5,120
Views
66
CrossRef citations to date
0
Altmetric
Review

Mechanisms and functions of extracellular vesicle release in vivo—What we can learn from flies and worms

&
Pages 135-150 | Received 08 Aug 2016, Accepted 12 Sep 2016, Published online: 01 Nov 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Jonathon D. Walsh, Olivier Boivin & Maureen M. Barr. (2020) What about the males? the C. elegans sexually dimorphic nervous system and a CRISPR-based tool to study males in a hermaphroditic species. Journal of Neurogenetics 34:3-4, pages 323-334.
Read now
Ashley E. Russell, Alexandra Sneider, Kenneth W. Witwer, Paolo Bergese, Suvendra N. Bhattacharyya, Alexander Cocks, Emanuele Cocucci, Uta Erdbrügger, Juan M. Falcon-Perez, David W. Freeman, Thomas M. Gallagher, Shuaishuai Hu, Yiyao Huang, Steven M. Jay, Shin-ichi Kano, Gregory Lavieu, Aleksandra Leszczynska, Alicia M. Llorente, Quan Lu, Vasiliki Mahairaki, Dillon C. Muth, Nicole Noren Hooten, Matias Ostrowski, Ilaria Prada, Susmita Sahoo, Tine Hiorth Schøyen, Lifu Sheng, Deanna Tesch, Guillaume Van Niel, Roosmarijn E. Vandenbroucke, Frederik J. Verweij, Ana V. Villar, Marca Wauben, Ann M. Wehman, Hang Yin, David Raul Francisco Carter & Pieter Vader. (2019) Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop. Journal of Extracellular Vesicles 8:1.
Read now

Articles from other publishers (64)

Getulio Pereira de OliveiraJuniorJunior, Joshua A. Welsh, Brandy Pinckney, Cintia C. Palu, Shulin Lu, Alan Zimmerman, Raquel Hora Barbosa, Parul Sahu, Maeesha Noshin, Suryaram Gummuluru, John Tigges, Jennifer Clare Jones, Alexander R. Ivanov & Ionita C. Ghiran. (2023) Human red blood cells release microvesicles with distinct sizes and protein composition that alter neutrophil phagocytosis. Journal of Extracellular Biology 2:11.
Crossref
Michaela Liegertová & Olga Janoušková. (2023) Bridging the extracellular vesicle knowledge gap: insights from non-mammalian vertebrates, invertebrates, and early-diverging metazoans. Frontiers in Cell and Developmental Biology 11.
Crossref
Andarz Fazlollahpour Naghibi, Danyal Daneshdoust, Seyed Reza Taha, Sara Abedi, Pardis Abdali Dehdezi, Mahdieh Shariat Zadeh, Fatemeh Dokoohaki & Mehdi Soleymani-Goloujeh. (2023) Role of cancer stem cell-derived extracellular vesicles in cancer progression and metastasis. Pathology - Research and Practice 247, pages 154558.
Crossref
Gerrit Hugendieck, Marcus Lettau, Svenja Andreas, Sabrina Neumann, Natalie Reinhardt, Philipp Arnold, Franziska Theilig, Lorenz Bastian, Christoph Rogmans, Jörg P. Weimer, Inken Flörkemeier, Daniela Wesch, Norbert Arnold, Nicolai Maass, Ottmar Janssen, Dirk Bauerschlag & Nina Hedemann. (2023) Chemotherapy‐induced release of ADAM17 bearing EV as a potential resistance mechanism in ovarian cancer. Journal of Extracellular Vesicles 12:7.
Crossref
Claire Hill, Elizabeth R. Dellar & Luis Alberto Baena‐Lopez. (2022) Caspases help to spread the message via extracellular vesicles. The FEBS Journal 290:8, pages 1954-1972.
Crossref
Kai Wang & Cong Zeng. 2023. Extracellular Vesicles in Cardiovascular and Metabolic Diseases. Extracellular Vesicles in Cardiovascular and Metabolic Diseases 143 153 .
Adrià Razzauti, Teresa Lobo & Patrick Laurent. 2023. Cell-Secreted Vesicles. Cell-Secreted Vesicles 277 299 .
Ghader Babaei, Mehdi Asghari Vostakolaei, Masoumeh Rajabi Bazl, Shiva Gholizadeh-Ghaleh Aziz, Elham Gholipour & Kazem Nejati-Koshki. (2022) The role of exosomes in the molecular mechanisms of metastasis: Focusing on EMT and cancer stem cells. Life Sciences 310, pages 121103.
