1,435
Views
72
CrossRef citations to date
0
Altmetric
Original

A Pilot Study Associating Urinary Concentrations of Phthalate Metabolites and Semen Quality

, , , , , , , & show all
Pages 143-154 | Received 11 Oct 2007, Accepted 12 Feb 2008, Published online: 09 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Vanessa R. Kay, Michael S. Bloom & Warren G. Foster. (2014) Reproductive and developmental effects of phthalate diesters in males. Critical Reviews in Toxicology 44:6, pages 467-498.
Read now
Michael Goodman, Judy S. LaKind & Donald R. Mattison. (2014) Do phthalates act as obesogens in humans? A systematic review of the epidemiological literature. Critical Reviews in Toxicology 44:2, pages 151-175.
Read now
Ester Anton & Stephen A. Krawetz. (2012) Spermatozoa as biomarkers for the assessment of human male infertility and genotoxicity. Systems Biology in Reproductive Medicine 58:1, pages 41-50.
Read now
Michael P. Diamond. (2010) Preface. Systems Biology in Reproductive Medicine 56:2, pages 111-112.
Read now

Articles from other publishers (68)

Pan Yang, Lang-Jing Deng, Jin-Ying Xie, Xiao-Jie Li, Xiao-Na Wang, Bin Sun, Tian-Qing Meng, Cheng-Liang Xiong, Yi-Chao Huang, Yi-Xin Wang, An Pan, Da Chen & Yan Yang. (2023) Phthalate exposure with sperm quality among healthy Chinese male adults: The role of sperm cellular function. Environmental Pollution 331, pages 121755.
Crossref
Dhammika N. Magana‐Arachchi & Rasika P. Wanigatunge. 2023. Microplastics in the Ecosphere. Microplastics in the Ecosphere 97 112 .
Soleiman Ramezanifar, Sona Beyrami, Younes Mehrifar, Ehsan Ramezanifar, Zahra Soltanpour, Mahshid Namdari & Noradin Gharari. (2023) Occupational Exposure to Physical and Chemical Risk Factors: A Systematic Review of Reproductive Pathophysiological Effects in Women and Men. Safety and Health at Work 14:1, pages 17-30.
Crossref
Shirsha Mondal & Arindam Bandyopadhyay. (2023) From oxidative imbalance to compromised standard sperm parameters: Toxicological aspect of phthalate esters on spermatozoa. Environmental Toxicology and Pharmacology 98, pages 104085.
Crossref
Houpeng Wang, Huan He, Yu Wei, Xin Gao, Taifa Zhang & Jinxia Zhai. (2022) Do phthalates and their metabolites cause poor semen quality? A systematic review and meta-analysis of epidemiological studies on risk of decline in sperm quality. Environmental Science and Pollution Research 30:12, pages 34214-34228.
Crossref
Alessandra Gallo. (2022) Reprotoxic Impact of Environment, Diet, and Behavior. International Journal of Environmental Research and Public Health 19:3, pages 1303.
Crossref
Inês Mesquita, Margarida Lorigo & Elisa Cairrao. (2021) Update about the disrupting‐effects of phthalates on the human reproductive system. Molecular Reproduction and Development 88:10, pages 650-672.
Crossref
Mark P. Green, Alexandra J. Harvey, Bethany J. Finger & Gerard A. Tarulli. (2021) Endocrine disrupting chemicals: Impacts on human fertility and fecundity during the peri-conception period. Environmental Research 194, pages 110694.
Crossref
Thoin F. Begum, Victor Y. Fujimoto, Roy Gerona, Alexandra McGough, Nikolaus Lenhart, Rebecca Wong, Evelyn Mok-Lin, Jonathan Melamed, Celeste D. Butts & Michael S. Bloom. (2021) A pilot investigation of couple-level phthalates exposure and in vitro fertilization (IVF) outcomes. Reproductive Toxicology 99, pages 56-64.
Crossref
Nele Van De Winkel, Yagmur Yurtkap, Vicky Dhooghe, Shengyun Huang, Govindan Malarvannan, Guy Van den Mooter, Adrian Covaci, Ann Van Schepdael & Marc Miserez. (2020) Phthalates and infertility: an issue in hernia meshes?. European Surgery 52:5, pages 210-216.
