, Adelina Gama, Alexandra Esteves, Ana Paula Mendonça, Ana Matos, Anabela Alves, Carla Lima, Estela Bastos, Fernanda Seixas, Filipe Silva, João Carlos Silva, Luis Figueira, Madalena Vieira-Pinto, Maria De Lurdes Pinto, Nuno Gonçalves-Anjo, Paula Tavares, Paulo Carvalho, Roberto Sargo & Maria Dos Anjos Pires. 2019. Wildlife Population Monitoring. Wildlife Population Monitoring.
Mitja Drab, David Stopar, Veronika Kralj-Iglič & Aleš Iglič. (2019) Inception Mechanisms of Tunneling Nanotubes. Cells 8:6, pages 626.
Crossref
Aysegul Dilsizoglu Senol, Anna Pepe, Clara Grudina, Nathalie Sassoon, Ueoka Reiko, Luc Bousset, Ronald Melki, Jörn Piel, Muriel Gugger & Chiara Zurzolo. (2019) Effect of tolytoxin on tunneling nanotube formation and function. Scientific Reports 9:1.
Crossref
Rahul Mittal, Elisa Karhu, Jay‐Shing Wang, Stefanie Delgado, Ryan Zukerman, Jeenu Mittal & Vasanti M. Jhaveri. (2018) Cell communication by tunneling nanotubes: Implications in disease and therapeutic applications. Journal of Cellular Physiology 234:2, pages 1130-1146.
Crossref
Christina J. SigurdsonJason C. Bartz & Markus Glatzel. (2019) Cellular and Molecular Mechanisms of Prion Disease. Annual Review of Pathology: Mechanisms of Disease 14:1, pages 497-516.
Crossref
Amy Proal & Trevor Marshall. (2018) Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity. Frontiers in Pediatrics 6.
Crossref
Benjamin Mattes & Steffen Scholpp. (2018) Emerging role of contact-mediated cell communication in tissue development and diseases. Histochemistry and Cell Biology 150:5, pages 431-442.
Crossref
Arthur Charles-Orszag, Feng-Ching Tsai, Daria Bonazzi, Valeria Manriquez, Martin Sachse, Adeline Mallet, Audrey Salles, Keira Melican, Ralitza Staneva, Aurélie Bertin, Corinne Millien, Sylvie Goussard, Pierre Lafaye, Spencer Shorte, Matthieu Piel, Jacomine Krijnse-Locker, Françoise Brochard-Wyart, Patricia Bassereau & Guillaume Duménil. (2018) Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting. Nature Communications 9:1.
Crossref
Yukiko M. YamashitaMayu InabaMichael Buszczak. (2018) Specialized Intercellular Communications via Cytonemes and Nanotubes. Annual Review of Cell and Developmental Biology 34:1, pages 59-84.
Crossref
Albert A. Davis, Cheryl E.G. Leyns & David M. Holtzman. (2018) Intercellular Spread of Protein Aggregates in Neurodegenerative Disease. Annual Review of Cell and Developmental Biology 34:1, pages 545-568.
Crossref
Didier Vilette, Josquin Courte, Jean Michel Peyrin, Laurent Coudert, Laurent Schaeffer, Olivier Andréoletti & Pascal Leblanc. (2018) Cellular mechanisms responsible for cell-to-cell spreading of prions. Cellular and Molecular Life Sciences 75:14, pages 2557-2574.
Crossref
Mirosława Panasiuk, Michał Rychłowski, Natalia Derewońko & Krystyna Bieńkowska-Szewczyk. (2018) Tunneling Nanotubes as a Novel Route of Cell-to-Cell Spread of Herpesviruses. Journal of Virology 92:10.
Crossref
S. Bräuer, V. Zimyanin & A. Hermann. (2018) Prion-like properties of disease-relevant proteins in amyotrophic lateral sclerosis. Journal of Neural Transmission 125:4, pages 591-613.
Crossref
Neil A. Mabbott, James D. Alibhai & Jean Manson. 2018. Human Prion Diseases. Human Prion Diseases 85 107 .
