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Characterizing monoclonal antibody structure by carboxyl group footprinting

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Patanachai Limpikirati, John E. Hale, Mark Hazelbaker, Yongbo Huang, Zhiguang Jia, Mahdieh Yazdani, Eric M. Graban, Robert C. Vaughan & Richard W. Vachet. (2019) Covalent labeling and mass spectrometry reveal subtle higher order structural changes for antibody therapeutics. mAbs 11:3, pages 463-476.
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Lucy Yan Pan, Oscar Salas-Solano & John F. Valliere-Douglass. (2017) Localized conformational interrogation of antibody and antibody-drug conjugates by site-specific carboxyl group footprinting. mAbs 9:2, pages 307-318.
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Christine P. Chan. (2016) Forced degradation studies: current trends and future perspectives for protein-based therapeutics. Expert Review of Proteomics 13:7, pages 651-658.
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Articles from other publishers (31)

Jason M. Hogan, Peter S. Lee, Susan C. Wong, Sean M. West, Winse H. Morishige, Christine Bee, Gamze Camdere Tapia, Arvind Rajpal, Pavel Strop & Gavin Dollinger. (2023) Residue-Level Characterization of Antibody Binding Epitopes Using Carbene Chemical Footprinting. Analytical Chemistry 95:8, pages 3922-3931.
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Nicholas B. Borotto & Talitha Kamakamakamae Richards. (2022) Rapid Online Oxidation of Proteins and Peptides via Electrospray-Accelerated Ozonation. Journal of the American Society for Mass Spectrometry 33:11, pages 2078-2086.
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Catherine Y. Tremblay, Zachary J. Kirsch & Richard W. Vachet. (2022) Complementary Structural Information for Antibody–Antigen Complexes from Hydrogen–Deuterium Exchange and Covalent Labeling Mass Spectrometry. Journal of the American Society for Mass Spectrometry 33:7, pages 1303-1314.
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Yanchun Lin & Michael L. Gross. (2022) Mass Spectrometry-Based Structural Proteomics for Metal Ion/Protein Binding Studies. Biomolecules 12:1, pages 135.
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Lukáš Fojtík, Jan Fiala, Petr Pompach, Josef Chmelík, Václav Matoušek, Petr Beier, Zdeněk Kukačka & Petr Novák. (2021) Fast Fluoroalkylation of Proteins Uncovers the Structure and Dynamics of Biological Macromolecules. Journal of the American Chemical Society 143:49, pages 20670-20679.
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Nidhi Verma, Budhi Sagar Tiwari & Alok Pandya. (2021) Field Deployable Vertical Flow Based Immunodevice for Detection of Potato Virus Y in Potato Leaves. ACS Agricultural Science & Technology 1:5, pages 558-565.
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Jonathan M. Goodwin, Ward G. WalkupIVIV, Kirsty Hooper, Taoyingnan Li, Chieko Kishi-ItakuraAylwin NgTimothy Lehmberg, Archana JhaSravya KommineniKatherine FletcherJorge Garcia-FortanetYaya FanQing TangMenghao WeiAsmita AgrawalSagar R. BudheSreekanth R. RouduriDan Baird, Jeff Saunders, Janna Kiselar, Mark R. Chance, Andrea Ballabio, Brent A. AppletonJohn H. Brumell, Oliver Florey & Leon O. Murphy. (2021) GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis. Science Advances 7:40.
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Noé Escareño, Natalia Hassan, Marcelo J. Kogan, Josué Juárez, Antonio Topete & Adrián Daneri-Navarro. (2021) Microfluidics-assisted conjugation of chitosan-coated polymeric nanoparticles with antibodies: Significance in drug release, uptake, and cytotoxicity in breast cancer cells. Journal of Colloid and Interface Science 591, pages 440-450.
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Catherine Y. Tremblay, Patanachai Limpikirati & Richard W. Vachet. (2021) Complementary Structural Information for Stressed Antibodies from Hydrogen–Deuterium Exchange and Covalent Labeling Mass Spectrometry. Journal of the American Society for Mass Spectrometry 32:5, pages 1237-1248.
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M. Rachel Mehaffey, Jiwon Lee, Jiwon Jung, Michael B. Lanzillotti, Edwin E. Escobar, Keith R. Morgenstern, George Georgiou & Jennifer S. Brodbelt. (2020) Mapping a Conformational Epitope of Hemagglutinin A Using Native Mass Spectrometry and Ultraviolet Photodissociation. Analytical Chemistry 92:17, pages 11869-11878.
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Patanachai K. Limpikirati, Bo Zhao, Xiao Pan, Stephen J. Eyles & Richard W. Vachet. (2020) Covalent Labeling/Mass Spectrometry of Monoclonal Antibodies with Diethylpyrocarbonate: Reaction Kinetics for Ensuring Protein Structural Integrity. Journal of the American Society for Mass Spectrometry 31:6, pages 1223-1232.
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Xiaoran Roger Liu, Mengru Mira Zhang & Michael L. Gross. (2020) Mass Spectrometry-Based Protein Footprinting for Higher-Order Structure Analysis: Fundamentals and Applications. Chemical Reviews 120:10, pages 4355-4454.
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Xiao Pan, Patanachai Limpikirati, Huan Chen, Tianying Liu & Richard W. Vachet. (2020) Higher-Order Structure Influences the Kinetics of Diethylpyrocarbonate Covalent Labeling of Proteins. Journal of the American Society for Mass Spectrometry 31:3, pages 658-665.
