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mAbs Volume 9, 2017 - Issue 3
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bisFabs: Tools for rapidly screening hybridoma IgGs for their activities as bispecific antibodies

Sanket PatkeDepartment of Protein Chemistry, Genentech, South San Francisco, CA, USA
,
Ji LiDepartment of Translational Oncology, Genentech, South San Francisco, CA, USA
,
Peiyin WangDepartment of Translational Oncology, Genentech, South San Francisco, CA, USA
,
Dion SlagaDepartment of Translational Oncology, Genentech, South San Francisco, CA, USA
,
Jennifer JohnstonDepartment of Translational Oncology, Genentech, South San Francisco, CA, USA
,
Sunil BhaktaDepartment of Translational Oncology, Genentech, South San Francisco, CA, USA
,
Siler PanowskiDepartment of Translational Oncology, Genentech, South San Francisco, CA, USA
,
Liping L. SunDepartment of Translational Oncology, Genentech, South San Francisco, CA, USA
,
Teemu JunttilaDepartment of Translational Oncology, Genentech, South San Francisco, CA, USA
,
Justin M. ScheerDepartment of Protein Chemistry, Genentech, South San Francisco, CA, USA
&
Diego A. EllermanDepartment of Protein Chemistry, Genentech, South San Francisco, CA, USACorrespondence[email protected]
 show all
Pages 430-437 | Received 16 Sep 2016, Accepted 07 Jan 2017, Published online: 16 Mar 2017

Citations (11)

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Pallavi Bhatta, Kevin D. Whale, Amy K. Sawtell, Clare L. Thompson, Stephen E. Rapecki, David A. Cook, Breda M. Twomey, Milena Mennecozzi, Laura E. Starkie, Emily M. C. Barry, Shirley J. Peters, Ahmad M. Kamal & Helene M. Finney. (2021) Bispecific antibody target pair discovery by high-throughput phenotypic screening using in vitro combinatorial Fab libraries. mAbs 13:1.
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Articles from other publishers (10)

Xiaohan Guo, Yi Wu, Ying Xue, Na Xie & Guobo Shen. (2023) Revolutionizing cancer immunotherapy: unleashing the potential of bispecific antibodies for targeted treatment. Frontiers in Immunology 14.
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Fabien Thoreau & Vijay Chudasama. (2022) Enabling the next steps in cancer immunotherapy: from antibody-based bispecifics to multispecifics, with an evolving role for bioconjugation chemistry. RSC Chemical Biology 3:2, pages 140-169.
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Nazzareno Dimasi, Amit Kumar & Changshou Gao. (2021) Generation of bispecific antibodies using chemical conjugation methods. Drug Discovery Today: Technologies 40, pages 13-24.
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Peter Szijj & Vijay Chudasama. (2021) The renaissance of chemically generated bispecific antibodies. Nature Reviews Chemistry 5:2, pages 78-92.
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Antoine Maruani, Peter A. Szijj, Calise Bahou, João C. F. Nogueira, Stephen Caddick, James R. Baker & Vijay Chudasama. (2020) A Plug-and-Play Approach for the De Novo Generation of Dually Functionalized Bispecifics . Bioconjugate Chemistry 31:3, pages 520-529.
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Mathias Kahl, Florian Settele, Paul Knick, Ulrich Haupts & Eva Bosse-Doenecke. (2018) Mabfilin and Fabfilin - New antibody-scaffold fusion formats for multispecific targeting concepts. Protein Expression and Purification 149, pages 51-65.
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Petra Verdino, Shane Atwell & Stephen J Demarest. (2018) Emerging trends in bispecific antibody and scaffold protein therapeutics. Current Opinion in Chemical Engineering 19, pages 107-123.
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Zehua Sun, Lixin Yan, Jiansong Tang, Qian Qian, Jerica Lenberg, Dandan Zhu, Wan Liu, Kao Wu, Yilin Wang & Shiqiang Lu. (2018) Brief introduction of current technologies in isolation of broadly neutralizing HIV-1 antibodies. Virus Research 243, pages 75-82.
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James T. Patterson, Jason Isaacson, Lisa Kerwin, Ghazi Atassi, Rohit Duggal, Damien Bresson, Tong Zhu, Heyue Zhou, Yanwen Fu & Gunnar F. Kaufmann. (2017) PSMA-targeted bispecific Fab conjugates that engage T cells. Bioorganic & Medicinal Chemistry Letters 27:24, pages 5490-5495.
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James T. Patterson, Edwige Gros, Heyue Zhou, Ghazi Atassi, Lisa Kerwin, Lisa Carmody, Tong Zhu, Bryan Jones, Yanwen Fu & Gunnar F. Kaufmann. (2017) Chemically generated IgG2 bispecific antibodies through disulfide bridging. Bioorganic & Medicinal Chemistry Letters 27:16, pages 3647-3652.
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