Suzette A. Priola. 2018. Human Prion Diseases. Human Prion Diseases 45 68 .
Neil Mabbott. (2017) How do PrPSc Prions Spread between Host Species, and within Hosts?. Pathogens 6:4, pages 60.
Crossref
Gal HaimovichChristopher M. EckerMargaret C. DunaginElliott EgganArjun RajJeffrey E. GerstRobert H. Singer. (2017) Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells. Proceedings of the National Academy of Sciences 114:46.
Crossref
Soroor Farahnak, Toby K. McGovern, Rachael Kim, Michael O’Sullivan, Brian Chen, Minhyoung Lee, Haruka Yoshie, Anna Wang, Joyce Jang, Saba Al Heialy, Anne-Marie Lauzon & James G. Martin. (2017) Basic Fibroblast Growth Factor 2 Is a Determinant of CD4 T Cell–Airway Smooth Muscle Cell Communication through Membrane Conduits. The Journal of Immunology 199:9, pages 3086-3093.
Crossref
Bor Luen Tang. (2017) The use of mesenchymal stem cells (MSCs) for amyotrophic lateral sclerosis (ALS) therapy – a perspective on cell biological mechanisms. Reviews in the Neurosciences 28:7, pages 725-738.
Crossref
Guiliana Soraya Victoria & Chiara Zurzolo. (2017) The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases. Journal of Cell Biology 216:9, pages 2633-2644.
Crossref
Muhammad Nawaz & Farah Fatima. (2017) Extracellular Vesicles, Tunneling Nanotubes, and Cellular Interplay: Synergies and Missing Links. Frontiers in Molecular Biosciences 4.
Crossref
Barry M. Bradford, Boris Reizis & Neil A. Mabbott. (2017) Oral Prion Disease Pathogenesis Is Impeded in the Specific Absence of CXCR5-Expressing Dendritic Cells. Journal of Virology 91:10.
Crossref
Seng Zhu, Saïda Abounit, Carsten Korth & Chiara Zurzolo. (2017) Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine. Open Biology 7:3, pages 160328.
Crossref
Marie-Luce Vignais, Andr?s Caicedo, Jean-Marc Brondello & Christian Jorgensen. (2017) Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy. Stem Cells International 2017, pages 1-14.
Crossref
Daniela Sarnataro, Anna Pepe & Chiara Zurzolo. 2017. Prion Protein. Prion Protein 57 82 .
Neil A. Mabbott. 2017.
Marie-Luce Vignais, Jean Nakhle & Emmanuel Griessinger. 2017. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Elise Delage, Diégo Cordero Cervantes, Esthel Pénard, Christine Schmitt, Sylvie Syan, Andrea Disanza, Giorgio Scita & Chiara Zurzolo. (2016) Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes. Scientific Reports 6:1.
Crossref
Saïda Abounit, Luc Bousset, Frida Loria, Seng Zhu, Fabrice de Chaumont, Laura Pieri, Jean‐Christophe Olivo‐Marin, Ronald Melki & Chiara Zurzolo. (2016) Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes. The EMBO Journal 35:19, pages 2120-2138.
Crossref
Guiliana Soraya Victoria, Alexander Arkhipenko, Seng Zhu, Sylvie Syan & Chiara Zurzolo. (2016) Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact. Scientific Reports 6:1.
Crossref
Dominik Michael Frei, Erlend Hodneland, Ivan Rios-Mondragon, Anne Burtey, Beate Neumann, Jutta Bulkescher, Julia Schölermann, Rainer Pepperkok, Hans-Hermann Gerdes & Tanja Kögel. (2015) Novel microscopy-based screening method reveals regulators of contact-dependent intercellular transfer. Scientific Reports 5:1.
Crossref
Neil Andrew Mabbott & Barry Matthew Bradford. (2015) The Good, the Bad, and the Ugly of Dendritic Cells during Prion Disease. Journal of Immunology Research 2015, pages 1-13.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.