Crossref
Tiffaney Hsia, Anudeep Yekula, S. Maheen Batool, Yulia B. Rosenfeld, Dong Gil You, Ralph Weissleder, Hakho Lee, Bob S. Carter & Leonora Balaj. (2022) Glioblastoma‐derived extracellular vesicle subpopulations following 5‐aminolevulinic acid treatment bear diagnostic implications. Journal of Extracellular Vesicles 11:11.
Crossref
Laura E. Shippey, Susan G. Campbell, Andrew F. Hill & David P. Smith. (2022) Propagation of Parkinson's disease by extracellular vesicle production and secretion. Biochemical Society Transactions 50:5, pages 1303-1314.
Crossref
Rabab Hamzah, Karrer Alghazali, Alexandru Biris & Robert J. Griffin. (2022) Nanoparticle-Labeled Exosomes as Theranostic Agents: A Review. ACS Applied Nano Materials 5:9, pages 12265-12275.
Crossref
Doddy Denise Ojeda-Hernández, Mercedes A. Hernández-Sapiéns, Edwin E. Reza-Zaldívar, Alejandro Canales-Aguirre, Jordi A. Matías-Guiu, Jorge Matías-Guiu, Juan Carlos Mateos-Díaz, Ulises Gómez-Pinedo & Francisco Sancho-Bielsa. (2022) Exosomes and Biomaterials: In Search of a New Therapeutic Strategy for Multiple Sclerosis. Life 12:9, pages 1417.
Crossref
Abhimanyu Thakur, Xiaoshan Ke, Ya-Wen Chen, Pedram Motallebnejad, Kui Zhang, Qizhou Lian & Huanhuan Joyce Chen. (2022) The mini player with diverse functions: extracellular vesicles in cell biology, disease, and therapeutics. Protein & Cell 13:9, pages 631-654.
Crossref
Nada Basheir Ali, Ahmad Faizal Abdull Razis, Der Jiun Ooi, Kim Wei Chan, Norsharina Ismail & Jhi Biau Foo. (2022) Theragnostic Applications of Mammal and Plant-Derived Extracellular Vesicles: Latest Findings, Current Technologies, and Prospects. Molecules 27:12, pages 3941.
Crossref
Olga Janouskova, Regina Herma, Alena Semeradtova, David Poustka, Michaela Liegertova, Hana Auer Malinska & Jan Maly. (2022) Conventional and Nonconventional Sources of Exosomes–Isolation Methods and Influence on Their Downstream Biomedical Application. Frontiers in Molecular Biosciences 9.
Crossref
Oskar Staufer, Jochen Estebano Hernandez Bücher, Julius Fichtler, Martin Schröter, Ilia Platzman & Joachim P. Spatz. (2022) Vesicle Induced Receptor Sequestration: Mechanisms behind Extracellular Vesicle‐Based Protein Signaling. Advanced Science 9:13.
Crossref
Adrian Molière, Katharina B. Beer & Ann M. Wehman. (2022) Dopey proteins are essential but overlooked regulators of membrane trafficking. Journal of Cell Science 135:7.
Crossref
Sabrina Picciotto, Pamela Santonicola, Angela Paterna, Estella Rao, Samuele Raccosta, Daniele Paolo Romancino, Rosina Noto, Nicolas Touzet, Mauro Manno, Elia Di Schiavi, Antonella Bongiovanni & Giorgia Adamo. (2022) Extracellular Vesicles From Microalgae: Uptake Studies in Human Cells and Caenorhabditis elegans. Frontiers in Bioengineering and Biotechnology 10.
Crossref
Nancy Jo Pokrywka, Setse Bush & Sophie E. Nick. (2022) The R-SNARE Ykt6 is required for multiple events during oogenesis in Drosophila. Cells & Development 169, pages 203759.
Crossref
Anne Silvestre, Sharvani Shrinivas Shintre & Najma Rachidi. (2022) Released Parasite-Derived Kinases as Novel Targets for Antiparasitic Therapies. Frontiers in Cellular and Infection Microbiology 12.
Crossref
Flavia Lovisolo, Flavia Carton, Sarah Gino, Mario Migliario & Filippo Renò. (2021) Photobiomodulation induces microvesicle release in human keratinocytes: PI3 kinase-dependent pathway role. Lasers in Medical Science 37:1, pages 479-487.