Crossref
Shaoyu Tang, Chang He, Phong K. Thai, Amy Heffernan, Soumini Vijayasarathy, Leisa Toms, Kristie Thompson, Peter Hobson, Benjamin J. Tscharke, Jake W. O’Brien, Kevin V. Thomas & Jochen F. Mueller. (2020) Urinary Concentrations of Bisphenols in the Australian Population and Their Association with the Per Capita Mass Loads in Wastewater. Environmental Science & Technology 54:16, pages 10141-10148.
Crossref
Alessandra Gallo, Raffaele Boni & Elisabetta Tosti. (2020) Gamete quality in a multistressor environment. Environment International 138, pages 105627.
Crossref
Yulan Zhang, Shichang Kang, Steve Allen, Deonie Allen, Tanguang Gao & Mika Sillanpää. (2020) Atmospheric microplastics: A review on current status and perspectives. Earth-Science Reviews 203, pages 103118.
Crossref
Lidia Caporossi, Alessandra Alteri, Giovanni Campo, Enrico Paci, Giovanna Tranfo, Silvia Capanna, Enrico Papaleo, Daniela Pigini, Paola Viganò & Bruno Papaleo. (2020) Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center. International Journal of Environmental Research and Public Health 17:2, pages 489.
Crossref
Irfan Ashraf Badroo, Ashiq Hussain Khanday, Zainab Kalimuddin Ali & Suriya Ashraf Badroo. 2020. Handbook of Research on Environmental and Human Health Impacts of Plastic Pollution. Handbook of Research on Environmental and Human Health Impacts of Plastic Pollution 288 313 .
Xiaofei Song, Qiongfang Zhuo, Shaoyu Tang, Tianfa Xie, Zhiyuan Chen, Zhijun Zang, Yanan Zhang, Xiaojun Niu, Hua Yin, Feng Zeng & Chang He. (2020) Concentrations of phthalates metabolites in blood and semen and the potential effects on semen concentration and motility among residents of the Pearl River Delta region in China. Emerging Contaminants 6, pages 39-43.
Crossref
Kristian Leisegang & Ralf Henkel. 2020. Male Infertility. Male Infertility 437 453 .
Qingyu Huang, Liangpo Liu, Yan Wu, Xiaofei Wang, Lianzhong Luo, Bingru Nan, Jie Zhang, Meiping Tian & Heqing Shen. (2019) Seminal plasma metabolites mediate the associations of multiple environmental pollutants with semen quality in Chinese men. Environment International 132, pages 105066.
Crossref
Molly Estill, Russ Hauser, Feiby L. Nassan, Alan Moss & Stephen A. Krawetz. (2019) The effects of di-butyl phthalate exposure from medications on human sperm RNA among men. Scientific Reports 9:1.
Crossref
Kirsten A. Baken, Nathalie Lambrechts, Sylvie Remy, Vicente Mustieles, Andrea Rodríguez-Carrillo, Christiana M. Neophytou, Nicolas Olea & Greet Schoeters. (2019) A strategy to validate a selection of human effect biomarkers using adverse outcome pathways: Proof of concept for phthalates and reproductive effects. Environmental Research 175, pages 235-256.
Crossref
Yu Wang, Hongkai Zhu & Kurunthachalam Kannan. (2019) A Review of Biomonitoring of Phthalate Exposures. Toxics 7:2, pages 21.
Crossref
Meiping Tian, Liangpo Liu, Jie Zhang, Qingyu Huang & Heqing Shen. (2019) Positive association of low-level environmental phthalate exposure with sperm motility was mediated by DNA methylation: A pilot study. Chemosphere 220, pages 459-467.
Crossref
Lu Lu, Honghui Rong, Chong Wu, Bo Cui, Yujing Huang, Yao Tan, Ling Zhang, Yi Peng, Jose M. Garcia & Ji-an Chen. (2019) Levels of phthalate acid esters and sex hormones and their possible sources in traffic-patrol policemen in Chongqing. Environmental Science and Pollution Research 26:9, pages 9005-9013.
Crossref
Elizabeth G. Radke, Joseph M. Braun, John D. Meeker & Glinda S. Cooper. (2018) Phthalate exposure and male reproductive outcomes: A systematic review of the human epidemiological evidence. Environment International 121, pages 764-793.
Crossref
Stefania Lymperi & Aleksander Giwercman. (2018) Endocrine disruptors and testicular function. Metabolism 86, pages 79-90.
Crossref
Océane Albert, Jonathan Y. Huang, Katarina Aleksa, Barbara F. Hales, Cynthia G. Goodyer, Bernard Robaire, Jonathan Chevrier & Peter Chan. (2018) Exposure to polybrominated diphenyl ethers and phthalates in healthy men living in the greater Montreal area: A study of hormonal balance and semen quality. Environment International 116, pages 165-175.