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Sayan Gupta, Yan Chen, Christopher J. Petzold, Daniel P. DePonte & Corie Y. Ralston. (2019) Development of Container Free Sample Exposure for Synchrotron X-ray Footprinting. Analytical Chemistry 92:1, pages 1565-1573.
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Liuqing Shi & Michael L. Gross. (2019) Fast Photochemical Oxidation of Proteins Coupled with Mass Spectrometry. Protein & Peptide Letters 26:1, pages 27-34.
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Chunyang Guo, Ming Cheng & Michael L. Gross. (2018) Protein-Metal-Ion Interactions Studied by Mass Spectrometry-Based Footprinting with Isotope-Encoded Benzhydrazide. Analytical Chemistry 91:2, pages 1416-1423.
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Viktor Háda, Attila Bagdi, Zsolt Bihari, Sarolta Baginé Timári, Ádám Fizil & Csaba SzántayJr.Jr.. (2018) Recent advancements, challenges, and practical considerations in the mass spectrometry-based analytics of protein biotherapeutics: A viewpoint from the biosimilar industry. Journal of Pharmaceutical and Biomedical Analysis 161, pages 214-238.
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Pei Liu, Miyoshi Haruta, Benjamin B. Minkoff & Michael R. Sussman. (2018) Probing a Plant Plasma Membrane Receptor Kinase’s Three-Dimensional Structure Using Mass Spectrometry-Based Protein Footprinting. Biochemistry 57:34, pages 5159-5168.
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Janna KiselarMark R. Chance. (2018) High-Resolution Hydroxyl Radical Protein Footprinting: Biophysics Tool for Drug Discovery. Annual Review of Biophysics 47:1, pages 315-333.
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Margaret Lin, Denise Krawitz, Matthew D. Callahan, Galahad Deperalta & Aaron T. Wecksler. (2018) Characterization of ELISA Antibody-Antigen Interaction using Footprinting-Mass Spectrometry and Negative Staining Transmission Electron Microscopy. Journal of The American Society for Mass Spectrometry 29:5, pages 961-971.
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Aaron T. Wecksler, Jian Yin, Paula Lee Tao, Bruce Kabakoff, Alavattam Sreedhara & Galahad Deperalta. (2018) Photodisruption of the Structurally Conserved Cys-Cys-Trp Triads Leads to Reduction-Resistant Scrambled Intrachain Disulfides in an IgG1 Monoclonal Antibody. Molecular Pharmaceutics 15:4, pages 1598-1606.
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Tianying Liu, Tyler M. Marcinko, Patrick A. Kiefer & Richard W. Vachet. (2017) Using Covalent Labeling and Mass Spectrometry To Study Protein Binding Sites of Amyloid Inhibiting Molecules. Analytical Chemistry 89:21, pages 11583-11591.
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Benjamin B. Minkoff, Joshua M. Blatz, Faraz A. Choudhury, Daniel Benjamin, J. Leon Shohet & Michael R. Sussman. (2017) Plasma-Generated OH Radical Production for Analyzing Three-Dimensional Structure in Protein Therapeutics. Scientific Reports 7:1.
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Ke Sherry Li, Guodong Chen, Jingjie Mo, Richard Y.-C. Huang, Ekaterina G. Deyanova, Brett R. Beno, Steve R. O’Neil, Adrienne A. Tymiak & Michael L. Gross. (2017) Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics. Analytical Chemistry 89:14, pages 7742-7749.
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Liwen Wang & Mark R. Chance. (2017) Protein Footprinting Comes of Age: Mass Spectrometry for Biophysical Structure Assessment. Molecular & Cellular Proteomics 16:5, pages 706-716.
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Vladimir Sarpe, Atefeh Rafiei, Morgan Hepburn, Nicholas Ostan, Anthony B. Schryvers & David C. Schriemer. (2016) High Sensitivity Crosslink Detection Coupled With Integrative Structure Modeling in the Mass Spec Studio. Molecular & Cellular Proteomics 15:9, pages 3071-3080.
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Ying Zhang, Weidong Cui, Aaron T. Wecksler, Hao Zhang, Patricia Molina, Galahad Deperalta & Michael L. Gross. (2016) Native MS and ECD Characterization of a Fab–Antigen Complex May Facilitate Crystallization for X-ray Diffraction. Journal of the American Society for Mass Spectrometry 27:7, pages 1139-1142.
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James A. Madsen, Yan Yin, Jing Qiao, Vanessa Gill, Kutralanathan Renganathan, Wing-Yee Fu, Stephen Smith & James Anderson. (2016) Covalent Labeling Denaturation Mass Spectrometry for Sensitive Localized Higher Order Structure Comparisons. Analytical Chemistry 88:4, pages 2478-2488.
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Szabolcs Fekete, Davy Guillarme, Pat Sandra & Koen Sandra. (2015) Chromatographic, Electrophoretic, and Mass Spectrometric Methods for the Analytical Characterization of Protein Biopharmaceuticals. Analytical Chemistry 88:1, pages 480-507.
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Hao Zhang, Haijun Liu, Robert E. Blankenship & Michael L. Gross. (2015) Isotope-Encoded Carboxyl Group Footprinting for Mass Spectrometry-Based Protein Conformational Studies. Journal of the American Society for Mass Spectrometry 27:1, pages 178-181.
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Nicholas B. Borotto, Yuping Zhou, Stephen R. Hollingsworth, John E. Hale, Eric M. Graban, Robert C. Vaughan & Richard W. Vachet. (2015) Investigating Therapeutic Protein Structure with Diethylpyrocarbonate Labeling and Mass Spectrometry. Analytical Chemistry 87:20, pages 10627-10634.
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