Crossref
Gyöngyi Cinege, Lilla B. Magyar, Attila L. Kovács, Zita Lerner, Gábor Juhász, David Lukacsovich, Jochen Winterer, Tamás Lukacsovich, Zoltán Hegedűs, Éva Kurucz, Dan Hultmark, Csaba Földy & István Andó. (2022) Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids. Journal of Innate Immunity 14:4, pages 335-354.
Crossref
Abi G. Yates, Ryan C. Pink, Uta Erdbrügger, Pia R‐M. Siljander, Elizabeth R. Dellar, Paschalia Pantazi, Naveed Akbar, William R. Cooke, Manu Vatish, Emmanuel Dias‐Neto, Daniel C. Anthony & Yvonne Couch. (2022) In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo. Journal of Extracellular Vesicles 11:1.
Crossref
Abi G. Yates, Ryan C. Pink, Uta Erdbrügger, Pia R‐M. Siljander, Elizabeth R. Dellar, Paschalia Pantazi, Naveed Akbar, William R. Cooke, Manu Vatish, Emmanuel Dias‐Neto, Daniel C. Anthony & Yvonne Couch. (2022) In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo. Journal of Extracellular Vesicles 11:1.
Crossref
Simona Serratì, Antonio Palazzo, Annamaria Lapenna, Helena Mateos, Antonia Mallardi, René Massimiliano Marsano, Alessandra Quarta, Mario Del Rosso & Amalia Azzariti. (2021) Salting-Out Approach Is Worthy of Comparison with Ultracentrifugation for Extracellular Vesicle Isolation from Tumor and Healthy Models. Biomolecules 11:12, pages 1857.
Crossref
Anaïs Bécot, Maribel Lara Corona & Guillaume van Niel. (2021) L’imagerie in vivo . médecine/sciences 37:12, pages 1108-1115.
Crossref
Vincenzo Verdi, Anaïs Bécot, Guillaume Niel & Frederik J. Verweij. (2021) In vivo imaging of EVs in zebrafish: New perspectives from “the waterside”. FASEB BioAdvances 3:11, pages 918-929.
Crossref
Jeffrey D. Galley, Pamela Mar, Yijie Wang, Rachel Han, Adrian Rajab & Gail E. Besner. (2021) Urine-derived extracellular vesicle miRNAs as possible biomarkers for and mediators of necrotizing enterocolitis: A proof of concept study. Journal of Pediatric Surgery 56:11, pages 1966-1975.
Crossref
Diana Sousa, Raquel T. Lima, Vanessa Lopes-Rodrigues, Esperanza Gonzalez, Félix Royo, Cristina P. R. Xavier, Juan M. Falcón-Pérez & M. Helena Vasconcelos. (2021) Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles. Cells 10:11, pages 2886.
Crossref
Alexandre Androuin, Frederik J. Verweij & Guillaume van Niel. (2021) Zebrafish as a preclinical model for Extracellular Vesicle-based therapeutic development. Advanced Drug Delivery Reviews 176, pages 113815.
Crossref
Fumihiko Urabe, Kalyani Patil, Grant A. Ramm, Takahiro Ochiya & Carolina Soekmadji. (2021) Extracellular vesicles in the development of organ‐specific metastasis. Journal of Extracellular Vesicles 10:9.
Crossref
Riccardo Di Santo, Sabrina Romanò, Alberto Mazzini, Svetlana Jovanović, Giuseppina Nocca, Gaetano Campi, Massimiliano Papi, Marco De Spirito, Flavio Di Giacinto & Gabriele Ciasca. (2021) Recent Advances in the Label-Free Characterization of Exosomes for Cancer Liquid Biopsy: From Scattering and Spectroscopy to Nanoindentation and Nanodevices. Nanomaterials 11:6, pages 1476.
Crossref
Rabab N. Hamzah, Karrer M. Alghazali, Alexandru S. Biris & Robert J. Griffin. (2021) Exosome Traceability and Cell Source Dependence on Composition and Cell-Cell Cross Talk. International Journal of Molecular Sciences 22:10, pages 5346.
Crossref
Constança Oliveira, João Calmeiro, Mylène A. Carrascal, Amílcar Falcão, Célia Gomes, Bruno Miguel Neves & Maria Teresa Cruz. (2021) Exosomes as new therapeutic vectors for pancreatic cancer treatment. European Journal of Pharmaceutics and Biopharmaceutics 161, pages 4-14.