Crossref
A Broe, A Pottegård, J Hallas, T P Ahern, J Fedder & P Damkier. (2018) Association between use of phthalate-containing medication and semen quality among men in couples referred for assisted reproduction. Human Reproduction 33:3, pages 503-511.
Crossref
Birgit Bjerre Høyer, Virissa Lenters, Aleksander Giwercman, Bo A.G. Jönsson, Gunnar Toft, Karin S. Hougaard, Jens Peter E. Bonde & Ina Olmer Specht. (2018) Impact of Di-2-Ethylhexyl Phthalate Metabolites on Male Reproductive Function: a Systematic Review of Human Evidence. Current Environmental Health Reports 5:1, pages 20-33.
Crossref
Liangpo Liu, Heng Wang, Meiping Tian, Jie Zhang, Parinya Panuwet, Priya Esilda D'Souza, Dana Boyd Barr, Qingyu Huang, Yankai Xia & Heqing Shen. (2017) Phthalate metabolites related to infertile biomarkers and infertility in Chinese men. Environmental Pollution 231, pages 291-300.
Crossref
Haotian Wu, Molly S Estill, Alexander Shershebnev, Alexander Suvorov, Stephen A Krawetz, Brian W Whitcomb, Holly Dinnie, Tayyab Rahil, Cynthia K Sites & J Richard Pilsner. (2017) Preconception urinary phthalate concentrations and sperm DNA methylation profiles among men undergoing IVF treatment: a cross-sectional study. Human Reproduction 32:11, pages 2159-2169.
Crossref
Pallav Sengupta, Sulagna Dutta & Elzbieta Krajewska-Kulak. (2016) The Disappearing Sperms: Analysis of Reports Published Between 1980 and 2015. American Journal of Men's Health 11:4, pages 1279-1304.
Crossref
Qing Chen, Huan Yang, Niya Zhou, Lei Sun, Huaqiong Bao, Lu Tan, Hongqiang Chen, Xi Ling, Guowei Zhang, Linping Huang, Lianbing Li, Mingfu Ma, Hao Yang, Xiaogang Wang, Peng Zou, Kaige Peng, Taixiu Liu, Xiefei Shi, Dejian Feng, Ziyuan Zhou, Lin Ao, Zhihong Cui & Jia Cao. (2017) Phthalate exposure, even below US EPA reference doses, was associated with semen quality and reproductive hormones: Prospective MARHCS study in general population. Environment International 104, pages 58-68.
Crossref
Xinwen Dong, Yunbo Zhang, Jin Dong, Yue Zhao, Jipeng Guo, Zhanju Wang, Mingqi Liu, Xiaolin Na & Cheng Wang. (2017) Urinary metabolomic profiling in rats exposed to dietary di(2-ethylhexyl) phthalate (DEHP) using ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS). Environmental Science and Pollution Research 24:20, pages 16659-16672.
Crossref
Feiby L. Nassan, Brent A. Coull, Niels E. Skakkebaek, Michelle A. Williams, Ramace Dadd, Lidia Mínguez-Alarcón, Stephen A. Krawetz, Elizabeth J. Hait, Joshua R. Korzenik, Alan C. Moss, Jennifer B. Ford & Russ Hauser. (2016) A crossover–crossback prospective study of dibutyl-phthalate exposure from mesalamine medications and semen quality in men with inflammatory bowel disease. Environment International 95, pages 120-130.
Crossref
Gerard M.H. Swaen, Miriam J.E. Urlings & Maurice P. Zeegers. (2016) Outcome reporting bias in observational epidemiology studies on phthalates. Annals of Epidemiology 26:8, pages 597-599.e4.
Crossref
S. W. Thurston, J. Mendiola, A. R. Bellamy, H. Levine, C. Wang, A. Sparks, J. B. Redmon, E. Z. Drobnis & S. H. Swan. (2016) Phthalate exposure and semen quality in fertile US men. Andrology 4:4, pages 632-638.
Crossref
Chao Wang, Lu Yang, Shu Wang, Zhan Zhang, Yongquan Yu, Meilin Wang, Meghan Cromie, Weimin Gao & Shou-Lin Wang. (2016) The classic EDCs, phthalate esters and organochlorines, in relation to abnormal sperm quality: a systematic review with meta-analysis. Scientific Reports 6:1.