Crossref
Ioanna Maligianni, Christos Yapijakis, Flora Bacopoulou & George Chrousos. (2021) The Potential Role of Exosomes in Child and Adolescent Obesity. Children 8:3, pages 196.
Crossref
Xiao Xu, Limei Xu, Peng Zhang, Kan Ouyang, Yin Xiao, Jianyi Xiong, Daping Wang, Yujie Liang & Li Duan. (2020) Effects of ATP9A on Extracellular Vesicle Release and Exosomal Lipid Composition. Oxidative Medicine and Cellular Longevity 2020, pages 1-17.
Crossref
Chunyan Yang, Fangfang Chen, Ping Ren, Laren Lofchy, Chun Wan, Jingshi Shen, Guankui Wang, Hanmant Gaikwad, Jessica Ponder, Craig T. Jordan, Robert Scheinman & Dmitri Simberg. (2020) Delivery of a model lipophilic membrane cargo to bone marrow via cell-derived microparticles. Journal of Controlled Release 326, pages 324-334.
Crossref
Ebru Karasu, Julia Demmelmaier, Stephanie Kellermann, Karlheinz Holzmann, Jörg Köhl, Christoph Q. Schmidt, Miriam Kalbitz, Florian Gebhard, Markus S. Huber-Lang & Rebecca Halbgebauer. (2020) Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients. Frontiers in Immunology 11.
Crossref
Seyed MohammadReza Hashemian, Mohammad Hossein Pourhanifeh, Sara Fadaei, Ali Akbar Velayati, Hamed Mirzaei & Michael R. Hamblin. (2020) Non-coding RNAs and Exosomes: Their Role in the Pathogenesis of Sepsis. Molecular Therapy - Nucleic Acids 21, pages 51-74.
Crossref
Manon Auguste, Teresa Balbi, Caterina Ciacci & Laura Canesi. (2020) Conservation of Cell Communication Systems in Invertebrate Host–Defence Mechanisms: Possible Role in Immunity and Disease. Biology 9:8, pages 234.
Crossref
Eleanore V. O’Neil, Gregory W. Burns & Thomas E. Spencer. (2020) Extracellular vesicles: Novel regulators of conceptus-uterine interactions?. Theriogenology 150, pages 106-112.
Crossref
Thomas B. Duguet, Julien Soichot, Rostyslav Kuzyakiv, Lars Malmström & Lucienne Tritten. (2020) Extracellular Vesicle-Contained microRNA of C. elegans as a Tool to Decipher the Molecular Basis of Nematode Parasitism. Frontiers in Cellular and Infection Microbiology 10.
Crossref
Raghu Kalluri & Valerie S. LeBleu. (2020) The biology , function , and biomedical applications of exosomes . Science 367:6478.
Crossref
Parker H. Johnson, Neal J. Weinreb, James C. Cloyd, Paul J. Tuite & Reena V. Kartha. (2020) GBA1 mutations: Prospects for exosomal biomarkers in α-synuclein pathologies. Molecular Genetics and Metabolism 129:2, pages 35-46.
Crossref
Sabrina Picciotto, Daniele P. Romancino, Valentina Buffa, Antonella Cusimano, Antonella Bongiovanni & Giorgia Adamo. 2020. 83 111 .
Katharina B. Beer, Gholamreza Fazeli, Kristyna Judasova, Linda Irmisch, Jona Causemann, Jörg Mansfeld & Ann M. Wehman. (2019) Degron-tagged reporters probe membrane topology and enable the specific labelling of membrane-wrapped structures. Nature Communications 10:1.
Crossref
Katharina Kinslechner, Birgit Schütz, Martina Pistek, Philipp Rapolter, Hans Weitzenböck, Harald Hundsberger, Wolfgang Mikulits, Johannes Grillari, Clemens Röhrl, Markus Hengstschläger, Herbert Stangl & Mario Mikula. (2019) Loss of SR-BI Down-Regulates MITF and Suppresses Extracellular Vesicle Release in Human Melanoma. International Journal of Molecular Sciences 20:5, pages 1063.
Crossref
Claudia C. Tenen & Iva Greenwald. (2019) Cell Non-autonomous Function of daf-18/PTEN in the Somatic Gonad Coordinates Somatic Gonad and Germline Development in C. elegans Dauer Larvae. Current Biology 29:6, pages 1064-1072.e8.