Crossref
Ran Wang, Xiaohong Xu, Huifang Weng, Shengyao Yan & Yangyang Sun. (2016) Effects of early pubertal exposure to di-(2-ethylhexyl) phthalate on social behavior of mice. Hormones and Behavior 80, pages 117-124.
Crossref
Chuan Liu, Peng Qian, Lingling Yang, Lei Zhang, Chunhai Chen, Mindi He, Yonghui Lu, Wei Feng, Min Li, Yanwen Zhang, Min Zhong, Zhengping Yu & Zhou Zhou. (2015) Pubertal exposure to di-(2-ethylhexyl)-phthalate inhibits G9a-mediated histone methylation during spermatogenesis in mice. Archives of Toxicology 90:4, pages 955-969.
Crossref
M.S. Bloom, B.W. Whitcomb, Z. Chen, A. Ye, K. Kannan & G.M. Buck Louis. (2015) Associations between urinary phthalate concentrations and semen quality parameters in a general population. Human Reproduction 30:11, pages 2645-2657.
Crossref
Hongquan Cai, Weiwei Zheng, Pai Zheng, Shu Wang, Hui Tan, Gengsheng He & Weidong Qu. (2015) Human urinary/seminal phthalates or their metabolite levels and semen quality: A meta-analysis. Environmental Research 142, pages 486-494.
Crossref
Changjiang Liu, Letian Zhao, Li Wei & Lianbing Li. (2015) DEHP reduces thyroid hormones via interacting with hormone synthesis-related proteins, deiodinases, transthyretin, receptors, and hepatic enzymes in rats. Environmental Science and Pollution Research 22:16, pages 12711-12719.
Crossref
Judy S. LaKind, Jon R. Sobus, Michael Goodman, Dana Boyd Barr, Peter Fürst, Richard J. Albertini, Tye E. Arbuckle, Greet Schoeters, Yu-Mei Tan, Justin Teeguarden, Rogelio Tornero-Velez & Clifford P. Weisel. (2014) A proposal for assessing study quality: Biomonitoring, Environmental Epidemiology, and Short-lived Chemicals (BEES-C) instrument. Environment International 73, pages 195-207.
Crossref
Atsuko Araki, Takahiko Mitsui, Chihiro Miyashita, Tamie Nakajima, Hisao Naito, Sachiko Ito, Seiko Sasaki, Kazutoshi Cho, Tamiko Ikeno, Katsuya Nonomura & Reiko Kishi. (2014) Association between Maternal Exposure to di(2-ethylhexyl) Phthalate and Reproductive Hormone Levels in Fetal Blood: The Hokkaido Study on Environment and Children's Health. PLoS ONE 9:10, pages e109039.
Crossref
J. Ernst, J.-C. Jann, R. Biemann, H. M. Koch & B. Fischer. (2014) Effects of the environmental contaminants DEHP and TCDD on estradiol synthesis and aryl hydrocarbon receptor and peroxisome proliferator-activated receptor signalling in the human granulosa cell line KGN. Molecular Human Reproduction 20:9, pages 919-928.
Crossref
Li-Ping Huang, Ching-Chang Lee, Jer-Pei Fan, Po-Hsiu Kuo, Tung-Sheng Shih & Ping-Chi Hsu. (2013) Urinary metabolites of di(2-ethylhexyl) phthalate relation to sperm motility, reactive oxygen species generation, and apoptosis in polyvinyl chloride workers. International Archives of Occupational and Environmental Health 87:6, pages 635-646.
Crossref
Hai-Xia Sui, Lei Zhang, Ping-Gu Wu, Yan Song, Ling Yong, Da-Jin Yang, Ding-Guo Jiang & Zhao-Ping Liu. (2014) Concentration of di(2-ethylhexyl) phthalate (DEHP) in foods and its dietary exposure in China. International Journal of Hygiene and Environmental Health 217:6, pages 695-701.
Crossref
Hueiwang Anna Jeng. (2014) Exposure to Endocrine Disrupting Chemicals and Male Reproductive Health. Frontiers in Public Health 2.
Crossref
Océane Albert & Bernard Jégou. (2014) A critical assessment of the endocrine susceptibility of the human testis to phthalates from fetal life to adulthood. Human Reproduction Update 20:2, pages 231-249.
Crossref
Xue Han, Zhihong Cui, Niya Zhou, Mingfu Ma, Lianbing Li, Yafei Li, Hui Lin, Lin Ao, Weiqun Shu, Jinyi Liu & Jia Cao. (2014) Urinary phthalate metabolites and male reproductive function parameters in Chongqing general population, China. International Journal of Hygiene and Environmental Health 217:2-3, pages 271-278.