Crossref
Vincent Hyenne, Shima Ghoroghi, Mayeul Collot, Joanna Bons, Gautier Follain, Sébastien Harlepp, Benjamin Mary, Jack Bauer, Luc Mercier, Ignacio Busnelli, Olivier Lefebvre, Nina Fekonja, Maria J. Garcia-Leon, Pedro Machado, François Delalande, Ana Amor López, Susana Garcia Silva, Frederik J. Verweij, Guillaume van Niel, Farida Djouad, Héctor Peinado, Christine Carapito, Andrey S. Klymchenko & Jacky G. Goetz. (2019) Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo. Developmental Cell 48:4, pages 554-572.e7.
Crossref
Fariba Rad, Mohammad Ghorbani, Amaneh Mohammadi Roushandeh & Mehryar Habibi Roudkenar. (2019) Mesenchymal stem cell-based therapy for autoimmune diseases: emerging roles of extracellular vesicles. Molecular Biology Reports 46:1, pages 1533-1549.
Crossref
Maibritt Mardahl, Anne Borup & Peter Nejsum. 2019. 39 112 .
Renee V. Goreham, Zeineb Ayed, Deanna Ayupova & Garima Dobhal. 2019. Comprehensive Nanoscience and Nanotechnology. Comprehensive Nanoscience and Nanotechnology 27 48 .
Jack Taylor & Mary Bebawy. (2019) Proteins Regulating Microvesicle Biogenesis and Multidrug Resistance in Cancer. PROTEOMICS 19:1-2.
Crossref
Ana-Citlali Gradilla, David Sanchez-Hernandez, Lucy Brunt & Steffen Scholpp. (2018) From top to bottom: Cell polarity in Hedgehog and Wnt trafficking. BMC Biology 16:1.
Crossref
Katja R. Kasimatis, Megan J. Moerdyk-Schauwecker, Nadine Timmermeyer & Patrick C. Phillips. (2018) Proteomic and evolutionary analyses of sperm activation identify uncharacterized genes in Caenorhabditis nematodes. BMC Genomics 19:1.
Crossref
Ruth E. Thomas, Evelyn S. Vincow, Gennifer E. Merrihew, Michael J. MacCoss, Marie Y. Davis & Leo J. Pallanck. (2018) Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles. PLOS Genetics 14:9, pages e1007694.
Crossref
Edwin E. Reza-Zaldivar, Mercedes A. Hernández-Sapiéns, Benito Minjarez, Yanet K. Gutiérrez-Mercado, Ana L. Márquez-Aguirre & Alejandro A. Canales-Aguirre. (2018) Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer’s Disease. Frontiers in Cellular Neuroscience 12.
Crossref
Ana-Citlali Gradilla, Eléanor Simon, Gustavo Aguilar & Isabel Guerrero. (2018) From intra- to extracellular vesicles: extracellular vesicles in developmental signalling. Essays in Biochemistry 62:2, pages 215-223.
Crossref
Juan WangMaureen M. Barr. (2018) Cell–cell communication via ciliary extracellular vesicles: clues from model systems. Essays in Biochemistry 62:2, pages 205-213.
Crossref
Maureen M Barr, L Rene García & Douglas S Portman. (2018) Sexual Dimorphism and Sex Differences in Caenorhabditis elegans Neuronal Development and Behavior . Genetics 208:3, pages 909-935.
Crossref
Zvonimir Marelja, Silke Leimkühler & Fanis Missirlis. (2018) Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism. Frontiers in Physiology 9.
Crossref
Katharina B. BeerJennifer Rivas-CastilloKenneth KuhnGholamreza FazeliBirgit KarmannJeremy F. NanceChristian Stigloher & Ann M. Wehman. (2018) Extracellular vesicle budding is inhibited by redundant regulators of TAT-5 flippase localization and phospholipid asymmetry. Proceedings of the National Academy of Sciences 115:6.
Crossref
Thomas Juan & Maximilian Fürthauer. (2018) Biogenesis and function of ESCRT-dependent extracellular vesicles. Seminars in Cell & Developmental Biology 74, pages 66-77.
Crossref
Charles E. Jackson, Benjamin S. Scruggs, Jean E. Schaffer & Phyllis I. Hanson. (2017) Effects of Inhibiting VPS4 Support a General Role for ESCRTs in Extracellular Vesicle Biogenesis. Biophysical Journal 113:6, pages 1342-1352.
Crossref