Crossref
Lidia Mínguez-Alarcón, Jaime Mendiola & Alberto M. Torres-Cantero. 2014. Male Infertility. Male Infertility 181 192 .
Sellappan Selvaraju, Meritxell Jodar & Stephen A. Krawetz. 2017. Developmental and Reproductive Toxicology. Developmental and Reproductive Toxicology 185 203 .
Joanna Jurewicz, Michał Radwan, Wojciech Sobala, Danuta Ligocka, Paweł Radwan, Michał Bochenek, Wanda Hawuła, Lucjusz Jakubowski & Wojciech Hanke. (2013) Human urinary phthalate metabolites level and main semen parameters, sperm chromatin structure, sperm aneuploidy and reproductive hormones. Reproductive Toxicology 42, pages 232-241.
Crossref
Yao Yu, Sally W. Thurston, Russ Hauser & Hua Liang. (2013) Model averaging procedure for partially linear single-index models. Journal of Statistical Planning and Inference 143:12, pages 2160-2170.
Crossref
Lars Rylander & Anna Rignell-Hydbom. 2013. Effects of Persistent and Bioactive Organic Pollutants on Human Health. Effects of Persistent and Bioactive Organic Pollutants on Human Health 315 331 .
Jure Knez. (2013) Endocrine-disrupting chemicals and male reproductive health. Reproductive BioMedicine Online 26:5, pages 440-448.
Crossref
Jason R. Kovac, Alexander W. Pastuszak & Dolores J. Lamb. (2013) The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility. Fertility and Sterility 99:4, pages 998-1007.
Crossref
Stephan P. Krotz, Sandra A. Carson, Cynthia Tomey & John E. Buster. (2012) Phthalates and bisphenol do not accumulate in human follicular fluid. Journal of Assisted Reproduction and Genetics 29:8, pages 773-777.
Crossref
Liangpo Liu, Huaqiong Bao, Feng Liu, Jie Zhang & Heqing Shen. (2012) Phthalates exposure of Chinese reproductive age couples and its effect on male semen quality, a primary study. Environment International 42, pages 78-83.
Crossref
Loa Nordkap, Ulla Nordström Joensen, Martin Blomberg Jensen & Niels Jørgensen. (2012) Regional differences and temporal trends in male reproductive health disorders: Semen quality may be a sensitive marker of environmental exposures. Molecular and Cellular Endocrinology 355:2, pages 221-230.
Crossref
John D. Meeker & Kelly K. Ferguson. 2012. Dioxins and Health. Dioxins and Health 415 443 .
Tzung-Hai Yen, Dan-Tzu Lin-Tan & Ja-Liang Lin. (2011) Food safety involving ingestion of foods and beverages prepared with phthalate-plasticizer-containing clouding agents. Journal of the Formosan Medical Association 110:11, pages 671-684.
Crossref
N. PantAB PantM. Shukla, N. MathurYK Gupta & DK Saxena. (2010) Environmental and experimental exposure of phthalate esters: The toxicological consequence on human sperm. Human & Experimental Toxicology 30:6, pages 507-514.
Crossref
Joanna Jurewicz & Wojciech Hanke. (2011) Exposure to phthalates: Reproductive outcome and children health. A review of epidemiological studies. International Journal of Occupational Medicine and Environmental Health 24:2.
Crossref
Andrea Borchers, Suzanne S. Teuber, Carl L. Keen & M. Eric Gershwin. (2009) Food Safety. Clinical Reviews in Allergy & Immunology 39:2, pages 95-141.
Crossref
C. Matthew Peterson, Douglas T. Carrell, Michael Varner, Joseph Stanford, Mary Croughan & Germaine Buck Louis. 2010. Reproductive Endocrinology and Infertility. Reproductive Endocrinology and Infertility 781 803 .
Caroline Herr, Anja zur Nieden, Holger M. Koch, Hans-Christian Schuppe, Christian Fieber, Jürgen Angerer, Thomas Eikmann & Nikolaos I. Stilianakis. (2009) Urinary di(2-ethylhexyl)phthalate (DEHP)—Metabolites and male human markers of reproductive function. International Journal of Hygiene and Environmental Health 212:6, pages 648-653.
Crossref
Joanna Jurewicz, Wojciech Hanke, Michał Radwan & Jens Bonde. (2009) Environmental factors and semen quality. International Journal of Occupational Medicine and Environmental Health 22:4.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.